SRSF5 Gene

HGNC Family	RNA binding motif containing (RBM), Serine/arginine-rich splicing factors (SRSF)
Name	serine/arginine-rich splicing factor 5
Description	The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSRSF5 is emerging as a key splicing regulator that integrates into the supraspliceosome to modulate alternative splicing decisions. In particular, elevated levels of SRSF5 have been shown to influence the splicing patterns of several pre‐mRNAs, thereby impacting the production of distinct protein isoforms in response to cellular cues. For example, modification of supraspliceosomal activity and changes in alternative splicing events have been observed to correlate with the upregulation of SRSF5, underscoring its central role in pre‐mRNA processing and transcriptome diversity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of tumorigenesis, SRSF5 has been implicated as an oncogenic splicing factor. Upon glucose intake, SRSF5 becomes specifically induced via Tip60‐mediated acetylation, thereby promoting the alternative splicing of CCAR1 to generate isoforms that enhance glucose consumption and accelerate tumor growth. Elevated expression of SRSF5 is also found in oral squamous cell carcinoma, where it is upregulated by oncogenic signals such as SRSF3, and in non–small-cell lung cancer, where its overexpression sustains cell proliferation by promoting glycolysis through increased PKM2 expression. Furthermore, its diagnostic relevance in lung cancer has been explored through the evaluation of SRSF5 protein levels in pleural effusion specimens."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer metabolism and growth, SRSF5 shows dynamic post‐translational modulation that governs its nucleocytoplasmic shuttling and splicing activity in response to environmental stresses. In pluripotent cells, enhanced arginine methylation and reduced phosphorylation levels facilitate SRSF5 shuttling, thereby promoting the export of key pluripotency transcripts such as Lin28a and Oct4. Moreover, under mild hypothermia and other forms of cellular stress, upregulation of SRSF5 stimulates the production of splice variants such as p19 H‐RAS that modulate chemosensitivity. Notably, in models of Hutchinson–Gilford progeria syndrome, increased expression of SRSF5 has been demonstrated to counteract aberrant splicing of LMNA pre‐mRNA by favoring the utilization of the normal 5′ splice site over the cryptic progerin site, suggesting potential therapeutic avenues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naama Sebbag-Sznajder, Oleg Raitskin, Minna Angenitzki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of alternative splicing within the supraspliceosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Struct Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsb.2011.11.005"}], "href": "https://doi.org/10.1016/j.jsb.2011.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22100336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22100336"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hak-Ryul Kim, Gyeong-Ok Lee, Keum-Ha Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2016.05.018"}], "href": "https://doi.org/10.1016/j.lungcan.2016.05.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27565915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27565915"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sisi Yang, Rong Jia, Zhuan Bian "}, {"type": "b", "children": [{"type": "t", "text": "SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2018.05.017"}], "href": "https://doi.org/10.1016/j.bbamcr.2018.05.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29857020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29857020"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuhan Chen, Qingyang Huang, Wen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-04815-3"}], "href": "https://doi.org/10.1038/s41467-018-04815-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29942010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29942010"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jiliang Yan, Dongya Zhang, Yanjie Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28992"}], "href": "https://doi.org/10.1002/jcb.28992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31106485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31106485"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Takanori Fujita, Hiroaki Higashitsuji, Hisako Higashitsuji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-02473-x"}], "href": "https://doi.org/10.1038/s41598-017-02473-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28536481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28536481"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Valentina Botti, François McNicoll, Michaela C Steiner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular differentiation state modulates the mRNA export activity of SR proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201610051"}], "href": "https://doi.org/10.1083/jcb.201610051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28592444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28592444"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mengyang Zhang, Chunqing Yang, Xuelei Ruan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-022-03878-9"}], "href": "https://doi.org/10.1038/s42003-022-03878-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36064747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36064747"}]}]}]}
Synonyms	SFRS5, SRP40
Proteins	SRSF5_HUMAN
NCBI Gene ID	6430
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SRSF5 has 8,210 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for SRSF5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SRSF5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRSF5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SRSF5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SRSF5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRSF5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SRSF5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRSF5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRSF5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SRSF5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SRSF5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SRSF5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SRSF5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRSF5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SRSF5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SRSF5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SRSF5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SRSF5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SRSF5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SRSF5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SRSF5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SRSF5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SRSF5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SRSF5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SRSF5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SRSF5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SRSF5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SRSF5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SRSF5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SRSF5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SRSF5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SRSF5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SRSF5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SRSF5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SRSF5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRSF5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SRSF5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SRSF5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SRSF5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SRSF5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SRSF5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SRSF5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.