{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA thorough review of the provided abstracts reveals that none of them mention or characterize the protein SPATA31C1. In other words, there is no direct experimental or observational evidence within these studies describing any function, localization, or biological role for SPATA31C1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInstead, the compiled literature predominantly addresses the functions of S100 family proteins—especially S100A8 and S100A9 (also known as calprotectin, MRP8/MRP14)—in regulating inflammatory responses across a wide range of pathological contexts. These studies detail how these proteins serve as endogenous ligands for receptors such as Toll‑like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE), thereby modulating key signaling cascades including NF‑κB and MAP kinase pathways. They are implicated in processes such as phagocyte activation, modulation of cytokine and chemokine production, immune cell recruitment, and even the orchestration of tumor progression and metastasis"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": ", and others).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these abstracts offer significant insights into complex inflammatory networks mediated by S100A8/A9 and associated receptors, they do not provide any information regarding SPATA31C1. As such, the functional role of SPATA31C1 remains unaddressed in this collection, underscoring a gap in the literature. Future studies will be necessary to determine whether SPATA31C1 might participate in similar signaling pathways or regulatory networks as those elaborated here."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Thomas Vogl, Klaus Tenbrock, Stephan Ludwig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1638"}], "href": "https://doi.org/10.1038/nm1638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17767165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17767165"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sachie Hiratsuka, Akira Watanabe, Hiroyuki Aburatani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1507"}], "href": "https://doi.org/10.1038/ncb1507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17128264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17128264"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pingyan Cheng, Cesar A Corzo, Noreen Luetteke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20080132"}], "href": "https://doi.org/10.1084/jem.20080132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18809714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18809714"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Brian D Corbin, Erin H Seeley, Andrea Raab, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metal chelation and inhibition of bacterial growth in tissue abscesses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1152449"}], "href": "https://doi.org/10.1126/science.1152449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18276893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18276893"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Pratima Sinha, Chinonyerem Okoro, Dirk Foell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.7.4666"}], "href": "https://doi.org/10.4049/jimmunol.181.7.4666"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18802069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18802069"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mie Ichikawa, Roy Williams, Ling Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A8/A9 activate key genes and pathways in colon tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-10-0394"}], "href": "https://doi.org/10.1158/1541-7786.MCR-10-0394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21228116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21228116"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Thomas Vogl, Stephan Ludwig, Matthias Goebeler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-02-0446"}], "href": "https://doi.org/10.1182/blood-2004-02-0446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15331440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15331440"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Olga Turovskaya, Dirk Foell, Pratima Sinha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgn188"}], "href": "https://doi.org/10.1093/carcin/bgn188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18689872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18689872"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "John H Boyd, Bernard Kan, Haley Roberts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.167544"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.167544"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18403730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18403730"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kevin Croce, Huiyun Gao, Yunmei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid-related protein-8/14 is critical for the biological response to vascular injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.108.814582"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.108.814582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19620505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19620505"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Karen Vandal, Pascal Rouleau, Annie Boivin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.171.5.2602"}], "href": "https://doi.org/10.4049/jimmunol.171.5.2602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12928412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12928412"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rebekka K Schneider, Monica Schenone, Monica Ventura Ferreira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4047"}], "href": "https://doi.org/10.1038/nm.4047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26878232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26878232"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Josie A R Hobbs, Richard May, Kiki Tanousis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid cell function in MRP-14 (S100A9) null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.7.2564-2576.2003"}], "href": "https://doi.org/10.1128/MCB.23.7.2564-2576.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12640137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12640137"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Peter L E M van Lent, Arjen B Blom, Rik F P Schelbergen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.34315"}], "href": "https://doi.org/10.1002/art.34315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22143922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22143922"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Carle Ryckman, Shaun R McColl, Karen Vandal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.11079"}], "href": "https://doi.org/10.1002/art.11079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12905486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12905486"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Michael J Kraakman, Man Ks Lee, Annas Al-Sharea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI92450"}], "href": "https://doi.org/10.1172/JCI92450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28504650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28504650"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Thomas Vogl, Athanasios Stratis, Viktor Wixler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI89867"}], "href": "https://doi.org/10.1172/JCI89867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29611822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29611822"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Su-Yu Tsai, Jesus A Segovia, Te-Hung Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003848"}], "href": "https://doi.org/10.1371/journal.ppat.1003848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24391503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24391503"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kendra J Greenlee, David B Corry, David A Engler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.10.7312"}], "href": "https://doi.org/10.4049/jimmunol.177.10.7312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17082650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17082650"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yina Wu, Yulin Li, Congcong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.113.02843"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.113.02843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24711518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24711518"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Matteo Riva, Eva Källberg, Per Björk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2567.2012.03619.x"}], "href": "https://doi.org/10.1111/j.1365-2567.2012.03619.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22804476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22804476"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Marie-Astrid Raquil, Nadia Anceriz, Pascal Rouleau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blockade of antimicrobial proteins S100A8 and S100A9 inhibits phagocyte migration to the alveoli in streptococcal pneumonia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.5.3366"}], "href": "https://doi.org/10.4049/jimmunol.180.5.3366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18292562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18292562"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ninecia R Scott, Rosemary V Swanson, Noor Al-Hammadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI130546"}], "href": "https://doi.org/10.1172/JCI130546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32134742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32134742"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Chris A Mares, Sandra S Ojeda, Elizabeth G Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.00215-08"}], "href": "https://doi.org/10.1128/IAI.00215-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18411294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18411294"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Min Jeoung Lee, Jin-Ku Lee, Ji Won Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0038801"}], "href": "https://doi.org/10.1371/journal.pone.0038801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22962574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22962574"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Tae-Young Ha, Keun-A Chang, Jeong a Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0008840"}], "href": "https://doi.org/10.1371/journal.pone.0008840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20098622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20098622"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Vijay Chaitanya Ganta, Min Choi, Charles R Farber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antiangiogenic VEGF"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "165"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.118.034165"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.118.034165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30586702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30586702"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Hala Zreiqat, Daniele Belluoccio, Margaret M Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A8 and S100A9 in experimental osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar2917"}], "href": "https://doi.org/10.1186/ar2917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20105291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20105291"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Maike Willers, Thomas Ulas, Lena Völlger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2020.08.019"}], "href": "https://doi.org/10.1053/j.gastro.2020.08.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32805279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32805279"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Daren Low, Renuka Subramaniam, Li Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5440"}], "href": "https://doi.org/10.18632/oncotarget.5440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26431492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26431492"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Pinyang Cheng, Erika A Eksioglu, Xianghong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A9-induced overexpression of PD-1/PD-L1 contributes to ineffective hematopoiesis in myelodysplastic syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-019-0397-9"}], "href": "https://doi.org/10.1038/s41375-019-0397-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737486"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Irene Müller, Thomas Vogl, Kathleen Pappritz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Heart Fail (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCHEARTFAILURE.117.004125"}], "href": "https://doi.org/10.1161/CIRCHEARTFAILURE.117.004125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29158436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29158436"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xuan Wei, Bing Wu, Jing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.114.013789"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.114.013789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25820336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25820336"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "R F P Schelbergen, W de Munter, M H J van den Bosch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2014-205480"}], "href": "https://doi.org/10.1136/annrheumdis-2014-205480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25180294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25180294"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Isatou Bah, Ajinkya Kumbhare, Lam Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellimm.2018.07.003"}], "href": "https://doi.org/10.1016/j.cellimm.2018.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30025864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30025864"}]}]}]}