SPON1 Gene

Name	spondin 1, extracellular matrix protein
Description	Predicted to enable LBD domain binding activity and metal ion binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSPON1, also known as F‐spondin, encodes an extracellular matrix protein with a critical role in neural development and function. Structural studies have revealed that its N‐terminal reelin‐N domain displays a variant immunoglobulin‐like fold and heparin‐binding properties, suggesting that dynamic dimerization may modulate its cell adhesion and contact‐repellant functions in guiding axon outgrowth and neuronal migration. Moreover, genome‐wide analyses have identified specific SPON1 variants associated with brain connectivity patterns and cognitive performance, with interactions (for example with APOE) that influence working memory and executive function as well as Alzheimer’s disease risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of skeletal and dental biology, SPON1/F‐spondin has been shown to regulate differentiation processes that are essential for cementum formation and periodontal ligament maturation. Elevated expression of F‐spondin in cementoblast‐like cells promotes mineralization partly via the induction of BMP7 signaling, while its modulation in periodontal tissues also affects osteoclastogenesis and collagen turnover in osteoarthritis cartilage. In addition, genetic studies have linked SPON1 with bone mineral density variations and susceptibility to postmenopausal osteoporosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSPON1 also plays multifaceted roles in cancer biology and drug metabolism. In ovarian, colorectal, and pancreatic cancers, aberrant expression of SPON1 (often originally identified as F‐spondin or vascular smooth muscle growth–promoting factor) has been associated with tumor diagnosis and prognosis, with evidence that its dysregulation may contribute to tumor progression and metastasis—for example, through activation of Fak and Src signaling pathways in osteosarcoma. Beyond oncogenesis, pharmacogenomic studies have implicated SPON1 in the metabolism of methadone, where specific haplotypes account for a significant fraction of the variability in plasma methadone enantiomer levels. Additional bioinformatic screens even suggest a putative role in glioma by virtue of its coexpression with other glioma‐associated genes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kemin Tan, Mark Duquette, Jin-huan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The crystal structure of the heparin-binding reelin-N domain of f-spondin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.06.045"}], "href": "https://doi.org/10.1016/j.jmb.2008.06.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18602404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18602404"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kemin Tan, Jack Lawler "}, {"type": "b", "children": [{"type": "t", "text": "The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Struct Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1472-6807-11-22"}], "href": "https://doi.org/10.1186/1472-6807-11-22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21569239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21569239"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Neda Jahanshad, Priya Rajagopalan, Xue Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1216206110"}], "href": "https://doi.org/10.1073/pnas.1216206110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23471985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23471985"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Richard Sherva, Yorghos Tripodis, David A Bennett, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Brain Mapp (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hbm.24045"}], "href": "https://doi.org/10.1002/hbm.24045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29573041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29573041"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Masae Kitagawa, Yasusei Kudo, Shinji Iizuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.08.142"}], "href": "https://doi.org/10.1016/j.bbrc.2006.08.142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16965763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16965763"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mukundan G Attur, Glyn D Palmer, Hayf E Al-Mussawir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-114363"}], "href": "https://doi.org/10.1096/fj.08-114363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18780763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18780763"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hiroko Oka, Maya Mori, Hisae Kihara "}, {"type": "b", "children": [{"type": "t", "text": "F-spondin inhibits migration and differentiation of osteoclastic precursors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Periodontol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1902/jop.2011.110111"}], "href": "https://doi.org/10.1902/jop.2011.110111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21488757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21488757"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Masae Kitagawa, Min Ao, Mutsumi Miyauchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "F-spondin regulates the differentiation of human cementoblast-like (HCEM) cells via BMP7 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.12.155"}], "href": "https://doi.org/10.1016/j.bbrc.2011.12.155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22244873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22244873"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wenlong Ma, Ke Chen, Wenqing Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of relationship between "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SPON1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene and genetic susceptibility of postmenopausal osteoporosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2020.1771350"}], "href": "https://doi.org/10.1080/21691401.2020.1771350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32484721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32484721"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ruth A Pyle-Chenault, John A Stolk, David A Molesh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VSGP/F-spondin: a new ovarian cancer marker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000087379"}], "href": "https://doi.org/10.1159/000087379"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16103746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16103746"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rheal A Towner, Randy L Jensen, Brian Vaillant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Experimental validation of 5 in-silico predicted glioma biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/not124"}], "href": "https://doi.org/10.1093/neuonc/not124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24158112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24158112"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Heping Chang, Tianhua Dong, Xiaoting Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.05.092"}], "href": "https://doi.org/10.1016/j.bbrc.2015.05.092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26032498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26032498"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hsin-Chou Yang, Shih-Kai Chu, Chieh-Liang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005910"}], "href": "https://doi.org/10.1371/journal.pgen.1005910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27010727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27010727"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Rozita Tamjidifar, Morteza Akbari, Saeed Tarzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastrointest Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12029-019-00356-0"}], "href": "https://doi.org/10.1007/s12029-019-00356-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31927744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31927744"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yanmiao Huo, Jian Yang, Jiahao Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.13237"}], "href": "https://doi.org/10.1111/cpr.13237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35487760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35487760"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ryoya Miyakawa, Makoto Kobayashi, Kotaro Sugimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPON1 is an independent prognostic biomarker for ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-023-01180-8"}], "href": "https://doi.org/10.1186/s13048-023-01180-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37179355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37179355"}]}]}]}
Synonyms	VSGP/F-SPONDIN, F-SPONDIN
Proteins	SPON1_HUMAN
NCBI Gene ID	10418
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SPON1 has 9,303 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for SPON1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SPON1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SPON1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SPON1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SPON1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SPON1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SPON1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SPON1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SPON1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SPON1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SPON1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SPON1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SPON1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SPON1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SPON1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPON1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SPON1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SPON1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SPON1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SPON1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SPON1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SPON1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SPON1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SPON1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SPON1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SPON1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SPON1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SPON1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SPON1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SPON1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SPON1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SPON1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SPON1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SPON1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPON1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SPON1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SPON1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SPON1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SPON1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SPON1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SPON1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SPON1 from the GeneSigDB Published Gene Signatures dataset.