{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSRCAP is a versatile chromatin‐remodeling factor that plays a pivotal role in transcriptional regulation by facilitating the ATP‐dependent exchange of histone dimers, most notably catalyzing the deposition of the histone variant H2A.Z. Biochemical purification and reconstitution studies have demonstrated that SRCAP forms multiprotein complexes analogous to the yeast SWR-C and that its activity is essential for proper nucleosome composition at both active and inactive promoters, thereby enhancing the recruitment of coactivators such as CBP and boosting hormone‐dependent as well as other signal‐mediated gene transcription. Moreover, SRCAP can functionally complement homologs in model organisms – as seen with its ability to rescue Drosophila DOM mutations and to potentiate Notch signaling – and is implicated in epigenetic reprogramming events following DNA demethylation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central role in chromatin remodeling, SRCAP is critically implicated in human developmental disorders. Truncating mutations predominantly located in the final exons of SRCAP underlie Floating-Harbor syndrome (FHS), a condition marked by short stature, skeletal anomalies, and language delays. These mutations, while sparing the CBP‐binding and ATPase domains, lead to aberrant chromatin and transcriptional regulation that contributes to the overlapping phenotypes observed with related syndromes. Comprehensive clinical and epigenetic studies have further refined genotype–epigenotype–phenotype correlations in SRCAP‐related neurodevelopmental disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its developmental functions, aberrant SRCAP activity is also intricately linked to disease processes such as cancer, viral pathogenesis, and clonal hematopoiesis. In the context of hepatitis C virus infection, SRCAP interacts with the NS3 protein to synergistically activate Notch target genes, suggesting a mechanism by which viral proteins may hijack host chromatin regulators to promote tumorigenesis. Similarly, altered SRCAP expression—whether via dysregulated microRNA networks in breast cancer or through somatic mutations in hematopoietic stem cells that modulate H2A.Z deposition and DNA repair proficiency—underscores its emerging role in cancer cell proliferation and lineage bias."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Alexandra Monroy, Natalie M Schott, Linda Cox, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi060043d"}], "href": "https://doi.org/10.1021/bi060043d"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16634648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16634648"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yong Cai, Jingji Jin, Aaron J Gottschalk, et al. 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