HGNC Family | Speedy/RINGO cell cycle regulator family (SPDY) |
Name | speedy/RINGO cell cycle regulator family member E4 |
Description | Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Mar 2025] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collected studies focus on the S100A7/psoriasin gene family and its murine homologs, revealing that overexpression of these proteins in breast cancer cells is associated with increased cell proliferation and promotion of proinflammatory signaling. In estrogen receptor–negative breast cancers, S100A7/psoriasin appears to enhance tumor growth and metastasis by upregulating cytokines and chemotactic factors that recruit tumor‐associated macrophages and activate receptors such as RAGE, thereby increasing angiogenesis and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations have provided insights into the cloning and characterization of the murine ortholog of human psoriasin. These studies illustrate that the murine protein is expressed in differentiating keratinocytes, becomes crosslinked by transglutaminase during epidermal maturation, and is implicated in normal skin differentiation as well as in inflammation-associated pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research has linked inflammatory and metabolic signals to enhanced antimicrobial peptide production in the skin, with mediators such as visfatin potentiating the production of psoriasin along with other antimicrobial peptides in keratinocytes. This suggests a role in the pathogenesis of psoriasis by bridging metabolic disorders and chronic cutaneous inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that none of these abstracts provide any data regarding SPDYE4. While the S100A7/psoriasin family is clearly implicated in modulating inflammatory responses, epithelial differentiation, and tumor progression in both breast cancer and skin pathologies, no conclusions about SPDYE4 function can be drawn from these reports.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mohd W Nasser, Zahida Qamri, Yadwinder S Deol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-0669"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-0669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22158945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22158945"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meghan Webb, Ethan D Emberley, Michael Lizardo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-5-17"}], "href": "https://doi.org/10.1186/1471-2407-5-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15717926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15717926"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ronald Wolf, Christopher J Voscopoulos, Peter C FitzGerald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.jid.5700210"}], "href": "https://doi.org/10.1038/sj.jid.5700210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16528363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16528363"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Carren S Hau, Naoko Kanda, Shinji Noda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2013.01.044"}], "href": "https://doi.org/10.1016/j.ajpath.2013.01.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23499548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23499548"}]}]}]}
|
Proteins | SPDE4_HUMAN |
NCBI Gene ID | 388333 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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SPDYE4 has 604 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 28 datasets.
Click the + buttons to view associations for SPDYE4 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SPDYE4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SPDYE4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SPDYE4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with SPDYE4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by SPDYE4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SPDYE4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SPDYE4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPDYE4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of SPDYE4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SPDYE4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of SPDYE4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SPDYE4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by SPDYE4 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SPDYE4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of SPDYE4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for SPDYE4 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SPDYE4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SPDYE4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of SPDYE4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain SPDYE4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of SPDYE4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SPDYE4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SPDYE4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SPDYE4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of SPDYE4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of SPDYE4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SPDYE4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SPDYE4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |