SQSTM1 Gene

Name sequestosome 1
Description This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\np62/SQSTM1 is a multifunctional autophagy receptor that mediates the selective turnover of polyubiquitinated proteins by directly interacting with LC3 on the autophagosomal membrane. Through its highly conserved LC3‐interacting region, p62 facilitates the formation of cytoplasmic inclusion bodies—even large ones—thereby concentrating misfolded proteins and damaged macromolecules into phase‐separated droplets for efficient autophagic degradation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its cargo receptor function, p62 plays a central role in cellular stress responses by modulating the antioxidant defense pathway. By binding Keap1 via a specific KEAP1-interacting region, p62 disrupts Keap1-mediated ubiquitination and proteasomal degradation of Nrf2, thereby promoting the transcriptional activation of cytoprotective genes. Phosphorylation events further enhance this interaction, establishing a positive feedback loop that reinforces the cellular defense against oxidative stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\np62 is further implicated in mitochondrial quality control and innate immunity. In damaged mitochondria, Parkin-mediated ubiquitination triggers the recruitment of p62, which in turn facilitates the aggregation and clustering of depolarized organelles, thereby priming them for mitophagy. Similarly, upon bacterial infection, p62 is recruited to ubiquitinated pathogens, promoting their sequestration into autophagic compartments for eventual degradation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in autophagy and stress response, p62 functions as a versatile signaling hub that interconnects multiple proteostasis and cell survival pathways. It assists in shuttling ubiquitinated substrates to the proteasome and interacts with key mediators of mTORC1 activation, NF-κB signaling, and other metabolic pathways—mechanisms that have been implicated in processes ranging from tumorigenesis to neurodegeneration and Paget disease of bone. Genetic mutations in SQSTM1 underscore its pathological significance, while its interactions with adaptor proteins (e.g., ALFY) and components of the cytoskeleton facilitate the assembly of degradative compartments. Furthermore, p62 undergoes dynamic post-translational modifications and nucleocytoplasmic shuttling that fine-tune its diverse functions in cellular detoxification and signal transduction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M702824200"}], "href": "https://doi.org/10.1074/jbc.M702824200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17580304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17580304"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Geir Bjørkøy, Trond Lamark, Andreas Brech, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200507002"}], "href": "https://doi.org/10.1083/jcb.200507002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16286508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16286508"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Peter Kijun Kim, Dale Warren Hailey, Robert Thomas Mullen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0810611105"}], "href": "https://doi.org/10.1073/pnas.0810611105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19074260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19074260"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Daxiao Sun, Rongbo Wu, Jingxiang Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41422-018-0017-7"}], "href": "https://doi.org/10.1038/s41422-018-0017-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29507397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29507397"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ashish Jain, Trond Lamark, Eva Sjøttem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.118976"}], "href": "https://doi.org/10.1074/jbc.M110.118976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20452972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20452972"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yoshinobu Ichimura, Satoshi Waguri, Yu-Shin Sou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2013.08.003"}], "href": "https://doi.org/10.1016/j.molcel.2013.08.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24011591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24011591"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alexandria Lau, Xiao-Jun Wang, Fei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00248-10"}], "href": "https://doi.org/10.1128/MCB.00248-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20421418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20421418"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yoshinori Katsuragi, Yoshinobu Ichimura, Masaaki Komatsu "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 functions as a signaling hub and an autophagy adaptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.13540"}], "href": "https://doi.org/10.1111/febs.13540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26432171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26432171"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jeganathan Ramesh Babu, Thangiah Geetha, Marie W Wooten "}, {"type": "b", "children": [{"type": "t", "text": "Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2005.03181.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2005.03181.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15953362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15953362"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sven Geisler, Kira M Holmström, Diana Skujat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2012"}], "href": "https://doi.org/10.1038/ncb2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20098416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20098416"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Derek Narendra, Lesley A Kane, David N Hauser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.6.8.13426"}], "href": "https://doi.org/10.4161/auto.6.8.13426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20890124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20890124"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wen-Xing Ding, Hong-Min Ni, Min Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.119537"}], "href": "https://doi.org/10.1074/jbc.M110.119537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20573959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20573959"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kei Okatsu, Keiko Saisho, Midori Shimanuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2010.01426.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2010.01426.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20604804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20604804"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "M Lamar Seibenhener, Jeganathan Ramesh Babu, Thangiah Geetha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.18.8055-8068.2004"}], "href": "https://doi.org/10.1128/MCB.24.18.8055-8068.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15340068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15340068"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yanyong Kang, X Edward Zhou, Xiang Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature14656"}], "href": "https://doi.org/10.1038/nature14656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26200343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26200343"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gen Matsumoto, Koji Wada, Misako Okuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.07.039"}], "href": "https://doi.org/10.1016/j.molcel.2011.07.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22017874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22017874"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yoshihiro Inami, Satoshi Waguri, Ayako Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201102031"}], "href": "https://doi.org/10.1083/jcb.201102031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21482715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21482715"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yiyu T Zheng, Shahab Shahnazari, Andreas Brech, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0900441"}], "href": "https://doi.org/10.4049/jimmunol.0900441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19812211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19812211"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Nancy Laurin, Jacques P Brown, Jean Morissette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/340731"}], "href": "https://doi.org/10.1086/340731"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11992264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11992264"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Angeles Duran, Ramars Amanchy, Juan F Linares, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62 is a key regulator of nutrient sensing in the mTORC1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.06.038"}], "href": "https://doi.org/10.1016/j.molcel.2011.06.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21981924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21981924"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Atsushi Umemura, Feng He, Koji Taniguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.04.006"}], "href": "https://doi.org/10.1016/j.ccell.2016.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27211490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27211490"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Alexandre Puissant, Guillaume Robert, Nina Fenouille, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3537"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20103647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20103647"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Chan Gao, Weipeng Cao, Lan Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2082"}], "href": "https://doi.org/10.1038/ncb2082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20639871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20639871"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jorge Moscat, Michael Karin, Maria T Diaz-Meco "}, {"type": "b", "children": [{"type": "t", "text": "p62 in Cancer: Signaling Adaptor Beyond Autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2016.09.030"}], "href": "https://doi.org/10.1016/j.cell.2016.09.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27768885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27768885"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Mayurbhai Himatbhai Sahani, Eisuke Itakura, Noboru Mizushima "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.27344"}], "href": "https://doi.org/10.4161/auto.27344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24394643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24394643"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Mónika Lippai, Péter Lőw "}, {"type": "b", "children": [{"type": "t", "text": "The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/832704"}], "href": "https://doi.org/10.1155/2014/832704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25013806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25013806"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Terje Høyvarde Clausen, Trond Lamark, Pauline Isakson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.6.3.11226"}], "href": "https://doi.org/10.4161/auto.6.3.11226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20168092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20168092"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Gabriele Zaffagnini, Adriana Savova, Alberto Danieli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62 filaments capture and present ubiquitinated cargos for autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201798308"}], "href": "https://doi.org/10.15252/embj.201798308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29343546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29343546"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Masaaki Komatsu, Shun Kageyama, Yoshinobu Ichimura "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1/A170: physiology and pathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.phrs.2012.07.004"}], "href": "https://doi.org/10.1016/j.phrs.2012.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22841931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22841931"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Tania Valencia, Ji Young Kim, Shadi Abu-Baker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2014.05.004"}], "href": "https://doi.org/10.1016/j.ccr.2014.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25002027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25002027"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Juan F Linares, Angeles Duran, Tomoko Yajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2013.06.020"}], "href": "https://doi.org/10.1016/j.molcel.2013.06.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23911927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23911927"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Victoria Cohen-Kaplan, Ido Livneh, Noa Avni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1615455113"}], "href": "https://doi.org/10.1073/pnas.1615455113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27791183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27791183"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Serhiy Pankiv, Trond Lamark, Jack-Ansgar Bruun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.039925"}], "href": "https://doi.org/10.1074/jbc.M109.039925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20018885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20018885"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Hyunjoo Cha-Molstad, Ki Sa Sung, Joonsung Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3177"}], "href": "https://doi.org/10.1038/ncb3177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26075355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26075355"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Bettina Wurzer, Gabriele Zaffagnini, Dorotea Fracchiolla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.08941"}], "href": "https://doi.org/10.7554/eLife.08941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26413874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26413874"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Weiliang Fan, Zaiming Tang, Dandan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.6.5.12189"}], "href": "https://doi.org/10.4161/auto.6.5.12189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20495340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20495340"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Kathryn M Donaldson, Wei Li, Keith A Ching, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1530212100"}], "href": "https://doi.org/10.1073/pnas.1530212100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12857950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12857950"}]}]}]}
Synonyms PDB3, P62B, FTDALS3, A170, ZIP3, OSIL, NADGP
Proteins SQSTM_HUMAN
NCBI Gene ID 8878
API
Download Associations
Predicted Functions View SQSTM1's ARCHS4 Predicted Functions.
Co-expressed Genes View SQSTM1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SQSTM1's ARCHS4 Predicted Functions.

Functional Associations

SQSTM1 has 28,393 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 147 datasets.

Click the + buttons to view associations for SQSTM1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SQSTM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of SQSTM1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SQSTM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of SQSTM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SQSTM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SQSTM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of SQSTM1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SQSTM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of SQSTM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with SQSTM1 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with SQSTM1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SQSTM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SQSTM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SQSTM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
ClinVar Gene-Phenotype Associations phenotypes associated with SQSTM1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
ClinVar Gene-Phenotype Associations 2025 phenotypes associated with SQSTM1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing SQSTM1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SQSTM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing SQSTM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing SQSTM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores cellular components containing SQSTM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing SQSTM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with SQSTM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SQSTM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
CORUM Protein Complexes protein complexs containing SQSTM1 protein from the CORUM Protein Complexes dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SQSTM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with SQSTM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with SQSTM1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with SQSTM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
dbGAP Gene-Trait Associations traits associated with SQSTM1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of SQSTM1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by SQSTM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Curated Gene-Disease Association Evidence Scores diseases involving SQSTM1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving SQSTM1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with SQSTM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SQSTM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with SQSTM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with SQSTM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SQSTM1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SQSTM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SQSTM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing SQSTM1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with SQSTM1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with SQSTM1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of SQSTM1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with SQSTM1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SQSTM1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SQSTM1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SQSTM1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of SQSTM1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SQSTM1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SQSTM1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of SQSTM1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving SQSTM1 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving SQSTM1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving SQSTM1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing SQSTM1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing SQSTM1 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing SQSTM1 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by SQSTM1 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by SQSTM1 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by SQSTM1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of SQSTM1 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SQSTM1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SQSTM1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations phenotypes associated with SQSTM1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with SQSTM1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
GWASdb SNP-Disease Associations diseases associated with SQSTM1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with SQSTM1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of SQSTM1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of SQSTM1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of SQSTM1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of SQSTM1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPM Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of SQSTM1 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
HPO Gene-Disease Associations phenotypes associated with SQSTM1 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for SQSTM1 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuBMAP ASCT+B Annotations cell types associated with SQSTM1 gene from the HuBMAP ASCT+B dataset.
HuBMAP ASCT+B Augmented with RNA-seq Coexpression cell types associated with SQSTM1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with SQSTM1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for SQSTM1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of SQSTM1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of SQSTM1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SQSTM1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate SQSTM1 protein from the curated KEA Substrates of Kinases dataset.
KEGG Pathways 2026 pathways involving SQSTM1 protein from the KEGG Pathways 2026 dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate SQSTM1 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SQSTM1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SQSTM1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with SQSTM1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SQSTM1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of SQSTM1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of SQSTM1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SQSTM1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain SQSTM1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by SQSTM1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting SQSTM1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SQSTM1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by SQSTM1 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of SQSTM1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of SQSTM1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing SQSTM1 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
OMIM Gene-Disease Associations phenotypes associated with SQSTM1 gene from the curated OMIM Gene-Disease Associations dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for SQSTM1 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SQSTM1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of SQSTM1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving SQSTM1 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving SQSTM1 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with SQSTM1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Phosphosite-Disease Associations diseases associated with SQSTM1 protein from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate SQSTM1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
PID Pathways pathways involving SQSTM1 protein from the PID Pathways dataset.
ProteomicsDB Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of SQSTM1 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset.
Reactome Pathways 2014 pathways involving SQSTM1 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving SQSTM1 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SQSTM1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SQSTM1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SQSTM1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of SQSTM1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SQSTM1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SQSTM1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SQSTM1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SQSTM1 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with SQSTM1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of SQSTM1 gene from the Sci-Plex Drug Perturbation Signatures dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs drug perturbations changing phosphorylation of SQSTM1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands ligand (protein) perturbations changing phosphorylation of SQSTM1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset.
SynGO Synaptic Gene Annotations synaptic terms associated with SQSTM1 gene from the SynGO Synaptic Gene Annotations dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of SQSTM1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of SQSTM1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of SQSTM1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of SQSTM1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SQSTM1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of SQSTM1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SQSTM1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of SQSTM1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SQSTM1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with SQSTM1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SQSTM1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving SQSTM1 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving SQSTM1 protein from the WikiPathways Pathways 2024 dataset.