SOX13 Gene

HGNC Family	SRY (sex determining region Y)-boxes (SOX)
Name	SRY (sex determining region Y)-box 13
Description	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence across multiple studies indicates that SOX13 functions as a potent oncogene in several solid and hematological malignancies. In colorectal cancer, SOX13 overexpression drives metastasis by transactivating key effectors such as SNAI2 and c‑MET, while also modulating tumor stemness and chemoresistance via a circRNA/miR‑133b axis. In gastric cancer, SOX13 is synchronously up‑regulated with PAX8, thereby promoting proliferation through the regulation of cell cycle effectors including Aurora B and Cyclin B1. Similarly, in hepatocellular carcinoma SOX13 enhances cell invasion and epithelial‑to‑mesenchymal transition through the transcriptional activation of Twist1 (in conjunction with SOX5), and in breast cancer its up‑regulation accelerates cell viability and glycolysis by modulating the Wnt/β‑catenin pathway via a TRIM11‑dependent mechanism. Moreover, in an acute myeloid leukemia model, IL‑34–induced up‑regulation of SOX13 contributes to increased leukemic stem cell properties and aggressive tumor infiltration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn developmental and non‑tumorigenic contexts, SOX13 also plays important regulatory roles. It modulates the Wnt/TCF pathway during early embryogenesis by interacting with Hhex—a homeodomain factor crucial for liver development—thus fine‑tuning key signaling events. In contrast to its up‑regulation in many cancers, reduced SOX13 expression in peripheral blood mononuclear cells has been observed in patients with Klinefelter syndrome, a finding that may be linked to the characteristic germ cell loss and associated autoimmunity in these individuals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies underscore the multifunctional character of SOX13 as a context‑dependent regulator—promoting cancer progression through enhanced cell proliferation, metastasis, and chemoresistance in various tumor types, while also contributing to the modulation of critical developmental pathways. The diverse roles of SOX13 not only highlight its potential as a prognostic biomarker across a spectrum of human diseases but also as a promising target for therapeutic intervention.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng Du, Xiaowei Li, Weibo Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX13 promotes colorectal cancer metastasis by transactivating SNAI2 and c-MET."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-1233-4"}], "href": "https://doi.org/10.1038/s41388-020-1233-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32111984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32111984"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lv Lv, Lu Yi, Bojie Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0071589 aggravates stemness and oxaliplatin resistance in colorectal cancer through sponging miR-133b to upregulate SOX13 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-023-04819-8"}], "href": "https://doi.org/10.1007/s11010-023-04819-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37522976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37522976"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Liang-Yu Bie, Dan Li, Yan Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX13 dependent PAX8 expression promotes the proliferation of gastric carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1646751"}], "href": "https://doi.org/10.1080/21691401.2019.1646751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31353958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31353958"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Min Feng, Fei Fang, Ting Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41374-020-0445-0"}], "href": "https://doi.org/10.1038/s41374-020-0445-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32461589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32461589"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoyan Jin, Xuan Shao, Wenyang Pang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2073127"}], "href": "https://doi.org/10.1080/21655979.2022.2073127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35611828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35611828"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dongyue Zhang, Xiaoxi Cui, Yifei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-05822-z"}], "href": "https://doi.org/10.1038/s41419-023-05822-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37149693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37149693"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vanessa Marfil, Marta Moya, Christophe E Pierreux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between Hhex and SOX13 modulates Wnt/TCF activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.046649"}], "href": "https://doi.org/10.1074/jbc.M109.046649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20028982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20028982"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rossella Cannarella, Michele Salemi, Rosita A Condorelli, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SOX13"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene downregulation in peripheral blood mononuclear cells of patients with Klinefelter syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian J Androl (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/aja.aja_37_20"}], "href": "https://doi.org/10.4103/aja.aja_37_20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33109779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33109779"}]}]}]}
Synonyms	SOX-13, ICA12
Proteins	SOX13_HUMAN
NCBI Gene ID	9580
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SOX13 has 5,591 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 111 datasets.

Click the + buttons to view associations for SOX13 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SOX13 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SOX13 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SOX13 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SOX13 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SOX13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SOX13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SOX13 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SOX13 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SOX13 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SOX13 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SOX13 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SOX13 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SOX13 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SOX13 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SOX13 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SOX13 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SOX13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SOX13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SOX13 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SOX13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SOX13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SOX13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SOX13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SOX13 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SOX13 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SOX13 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SOX13 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SOX13 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SOX13 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SOX13 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SOX13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SOX13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SOX13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SOX13 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SOX13 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SOX13 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SOX13 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SOX13 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SOX13 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SOX13 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SOX13 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.