{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSRSF6 has emerged as a pivotal regulator of alternative splicing with profound implications in cancer biology. In colorectal cancer, for example, SRSF6 promotes epithelial–mesenchymal transition (EMT) and metastasis—acting even independently of its lncRNA inhibitor LINC01133—while gene amplification‐driven over‐expression in colon and lung tumors enhances proliferation, chemoresistance, and tumorigenicity through splicing modulation of key oncogenes and tumor suppressors. Its aberrant expression is also linked to changes in extracellular matrix components in skin and breast cancers as evidenced by altered splicing of tenascin C and CD44, and SRSF6 upregulation in pleural mesothelial cells contributes to fibrotic remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neural contexts, SRSF6 (also known as SRp55) regulates splicing events that are crucial for proper neuronal function. It promotes the inclusion of Tau exon 10, thereby helping to maintain the balance between isoforms with three or four microtubule‐binding repeats—a balance that is critical for preventing tau aggregation and neurodegeneration. Moreover, altered SRSF6‐driven splicing has been linked to pathological changes in Huntington’s disease, although experimental depletion of SRSF6 in Huntington’s models did not modulate incomplete splicing of the HTT transcript, highlighting the selective nature of its regulatory roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSRSF6 also functions in the regulation of viral RNA processing. In HIV‐1 replication, SRSF6 is one of the SR proteins that not only enhances Gag protein translation from unspliced genomic RNA but also fine‐tunes viral gene expression by binding to splicing enhancer elements. This binding activity modulates the splicing pattern of viral transcripts and thereby influences the relative production of regulatory proteins such as Vpr, Tat, and Env."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in modulating cell proliferation and viral gene expression, SRSF6 is crucial for the alternative splicing of mRNAs that encode secreted factors and apoptosis regulators. It binds to exonic splice enhancers within the calcitonin/CGRP pre-mRNA to favor calcitonin mRNA production, modulates the splicing of pro‐ and anti‐apoptotic genes such as Fas, and affects the generation of isoforms of Bim and Bcl‑x that determine cell fate. Additionally, SRSF6 overexpression in cancer cells has been shown to alter splicing programs related to the DNA damage response."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn metabolic and degenerative diseases, SRSF6 has critical regulatory functions. In pancreatic β‑cells, it modulates splicing of genes important for cell survival and insulin secretion—functions that are interlinked with diabetes susceptibility. In cardiac tissues from individuals with Down syndrome, altered phosphorylation of SRSF6 is associated with a reversion to fetal splicing patterns of cardiac genes such as TNNT2. Furthermore, antisense oligonucleotides targeting splicing defects mediated by SRSF6 can restore normal splicing in dopa decarboxylase deficiency, and genetic variations in SRSF6 have been implicated in predisposition to systemic sclerosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent findings further reveal that SRSF6 plays a dynamic role in the cellular stress response. Under acute hypoxia, for instance, inclusion of a poison cassette exon—promoted by SRSF4—leads to a marked reduction in SRSF6 levels, contributing to both exon skipping and dispersal of nuclear speckles. This adaptive response may be critical in reprogramming gene expression to cope with stress, and emerging data even suggest that SRSF6‐related pathways might trigger genetic compensation mechanisms in tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianlu Kong, Wenjie Sun, Chen Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gutjnl-2017-314983"}], "href": "https://doi.org/10.1136/gutjnl-2017-314983"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29114070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29114070"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Feifei Zhang, Hui Wang, Jiang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-020-01299-y"}], "href": "https://doi.org/10.1186/s12943-020-01299-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33397371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33397371"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yalu Zhou, Cuijuan Han, Eric Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-19-1436"}], "href": "https://doi.org/10.1158/2159-8290.CD-19-1436"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32444465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32444465"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fritz Lai, Chen Chen Jiang, Margaret L Farrelly, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Splicing factor SRSF6 mediates pleural fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.146197"}], "href": "https://doi.org/10.1172/jci.insight.146197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33905374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33905374"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiaomin Yin, Nana Jin, Jianlan Gu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2008.05.008"}], "href": "https://doi.org/10.1016/j.gene.2008.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18571879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18571879"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hirokazu Hara, Tatsuya Takeda, Nozomi Yamamoto, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SRSF6 regulates alternative splicing of genes involved in DNA damage response and DNA repair in HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7750"}], "href": "https://doi.org/10.3892/or.2020.7750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32901876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32901876"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.202000825"}], "href": "https://doi.org/10.26508/lsa.202000825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33376132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33376132"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Adolfo Quiñones-Lombraña, Javier G Blanco "}, {"type": "b", "children": [{"type": "t", "text": "Comparative analysis of the DYRK1A-SRSF6-TNNT2 pathway in myocardial tissue from individuals with and without Down syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2019.104268"}], "href": "https://doi.org/10.1016/j.yexmp.2019.104268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31201803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31201803"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Chi-Ren Tsai, Hsiu-Fen Lee, Ching-Shiang Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antisense oligonucleotides modulate dopa decarboxylase function in aromatic l-amino acid decarboxylase deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23659"}], "href": "https://doi.org/10.1002/humu.23659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30260058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30260058"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Eloisa Romano, Irene Rosa, Bianca Saveria Fioretto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A candidate gene study reveals association between a variant of the SRp55 splicing factor gene and systemic sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Rheumatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.55563/clinexprheumatol/mpgq0y"}], "href": "https://doi.org/10.55563/clinexprheumatol/mpgq0y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34665708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34665708"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Camila de Oliveira Freitas Machado, Michal Schafranek, Mirko Brüggemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac1225"}], "href": "https://doi.org/10.1093/nar/gkac1225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36620874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36620874"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Weimin Xu, Weijun Ou, Yuan Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol Hepatol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jgh.16152"}], "href": "https://doi.org/10.1111/jgh.16152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36807382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36807382"}]}]}]}