{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collected studies predominantly describe the diverse functions of the zinc finger transcription factor MAZR (also known as PATZ1) – a member of the POZ/BTB family – in regulating gene expression programs during lymphocyte development. In these works, MAZR/PATZ1 is shown to contribute to the epigenetic programming of T‐cell lineage differentiation by modulating coreceptor expression (e.g. CD8 and ThPOK) in thymocytes, and by interacting with other transcriptional regulators during the maturation of conventional and innate-like T cells. Notably, none of the provided abstracts report any findings regarding the function of SPATA31A3."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations elaborate on the roles of MAZR/PATZ1 beyond lymphocyte specification. In endothelial cells and other tissues, PATZ1 is implicated in the regulation of cell senescence, the DNA damage response via modulation of p53‐dependent transcription, and control of angiogenic processes – functions that bear relevance for vascular aging, diabetic complications, and tumor suppression. Again, there is no mention of any functional involvement of SPATA31A3 within these contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have provided structural insights into PATZ1, revealing details of its BTB domain that govern homodimerization and co‐repressor interactions, as well as identifying a regulatory role in adipocyte differentiation through interactions with other transcriptional modulators. Collectively, these findings underscore the multifaceted regulatory functions of MAZR/PATZ1 in development, cell homeostasis, and metabolism – yet none address or attribute any role to SPATA31A3."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ivan Bilic, Christina Koesters, Bernd Unger, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1860"}], "href": "https://doi.org/10.1038/ni.1860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20383150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20383150"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shinya Sakaguchi, Daniela Hainberger, Caroline Tizian, et al. 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