{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA survey of these studies reveals a broad and intricate landscape of phosphatidylinositol 3‐kinase (PI3K)–centered signaling cascades regulating autophagy, cell survival, metabolism, differentiation, and stress responses across multiple cell types and disease models—including tumor progression, neuronal function, immune responses, and developmental processes. Notably, however, none of the provided abstracts directly mention or characterize the role of SPACA7. In this context, while extensive research has delineated key regulatory proteins and mechanisms—for example, the modulation of PI3K activity by newly identified binding partners, the differential regulation of autophagy through distinct PI3K complexes, and the integration of growth factor and stress signals into cellular fate decisions"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "22"}]}, {"type": "t", "text": "—there is currently no evidence within this body of work to place SPACA7 within these networks."}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGiven the detailed mechanistic insights provided by these investigations into PI3K-dependent pathways and their roles in balancing cell survival, apoptosis, and differentiation, further studies are warranted to explore whether SPACA7 might interface with any aspect of these signaling cascades. Such future work could determine if SPACA7 plays a modulatory or scaffolding role in processes like autophagosome biogenesis, metabolic regulation, or stress-related signaling, thereby unveiling a potential novel function for SPACA7 in cellular homeostasis. This gap in the literature underscores the need for targeted research to establish the physiological and pathological significance of SPACA7."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "29"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yun Zhong, Qing Jun Wang, Xianting Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1854"}], "href": "https://doi.org/10.1038/ncb1854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19270693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19270693"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer W Hill, Kevin W Williams, Chianping Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI32964"}], "href": "https://doi.org/10.1172/JCI32964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18382766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18382766"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cheryl A Doughty, Blair F Bleiman, Dean J Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-12-4788"}], "href": "https://doi.org/10.1182/blood-2005-12-4788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16449529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16449529"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Susanne Kleber, Ignacio Sancho-Martinez, Benedict Wiestler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yes and PI3K bind CD95 to signal invasion of glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2008.02.003"}], "href": "https://doi.org/10.1016/j.ccr.2008.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18328427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18328427"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michelle H W Laird, Sang Hoon Rhee, Darren J Perkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLR4/MyD88/PI3K interactions regulate TLR4 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.1208763"}], "href": "https://doi.org/10.1189/jlb.1208763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19289601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19289601"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sandrine Sander, Dinis P Calado, Lakshmi Srinivasan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2012.06.012"}], "href": "https://doi.org/10.1016/j.ccr.2012.06.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22897848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22897848"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Si Qing Zhang, William G Tsiaras, Toshiyuki Araki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.12.4062-4072.2002"}], "href": "https://doi.org/10.1128/MCB.22.12.4062-4072.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12024020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12024020"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "You-Tong Wu, Hui-Ling Tan, Qing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.9099"}], "href": "https://doi.org/10.4161/auto.9099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19556857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19556857"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Enzo Calautti, Jian Li, Stefania Saoncella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M506119200"}], "href": "https://doi.org/10.1074/jbc.M506119200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16036919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16036919"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Barbara Geering, Pedro R Cutillas, Gemma Nock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0700373104"}], "href": "https://doi.org/10.1073/pnas.0700373104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17470792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17470792"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yves Jossin, André M Goffinet "}, {"type": "b", "children": [{"type": "t", "text": "Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00928-07"}], "href": "https://doi.org/10.1128/MCB.00928-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17698586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17698586"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hans H Bock, Yves Jossin, Pingsheng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M306416200"}], "href": "https://doi.org/10.1074/jbc.M306416200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12882964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12882964"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ji Luo, Julie R McMullen, Cassandra L Sobkiw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.21.9491-9502.2005"}], "href": "https://doi.org/10.1128/MCB.25.21.9491-9502.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16227599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16227599"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hiromichi Ebi, Carlotta Costa, Anthony C Faber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1314124110"}], "href": "https://doi.org/10.1073/pnas.1314124110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24327733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24327733"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jonathon N Winnay, Jeremie Boucher, Marcelo A Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2121"}], "href": "https://doi.org/10.1038/nm.2121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20348923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20348923"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hung-Yun Lin, I-Chen Yu, Ruey-Shen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.22252"}], "href": "https://doi.org/10.1002/hep.22252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18449947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18449947"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xuxiao Zhang, Oscar Vadas, Olga Perisic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.01.026"}], "href": "https://doi.org/10.1016/j.molcel.2011.01.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21362552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21362552"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Thati Madhusudhan, Hongjie Wang, Wei Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7496"}], "href": "https://doi.org/10.1038/ncomms7496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25754093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25754093"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hee Jun Cho, Kyoung Eun Baek, Shizuya Saika, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.12.035"}], "href": "https://doi.org/10.1016/j.bbrc.2006.12.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17187756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17187756"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ty Dale Troutman, Wei Hu, Stephanie Fulenchek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1118579109"}], "href": "https://doi.org/10.1073/pnas.1118579109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22187460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22187460"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Michael G Kharas, Matthew R Janes, Vanessa M Scarfone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI33337"}], "href": "https://doi.org/10.1172/JCI33337"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18704194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18704194"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Shunming Zhu, Fei Sun, Weijie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-011-0799-0"}], "href": "https://doi.org/10.1007/s11010-011-0799-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21461612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21461612"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Kathrine Abell, Antonio Bilancio, Richard W E Clarkson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1242"}], "href": "https://doi.org/10.1038/ncb1242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15793565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15793565"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jung Sun Heo, Ho Jae Han "}, {"type": "b", "children": [{"type": "t", "text": "ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1634/stemcells.2005-0588"}], "href": "https://doi.org/10.1634/stemcells.2005-0588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16916926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16916926"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Kazuma Kaneko, Kohjiro Ueki, Noriko Takahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2010.11.005"}], "href": "https://doi.org/10.1016/j.cmet.2010.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21109194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21109194"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Tzu-Rong Su, Jen-Jie Lin, Chi-Chu Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of melanogenesis by gallic acid: possible involvement of the PI3K/Akt, MEK/ERK and Wnt/β-catenin signaling pathways in B16F10 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms141020443"}], "href": "https://doi.org/10.3390/ijms141020443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24129178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24129178"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Barbara Wegiel, Catherine J Baty, David Gallo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.027433"}], "href": "https://doi.org/10.1074/jbc.M109.027433"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19509285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19509285"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "M Dean Chamberlain, Tangyne R Berry, M Chris Pastor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M409769200"}], "href": "https://doi.org/10.1074/jbc.M409769200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15377662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15377662"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Kanae Hyoda, Toru Hosoi, Naohiro Horie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.12.007"}], "href": "https://doi.org/10.1016/j.bbrc.2005.12.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16375864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16375864"}]}]}]}