{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSerine racemase (SRR) was initially identified as a diabetes susceptibility gene in genome‐wide association studies, with variants linked to type 2 diabetes mellitus and gestational diabetes. In addition to its cloning and demonstration of active D‐serine production in several peripheral tissues—including placenta and pancreatic cells—SRR has emerged as a candidate contributing to metabolic dysregulation in humans."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the central nervous system, SRR catalyzes the conversion of L‐serine to D‐serine—the critical endogenous co-agonist of N-methyl-D-aspartate (NMDA) receptors that modulates synaptic plasticity, learning, and memory. Alterations in its expression or function have been associated with several neuropsychiatric disorders such as schizophrenia, Alzheimer’s disease progression, and affective dysfunction. Detailed immunohistochemical and functional investigations across different brain regions (including the hippocampus, amygdala, and cortex) underscore the importance of SRR-derived D-serine in mediating NMDA receptor signaling and thereby in the pathophysiology of conditions ranging from NMDA receptor hypofunction to excitotoxic injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExtensive biochemical and structural studies have revealed that SRR exhibits bifunctional activity: it not only racemizes L-serine to form D-serine but also catalyzes an α,β-elimination reaction that degrades both L- and D-serine. This dual-function is regulated by numerous effectors, including ATP, divalent cations, and allosteric ligands such as glycine, which induce conformational rearrangements affecting catalytic specificity and efficiency. Mutagenesis and crystallographic analyses have pinpointed key residues and domains—along with posttranslational modifications like S-nitrosylation—that fine-tune SRR activity, substrate selectivity, and even subcellular localization. These molecular insights provide a structural framework for understanding enzyme inhibition (by substrates, halides, or competing ligands) and for designing potential therapeutic modulators."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical role in neurotransmission, SRR is expressed in a wide array of peripheral tissues—including heart, kidney, skin, and bone—suggesting additional functions in modulating cellular metabolism, differentiation, and stress responses. Altered SRR expression and activity have been linked to osteosarcoma metastasis, retinal neurotoxicity in excitotoxicity models, and even neuroepithelial stem cell dysfunction in Parkinson’s disease, while interactions with regulatory proteins (for example, FBXO22) further influence its localization and function. 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"}, {"type": "b", "children": [{"type": "t", "text": "Serine racemase and D-serine transport in human placenta and evidence for a transplacental gradient for D-serine in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Soc Gynecol Investig (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsgi.2004.02.003"}], "href": "https://doi.org/10.1016/j.jsgi.2004.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15219883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15219883"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Waseem Raza, Jinlei Guo, Muhammad Imran Qadir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "qPCR Analysis Reveals Association of Differential Expression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SRR"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NFKB1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PDE4B"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Genes With Type 2 Diabetes Mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2021.774696"}], "href": "https://doi.org/10.3389/fendo.2021.774696"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35046895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35046895"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Veronika N Foltyn, Inna Bendikov, Joari De Miranda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M405726200"}], "href": "https://doi.org/10.1074/jbc.M405726200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15536068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15536068"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Louise Verrall, Mary Walker, Nancy Rawlings, et al. "}, {"type": "b", "children": [{"type": "t", "text": "d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2007.05769.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2007.05769.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17880399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17880399"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Viviane Labrie, Ryutaro Fukumura, Anjali Rastogi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp261"}], "href": "https://doi.org/10.1093/hmg/ddp261"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19483194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19483194"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2017.08.012"}], "href": "https://doi.org/10.1016/j.biopsych.2017.08.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29025687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29025687"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Misty Thompson, John C Marecki, Stephane Marinesco, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2017.11.013"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2017.11.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29338921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29338921"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sandra Van der Auwera, Alexander Teumer, Johannes Hertel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl-D-aspartate) receptor activation via D-serine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Neuropsychopharmacol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.euroneuro.2016.03.019"}], "href": "https://doi.org/10.1016/j.euroneuro.2016.03.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27394076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27394076"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Myron A Smith, Volker Mack, Andreas Ebneth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.050062"}], "href": "https://doi.org/10.1074/jbc.M109.050062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20106978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20106978"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Florian Baumgart, José M Mancheño, Ignacio Rodríguez-Crespo "}, {"type": "b", "children": [{"type": "t", "text": "Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2007.05986.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2007.05986.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17697119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17697119"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Marialaura Marchetti, Stefano Bruno, Barbara Campanini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of human serine racemase activity and dynamics by halides, ATP and malonate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-014-1856-2"}], "href": "https://doi.org/10.1007/s00726-014-1856-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25331425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25331425"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Stefano Bruno, Marilena Margiotta, Francesco Marchesani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Proteins Proteom (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbapap.2017.01.001"}], "href": "https://doi.org/10.1016/j.bbapap.2017.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28089597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28089597"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "David L Nelson, Greg A Applegate, Matthew L Beio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M117.777904"}], "href": "https://doi.org/10.1074/jbc.M117.777904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28696262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28696262"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Andrea V Canosa, Serena Faggiano, Marialaura Marchetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-27227-1"}], "href": "https://doi.org/10.1038/s41598-018-27227-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29899358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29899358"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Neta Nitoker, Dan Thomas Major "}, {"type": "b", "children": [{"type": "t", "text": "Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi500984m"}], "href": "https://doi.org/10.1021/bi500984m"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25493718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25493718"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Francesco Marchesani, Eleonora Gianquinto, Ida Autiero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.15645"}], "href": "https://doi.org/10.1111/febs.15645"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33249721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33249721"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Wei Wang, Steven W Barger "}, {"type": "b", "children": [{"type": "t", "text": "Roles of quaternary structure and cysteine residues in the activity of human serine racemase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2091-12-63"}], "href": "https://doi.org/10.1186/1471-2091-12-63"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22151352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22151352"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Cyong-Yi Wang, Shan Chi Ku, Cheng-Chung Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulating the function of human serine racemase and human serine dehydratase by protein engineering."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Eng Des Sel (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/protein/gzs078"}], "href": "https://doi.org/10.1093/protein/gzs078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23112234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23112234"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Hua Tao, Xu Zhou, Qian Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13473"}], "href": "https://doi.org/10.1111/jcmm.13473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29363864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29363864"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Youguang Pu, Fangfang Zhao, Wenjing Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-016-9783-0"}], "href": "https://doi.org/10.1007/s10585-016-9783-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26913720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26913720"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Elena Dikopoltsev, Veronika N Foltyn, Martin Zehl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.618405"}], "href": "https://doi.org/10.1074/jbc.M114.618405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25336657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25336657"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Haiyan Jiang, Xianwei Wang, He Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.13400"}], "href": "https://doi.org/10.1111/jnc.13400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26485193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26485193"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Sarah Louise Nickels, Jonas Walter, Silvia Bolognin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Parkinsonism Relat Disord (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.parkreldis.2019.09.018"}], "href": "https://doi.org/10.1016/j.parkreldis.2019.09.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31621607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31621607"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Yoko Yoshihisa, Mati Ur Rehman, Maho Nakagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammatory cytokine-mediated induction of serine racemase in atopic dermatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13592"}], "href": "https://doi.org/10.1111/jcmm.13592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29566294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29566294"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Chuan Lan, Yo-Ichi Yamashita, Masayo Tsukamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Prognostic Role of Serine Racemase in Patients With Pancreatic Cancer: A New Marker in Cancer Metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pancreas (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPA.0000000000002210"}], "href": "https://doi.org/10.1097/MPA.0000000000002210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37523600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37523600"}]}]}]}