{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSOX7 is a transcription factor of the SOX family with pivotal roles in embryonic development and cell fate decision. Early studies demonstrated its widespread expression during development and its capacity to repress Wnt/β‐catenin signaling by reducing β‐catenin–mediated transcription, a function that is critical for proper differentiation. Notably, constitutive expression of SOX7 in human embryonic stem cells drives the formation of stable endoderm progenitors with a bias toward the extraembryonic endoderm lineage, underscoring its role in early lineage specification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, SOX7 acts predominantly as a tumor suppressor. It can physically interact with β‐catenin, thereby dampening oncogenic Wnt signaling—a pathway frequently implicated in the initiation and progression of tumors such as prostate and colorectal cancers. Loss or epigenetic silencing of SOX7 (for example, via promoter hypermethylation) has been observed in several human cancers, leading to unchecked expression of cell cycle regulators like c‐Myc and Cyclin D1. Moreover, in lung cancers, while its exact role remains to be fully elucidated, microRNAs such as miR‐24-3p and miR‐9 have been shown to target and downregulate SOX7, thereby promoting cellular proliferation, invasion, and adhesion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its cell‐autonomous tumor suppressor functions, SOX7 also exerts influence on the tumor microenvironment. In pericytes, activation of SOX7 by PDGF‐BB leads to upregulation of IL-33, a cytokine that contributes to metastasis by recruiting tumor-associated macrophages. Additionally, in tumor-associated endothelial cells, modulation of SOX7 expression by SHP2 signaling affects angiogenesis, with re-expression of SOX7 capable of restoring endothelial function and impacting vascular abnormalities. Together, these findings reveal SOX7 as a multifaceted regulator that not only guides developmental processes but also imposes a critical checkpoint against tumor progression and modulates key components of the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "W Takash, J Cañizares, N Bonneaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/29.21.4274"}], "href": "https://doi.org/10.1093/nar/29.21.4274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11691915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11691915"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cheryle A Séguin, Jonathan S Draper, Andras Nagy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2008.06.018"}], "href": "https://doi.org/10.1016/j.stem.2008.06.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18682240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18682240"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lizheng Guo, Diansheng Zhong, Stephen Lau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-07-2175"}], "href": "https://doi.org/10.1158/1541-7786.MCR-07-2175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18819930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18819930"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takahide Hayano, Manoj Garg, Dong Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX7 is down-regulated in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-9966-32-17"}], "href": "https://doi.org/10.1186/1756-9966-32-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23557216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23557216"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daniel B Stovall, Meimei Wan, Lance D Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The regulation of SOX7 and its tumor suppressive role in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2013.07.025"}], "href": "https://doi.org/10.1016/j.ajpath.2013.07.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24012678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24012678"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Geng-Gang Wu, Wen-Hong Li, Wen-Guang He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0088796"}], "href": "https://doi.org/10.1371/journal.pone.0088796"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24558429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24558429"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lichun Han, Wei Wang, Wei Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-9 is involved in TGF-β1-induced lung cancer cell invasion and adhesion by targeting SOX7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13120"}], "href": "https://doi.org/10.1111/jcmm.13120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28266181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28266181"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Liang Yan, Jinzhu Ma, Yiping Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-24-3p promotes cell migration and proliferation in lung cancer by targeting SOX7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26553"}], "href": "https://doi.org/10.1002/jcb.26553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29231262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29231262"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yunlong Yang, Patrik Andersson, Kayoko Hosaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11385"}], "href": "https://doi.org/10.1038/ncomms11385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27150562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27150562"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhiyong Xu, Chunyi Guo, Qiaoli Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-26697-8"}], "href": "https://doi.org/10.1038/s41467-021-26697-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34728626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34728626"}]}]}]}