{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSSB (also known as the La autoantigen) is a multifaceted RNA‐binding protein essential for RNA metabolism. In the nucleus it specifically recognizes the 3′ UUU–OH motifs of nascent RNA polymerase III transcripts—including pre–tRNAs and 5S rRNA precursors—thereby protecting these RNAs from exonucleolytic decay and facilitating proper RNA folding through RNA chaperone activity. Moreover, SSB regulates the biogenesis and function of several small regulatory RNAs, including pre–microRNAs, by binding to their structured elements and influencing subsequent maturation events. Such activities are critical not only for accurate tRNA processing but also for maintaining the integrity of cellular RNA pools that govern protein synthesis and gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its housekeeping role in RNA maturation, SSB exerts pivotal functions during viral infections. It directly binds to highly structured viral RNA elements such as internal ribosome entry sites (IRES) and untranslated regions in pathogens including hepatitis C virus, Coxsackievirus, and Japanese encephalitis virus. In doing so, SSB modulates viral translation and genome replication by either competing with or cooperating with other host factors, thus influencing the switch between translation and replication of viral RNAs. Such interactions may also affect nuclear–cytoplasmic shuttling and the assembly of viral ribonucleoprotein complexes, thereby impacting the overall efficiency of the viral life cycle."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in RNA processing and viral gene regulation, SSB is implicated in diverse cellular pathways that impact disease. Its aberrant expression or misregulation has been linked to autoimmune disorders such as Sjögren’s syndrome and systemic lupus erythematosus, where SSB serves as a major autoantigen. Furthermore, by modulating IRES‐mediated translation of critical cell cycle and survival mRNAs (for example, those encoding cyclin D1 and Bcl2) and by influencing RNA interference and stress responses, SSB contributes to oncogenic transformation and chemoresistance. In some contexts, SSB-mediated opsonization of apoptotic cells also appears to trigger inflammatory cascades, further underlining its importance in health and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "38"}, {"type": "fg_f", "ref": "24"}, {"type": "fg_fs", "start_ref": "39", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Robert V Intine, Miroslav Dundr, Tom Misteli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(02)00533-6"}], "href": "https://doi.org/10.1016/s1097-2765(02"}, {"type": "t", "text": "00533-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12049746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12049746"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Robert V Intine, Scott A Tenenbaum, Amy L Sakulich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00429-5"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00429-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14636586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14636586"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Caterina Alfano, Domenico Sanfelice, Jeff Babon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb747"}], "href": "https://doi.org/10.1038/nsmb747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15004549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15004549"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elena I Schwartz, Robert V Intine, Richard J Maraia "}, {"type": "b", "children": [{"type": "t", "text": "CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.21.9580-9591.2004"}], "href": "https://doi.org/10.1128/MCB.24.21.9580-9591.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15485924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15485924"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Robert V Intine, Miroslav Dundr, Alex Vassilev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.24.10894-10904.2004"}], "href": "https://doi.org/10.1128/MCB.24.24.10894-10904.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15572691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15572691"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marianna Teplova, Yu-Ren Yuan, Anh Tuân Phan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.10.027"}], "href": "https://doi.org/10.1016/j.molcel.2005.10.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16387655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16387655"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mark A Bayfield, Trish E Kaiser, Robert V Intine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00026-07"}], "href": "https://doi.org/10.1128/MCB.00026-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17308035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17308035"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mark A Bayfield, Richard J Maraia "}, {"type": "b", "children": [{"type": "t", "text": "Precursor-product discrimination by La protein during tRNA metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1573"}], "href": "https://doi.org/10.1038/nsmb.1573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19287396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19287396"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Amir R Naeeni, Maria R Conte, Mark A Bayfield "}, {"type": "b", "children": [{"type": "t", "text": "RNA chaperone activity of human La protein is mediated by variant RNA recognition motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.276071"}], "href": "https://doi.org/10.1074/jbc.M111.276071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22203678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22203678"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chunyang Liang, Ke Xiong, Keith E Szulwach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.401323"}], "href": "https://doi.org/10.1074/jbc.M112.401323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23129761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23129761"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sven Horke, Kerstin Reumann, Andreas Rang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of the human La protein.hepatitis B virus RNA.B interaction in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201911200"}], "href": "https://doi.org/10.1074/jbc.M201911200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12121976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12121976"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Partho Sarothi Ray, Saumitra Das "}, {"type": "b", "children": [{"type": "t", "text": "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkf583"}], "href": "https://doi.org/10.1093/nar/gkf583"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12384597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12384597"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Renuka Pudi, Saraswathi Abhiman, Narayanaswamy Srinivasan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis C virus internal ribosome entry site-mediated translation is stimulated by specific interaction of independent regions of human La autoantigen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M210287200"}], "href": "https://doi.org/10.1074/jbc.M210287200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12540850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12540850"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rosa Martha E Yocupicio-Monroy, Fernando Medina, Jorge Reyes-del Valle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular proteins from human monocytes bind to dengue 4 virus minus-strand 3' untranslated region RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.77.5.3067-3076.2003"}], "href": "https://doi.org/10.1128/jvi.77.5.3067-3076.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12584332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12584332"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Beatriz María García-Montalvo, Fernando Medina, Rosa M del Angel "}, {"type": "b", "children": [{"type": "t", "text": "La protein binds to NS5 and NS3 and to the 5' and 3' ends of Dengue 4 virus RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virus Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virusres.2004.01.024"}], "href": "https://doi.org/10.1016/j.virusres.2004.01.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15084396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15084396"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Angela M Domitrovich, Kevin W Diebel, Naushad Ali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2005.02.009"}], "href": "https://doi.org/10.1016/j.virol.2005.02.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15823607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15823607"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Victor Fok, Kyle Friend, Joan A Steitz "}, {"type": "b", "children": [{"type": "t", "text": "Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200601026"}], "href": "https://doi.org/10.1083/jcb.200601026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16682524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16682524"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Susann Cordes, Yuri Kusov, Tilman Heise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "La autoantigen suppresses IRES-dependent translation of the hepatitis A virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.01.163"}], "href": "https://doi.org/10.1016/j.bbrc.2008.01.163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18282467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18282467"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Surender Vashist, Manu Anantpadma, Himani Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Virol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/vir.0.010850-0"}], "href": "https://doi.org/10.1099/vir.0.010850-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19264640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19264640"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Takayoshi Shirasaki, Masao Honda, Hideki Mizuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Infect Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/653081"}], "href": "https://doi.org/10.1086/653081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20497049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20497049"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Surender Vashist, Deepika Bhullar, Sudhanshu Vrati "}, {"type": "b", "children": [{"type": "t", "text": "La protein can simultaneously bind to both 3'- and 5'-noncoding regions of Japanese encephalitis virus genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2010.1114"}], "href": "https://doi.org/10.1089/dna.2010.1114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21294637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21294637"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Upasana Ray, Saumitra Das "}, {"type": "b", "children": [{"type": "t", "text": "Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep00001"}], "href": "https://doi.org/10.1038/srep00001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22355520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22355520"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Anuj Kumar, Upasana Ray, Saumitra Das "}, {"type": "b", "children": [{"type": "t", "text": "Human La protein interaction with GCAC near the initiator AUG enhances hepatitis C Virus RNA replication by promoting linkage between 5' and 3' untranslated regions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00525-13"}], "href": "https://doi.org/10.1128/JVI.00525-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23552417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23552417"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Shivaprasad Shwetha, Anuj Kumar, Ranajoy Mullick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3' Untranslated Region and Enhances Hepatitis C Virus Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01714-15"}], "href": "https://doi.org/10.1128/JVI.01714-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26339049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26339049"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Richard J Maraia, Sandy Mattijssen, Isabel Cruz-Gallardo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Wiley Interdiscip Rev RNA (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/wrna.1430"}], "href": "https://doi.org/10.1002/wrna.1430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28782243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28782243"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Imke Ehlers, Sven Horke, Kerstin Reumann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of the interaction between human La and hepatitis B virus RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402227200"}], "href": "https://doi.org/10.1074/jbc.M402227200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15302879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15302879"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Aurélia Belisova, Katharina Semrad, Oliver Mayer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA chaperone activity of protein components of human Ro RNPs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.7263905"}], "href": "https://doi.org/10.1261/rna.7263905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15928345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15928345"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Petra J Neufing, Robert M Clancy, Michael W Jackson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.21486"}], "href": "https://doi.org/10.1002/art.21486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16320341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16320341"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Robert M Clancy, Petra J Neufing, Ping Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI27803"}], "href": "https://doi.org/10.1172/JCI27803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16906225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16906225"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Fares Al-Ejeh, Jocelyn M Darby, Michael P Brown "}, {"type": "b", "children": [{"type": "t", "text": "The La autoantigen is a malignancy-associated cell death target that is induced by DNA-damaging drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-07-0922"}], "href": "https://doi.org/10.1158/1078-0432.CCR-07-0922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17875783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17875783"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Antonio Brucato, Chiara Grava, Maria Bortolati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Rheumatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3899/jrheum.080737"}], "href": "https://doi.org/10.3899/jrheum.080737"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19567621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19567621"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Alexander R Langley, Helen Chambers, Christo P Christov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribonucleoprotein particles containing non-coding Y RNAs, Ro60, La and nucleolin are not required for Y RNA function in DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0013673"}], "href": "https://doi.org/10.1371/journal.pone.0013673"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21060685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21060685"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "M Nakatake, B Monte-Mor, N Debili, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.313"}], "href": "https://doi.org/10.1038/onc.2011.313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21785463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21785463"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Luigi Martino, Simon Pennell, Geoff Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkr890"}], "href": "https://doi.org/10.1093/nar/gkr890"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22009680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22009680"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Ying Liu, Huiling Tan, Hui Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RISC catalysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.09.011"}], "href": "https://doi.org/10.1016/j.molcel.2011.09.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22055194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22055194"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "E J ter Borg, J C Kelder "}, {"type": "b", "children": [{"type": "t", "text": "Lower prevalence of extra-glandular manifestations and anti-SSB antibodies in patients with primary Sjögren's syndrome and widespread pain: evidence for a relatively benign subset."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Rheumatol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24529195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24529195"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Julia Kuehnert, Gunhild Sommer, Avery W Zierk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku1309"}], "href": "https://doi.org/10.1093/nar/gku1309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25520193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25520193"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "S Katsiougiannis, R Tenta, F N Skopouli "}, {"type": "b", "children": [{"type": "t", "text": "Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the autoantigens Ro/Sjögren's syndrome-related antigen A (SSA) and La/SSB in salivary gland epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cei.12638"}], "href": "https://doi.org/10.1111/cei.12638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25845745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25845745"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Tilman Heise, Venkatesh Kota, Alexander Brock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8819"}], "href": "https://doi.org/10.18632/oncotarget.8819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27105491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27105491"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Daniele Hasler, Gerhard Lehmann, Yasuhiro Murakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2016.05.026"}], "href": "https://doi.org/10.1016/j.molcel.2016.05.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27345152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27345152"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Kerene A Brown, Samel Sharifi, Rawaa Hussain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.6b00995"}], "href": "https://doi.org/10.1021/acs.biochem.6b00995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27959512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27959512"}]}]}]}