SPDYE2B Gene

HGNC Family Speedy/RINGO cell cycle regulator family (SPDY)
Name speedy/RINGO cell cycle regulator family member E2B
Description Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Mar 2025]
Summary
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Deficiency of SPDYE2B results in ER stress, caspase‐12–mediated apoptosis, and defects in sperm chromatin condensation and nuclear integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its reproductive functions, SPDYE2B also influences cellular differentiation and stress responses in non‐gonadal tissues. In adipocytes, related isoforms of this transcription factor act as gatekeepers during adipogenesis by inhibiting the expression and stabilization of key adipogenic regulators such as PPARγ and C/EBPα. Knockdown of these factors facilitates adipocyte maturation, which in turn is associated with improved glucose tolerance and insulin sensitivity—a feature that suggests a potential role as a therapeutic target in obesity and metabolic syndrome. In cardiomyocytes, cardiac ischemia/reperfusion injury triggers SPDYE2B expression, cleavage, and nuclear accumulation; here, SPDYE2B directly stimulates the hexosamine biosynthetic pathway to enhance O‐GlcNAc protein modifications that mitigate oxidative stress and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the kidney, SPDYE2B has been implicated in modulating the cellular response to ischemia/reperfusion injury. Elevated SPDYE2B levels in renal tubular cells correlate with enhanced expression of pro‐apoptotic factors (e.g., CHOP, Bax, and cleaved caspase‐3) and are associated with increased inflammation, neutrophil and macrophage infiltration, and fibrotic remodeling. In contrast, SPDYE2B deficiency confers protection by reducing tubular apoptosis and inflammatory signaling while promoting cellular proliferation and repair, thereby attenuating renal dysfunction and tubulointerstitial fibrosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ippei Nagamori, Norikazu Yabuta, Takayuki Fujii, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M602051200"}], "href": "https://doi.org/10.1074/jbc.M602051200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16595651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16595651"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mohamed El-Alfy, Lamia Azzi, Julie Lessard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stage-specific expression of the Atce1/Tisp40alpha isoform of CREB3L4 in mouse spermatids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Androl (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2164/jandrol.106.000596"}], "href": "https://doi.org/10.2164/jandrol.106.000596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16728718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16728718"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stelzer Gil, Dicken Yosef, Niv Golan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The enigma of ATCE1, an acrosome-associated transcription factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2006.06.029"}], "href": "https://doi.org/10.1016/j.ydbio.2006.06.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16925989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16925989"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ippei Nagamori, Kentaro Yomogida, Masahito Ikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2006.01013.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2006.01013.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16999736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16999736"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "T-H Kim, S-H Jo, H Choi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Tisp40 prevents cardiac ischemia/reperfusion injury through the hexosamine biosynthetic pathway in male mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-023-39159-0"}], "href": "https://doi.org/10.1038/s41467-023-39159-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37291168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37291168"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Cheng-Cheng Xiao, Jie Zhang, Peng-Cheng Luo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2017.07.038"}], "href": "https://doi.org/10.1016/j.yexcr.2017.07.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28778797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28778797"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Cong Qin, Ming Li, Tao Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2018.08.019"}], "href": "https://doi.org/10.1016/j.yexcr.2018.08.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30121191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30121191"}]}]}]}
Synonyms SPDYE2L
Proteins SPE2B_HUMAN
NCBI Gene ID 100310812
API
Download Associations
Predicted Functions View SPDYE2B's ARCHS4 Predicted Functions.
Co-expressed Genes View SPDYE2B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SPDYE2B's ARCHS4 Predicted Functions.

Functional Associations

SPDYE2B has 678 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 31 datasets.

Click the + buttons to view associations for SPDYE2B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SPDYE2B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SPDYE2B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SPDYE2B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPDYE2B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SPDYE2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SPDYE2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SPDYE2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SPDYE2B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with SPDYE2B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SPDYE2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPDYE2B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SPDYE2B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SPDYE2B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SPDYE2B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GO Molecular Function Annotations 2023 molecular functions performed by SPDYE2B gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by SPDYE2B gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SPDYE2B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SPDYE2B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SPDYE2B gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of SPDYE2B gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of SPDYE2B gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SPDYE2B gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for SPDYE2B protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SPDYE2B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SPDYE2B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SPDYE2B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SPDYE2B gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SPDYE2B gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SPDYE2B gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of SPDYE2B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SPDYE2B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.