{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMultiple studies have identified SOX30 as a tumor‐suppressive transcription factor that exerts its effects through distinct mechanistic pathways. In lung cancer, SOX30 is commonly silenced by hypermethylation, and its re‐expression induces cancer cell apoptosis and inhibits proliferation via direct activation of the p53 promoter, establishing its role as a key tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Consistently, clinical analyses have shown that higher SOX30 levels correlate with more favorable overall survival, particularly in lung adenocarcinoma patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work in lung cancer metastasis has revealed that SOX30 expression is markedly reduced in metastatic tumors. Functionally, SOX30 suppresses tumor cell migration and invasion by attenuating Wnt/β-catenin signaling—not only by directly repressing β-catenin transcription but also by engaging in protein–protein interactions that compete with TCF binding."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In hepatocellular carcinoma, overexpression of miR-645 leads to post-transcriptional repression of SOX30, resulting in diminished p53 activation and enhanced tumor growth, thereby underscoring the critical antitumorigenic impact of SOX30."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence further suggests that the tumor-suppressive roles of SOX30 extend to other malignancies. Its involvement is currently being explored in prostate cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and similar investigations in bladder cancer, malignant lymphomas, and breast cancer point toward a potential inhibitory effect on tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " In acute myeloid leukemia, SOX30 is downregulated through hypermethylation, and its overexpression substantially reduces cell proliferation and colony formation via inhibition of the Wnt/β-catenin pathway, thereby decreasing leukemic growth in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "F Han, W Liu, X Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.370"}], "href": "https://doi.org/10.1038/onc.2014.370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25435374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25435374"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fei Han, Wenbin Liu, Hualiang Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep13630"}], "href": "https://doi.org/10.1038/srep13630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26330328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26330328"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fei Han, Wen-Bin Liu, Xiao-Yan Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2018.04.026"}], "href": "https://doi.org/10.1016/j.ebiom.2018.04.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29739711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29739711"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jie Tao, Zhikui Liu, Yufeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2018.10.032"}], "href": "https://doi.org/10.1016/j.ijbiomac.2018.10.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30312695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30312695"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qiang Fu, Zhenye Sun, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX30, a target gene of miR-653-5p, represses the proliferation and invasion of prostate cancer cells through inhibition of Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-019-0195-4"}], "href": "https://doi.org/10.1186/s11658-019-0195-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31889959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31889959"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yang Liu, Han Wang, Jianhua Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of SRY-box containing gene 30 is related to malignant phenotypes of human bladder cancer and correlates with poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-018-4560-x"}], "href": "https://doi.org/10.1186/s12885-018-4560-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29880037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29880037"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chengzhi Zhan, Tao Wang, Hua You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Different expressions of miR-125b and SOX30 in malignant lymphomas and their significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30358229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30358229"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hui Peng, Yang Luo, Jing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation of sex-determining region Y-box 30 with tumor characteristics and its prognostic value in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23232"}], "href": "https://doi.org/10.1002/jcla.23232"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32157740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32157740"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ye Liu, Wei Wang, Yuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX30 confers a tumor suppressive effect in acute myeloid leukemia through inactivation of Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2020.101578"}], "href": "https://doi.org/10.1016/j.mcp.2020.101578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32334007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32334007"}]}]}]}