{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collected studies focus on the S100A7/psoriasin gene family and its murine homologs, revealing that overexpression of these proteins in breast cancer cells is associated with increased cell proliferation and promotion of proinflammatory signaling. In estrogen receptor–negative breast cancers, S100A7/psoriasin appears to enhance tumor growth and metastasis by upregulating cytokines and chemotactic factors that recruit tumor‐associated macrophages and activate receptors such as RAGE, thereby increasing angiogenesis and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations have provided insights into the cloning and characterization of the murine ortholog of human psoriasin. These studies illustrate that the murine protein is expressed in differentiating keratinocytes, becomes crosslinked by transglutaminase during epidermal maturation, and is implicated in normal skin differentiation as well as in inflammation-associated pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research has linked inflammatory and metabolic signals to enhanced antimicrobial peptide production in the skin, with mediators such as visfatin potentiating the production of psoriasin along with other antimicrobial peptides in keratinocytes. This suggests a role in the pathogenesis of psoriasis by bridging metabolic disorders and chronic cutaneous inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that none of these abstracts provide any data regarding SPDYE4. While the S100A7/psoriasin family is clearly implicated in modulating inflammatory responses, epithelial differentiation, and tumor progression in both breast cancer and skin pathologies, no conclusions about SPDYE4 function can be drawn from these reports.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mohd W Nasser, Zahida Qamri, Yadwinder S Deol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-0669"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-0669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22158945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22158945"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meghan Webb, Ethan D Emberley, Michael Lizardo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-5-17"}], "href": "https://doi.org/10.1186/1471-2407-5-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15717926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15717926"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ronald Wolf, Christopher J Voscopoulos, Peter C FitzGerald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.jid.5700210"}], "href": "https://doi.org/10.1038/sj.jid.5700210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16528363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16528363"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Carren S Hau, Naoko Kanda, Shinji Noda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2013.01.044"}], "href": "https://doi.org/10.1016/j.ajpath.2013.01.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23499548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23499548"}]}]}]}