SRSF2 Gene

HGNC Family	Serine/arginine-rich splicing factors (SRSF), RNA binding motif containing (RBM)
Name	serine/arginine-rich splicing factor 2
Description	The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSRSF2 is a critical serine/arginine‐rich splicing factor whose normal function in regulating constitutive and alternative pre‐mRNA splicing is subverted in several hematologic malignancies. Recurrent, often early‐occurring mutations – most notably alterations at codon P95 – have been reported in secondary and therapy‐related acute myeloid leukemia, myelodysplastic syndromes, chronic myelomonocytic leukemia, myeloproliferative neoplasms undergoing leukemic transformation, and primary myelofibrosis. These mutations frequently alter SRSF2’s RNA binding specificity and are associated with misregulated exon inclusion/exclusion events that contribute to poor clinical outcomes and may serve as useful diagnostic or prognostic markers in these diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in disease, normal SRSF2 (historically also designated SC35) contributes to the architectural and functional integrity of nuclear speckles and engages in highly specific RNA interactions that modulate splice site selection. Functional studies – including CRISPR‐mediated introduction of SRSF2 missense mutations – have demonstrated that altered RNA binding affinity drives a cascade of splicing misregulation events. Moreover, SRSF2’s activity and stability are further controlled by post‐translational modifications such as acetylation by Tip60 and regulation of its nucleocytoplasmic shuttling, which in turn impact the processing of key apoptotic and cell cycle mRNAs. These mechanistic insights also derive from work in systems ranging from viral RNA splicing (where differential antagonism of RNA binding is observed) to analyses of nuclear compartment organization and caffeine‐induced splicing regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond hematologic disorders, deregulated expression and function of SRSF2 have been implicated in solid tumor biology and viral oncogenesis. In hepatocellular carcinoma and uveal melanoma, for example, aberrant SRSF2 levels and change‐of‐function mutations promote alternative splicing events that favor oncogenic isoforms and enhance cell proliferation, while in the context of human papillomavirus infection SRSF2 helps maintain oncoprotein mRNA stability. Moreover, recent studies indicate that SRSF2 mutations may trigger wider “splicing‐cascade” effects by dysregulating other RNA processing factors and contributing to chemoresistance through impacts on apoptosis‐regulating transcripts. These observations highlight the wide-ranging impact of SRSF2 on transcriptome integrity and underscore its potential as a therapeutic target in multiple malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "22"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_fs", "start_ref": "23", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hideki Makishima, Valeria Visconte, Hirotoshi Sakaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-12-399774"}], "href": "https://doi.org/10.1182/blood-2011-12-399774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22323480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22323480"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Felicitas Thol, Sofia Kade, Carola Schlarmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-12-399337"}], "href": "https://doi.org/10.1182/blood-2011-12-399337"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22389253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22389253"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Su-Jiang Zhang, Raajit Rampal, Taghi Manshouri, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The cisplatin-induced lncRNA PANDAR dictates the chemoresistance of ovarian cancer via regulating SFRS2-mediated p53 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-1148-y"}], "href": "https://doi.org/10.1038/s41419-018-1148-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30375398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30375398"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ilenia Pellarin, Alessandra Dall'Acqua, Alice Gambelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-1292-6"}], "href": "https://doi.org/10.1038/s41388-020-1292-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32332923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32332923"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Stefanos A Bamopoulos, Aarif M N Batcha, Vindi Jurinovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-020-0839-4"}], "href": "https://doi.org/10.1038/s41375-020-0839-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32358566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32358566"}]}]}]}
Synonyms	PR264, SFRS2A, SC-35, SC35, SFRS2, SRP30B
Proteins	SRSF2_HUMAN
NCBI Gene ID	6427
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SRSF2 has 12,065 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for SRSF2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SRSF2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SRSF2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRSF2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRSF2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SRSF2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SRSF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SRSF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRSF2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving SRSF2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SRSF2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRSF2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRSF2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SRSF2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SRSF2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SRSF2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SRSF2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRSF2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SRSF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SRSF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SRSF2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SRSF2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SRSF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SRSF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SRSF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SRSF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SRSF2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SRSF2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SRSF2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SRSF2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SRSF2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DGIdb Drug Targets 2026	interacting drugs for SRSF2 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SRSF2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SRSF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SRSF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SRSF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SRSF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SRSF2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRSF2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SRSF2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SRSF2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SRSF2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.