SSBP1 Gene

Name	single-stranded DNA binding protein 1, mitochondrial
Description	SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMitochondrial single‐stranded DNA binding protein 1 (SSBP1) is a key factor in the maintenance and replication of the mitochondrial genome. It binds to single‐stranded DNA to stimulate the enzymatic activities of DNA polymerase γ and the mitochondrial helicase, ensuring proper replication and the integrity of mitochondrial nucleoids—including the maintenance of short DNA species such as 7S DNA. In addition, SSBP1 participates in adaptive cellular responses by translocating to the nucleus under proteotoxic stress, where its interaction with stress‐responsive transcription factors modulates chaperone gene expression. Disruption of these processes through mutations that affect SSBP1 multimer formation has been linked to mitochondrial DNA depletion syndromes and optic atrophy clinical phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in mitochondrial DNA synthesis, SSBP1 contributes to mitochondrial DNA repair and epigenetic regulation. It physically interacts with the tumor suppressor p53, enhancing its intrinsic exonuclease activity to facilitate the removal of oxidatively damaged bases. Moreover, SSBP1 has been identified as a putative binding partner for N6-methyldeoxyadenosine (6mA), thus linking methylation dynamics with the regulation of mitochondrial replication, while also modulating the activities of base excision repair enzymes to protect single-stranded DNA from deleterious processing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSSBP1 also plays roles that bridge mitochondrial function with extramitochondrial processes and disease states. During viral reactivation—as in Epstein–Barr virus lytic replication—SSBP1 interacts with viral transcription factors to support viral genome synthesis while concurrently curtailing mitochondrial DNA replication. Additionally, SSBP1 is implicated in the regulation of mitochondrial RNA metabolism through its association with key components of RNA granules, and its altered expression and function have been linked to disease processes including inherited optic neuropathies and various cancers, where aberrant SSBP1 levels correlate with enhanced mitochondrial biogenesis, cellular proliferation, and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDetailed biophysical analyses have further shed light on the mechanisms by which SSBP1 interacts with single-stranded DNA. Kinetic and thermodynamic studies reveal that SSBP1 binds ssDNA in distinct modes that are modulated by salt and magnesium concentration, reflecting its aptitude to dynamically organize the mitochondrial genome during replication and repair. Single-molecule and optical tweezers experiments have illustrated that SSBP1-mediated DNA wrapping and direct transfer between DNA substrates underlie its capacity to both protect exposed ssDNA and facilitate its accessibility for replication and other enzymatic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ke Tan, Mitsuaki Fujimoto, Ryosuke Takii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7580"}], "href": "https://doi.org/10.1038/ncomms7580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25762445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25762445"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoli Cheng, Tomotake Kanki, Atsushi Fukuoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvi169"}], "href": "https://doi.org/10.1093/jb/mvi169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16428295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16428295"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Valentina Del Dotto, Farid Ullah, Ivano Di Meo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI128514"}], "href": "https://doi.org/10.1172/JCI128514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31550240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31550240"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Heini Ruhanen, Sarah Borrie, Gyorgy Szabadkai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2010.04.008"}], "href": "https://doi.org/10.1016/j.bbamcr.2010.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20434493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20434493"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Camille Piro-Mégy, Emmanuelle Sarzi, Aleix Tarrés-Solé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI128513"}], "href": "https://doi.org/10.1172/JCI128513"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31550237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31550237"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marcos T Oliveira, Laurie S Kaguni "}, {"type": "b", "children": [{"type": "t", "text": "Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.289983"}], "href": "https://doi.org/10.1074/jbc.M111.289983"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21953457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21953457"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Neringa Jurkute, Costin Leu, Hans-Martin Pogoda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SSBP1 mutations in dominant optic atrophy with variable retinal degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.25550"}], "href": "https://doi.org/10.1002/ana.25550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31298765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31298765"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tuck Seng Wong, Sridharan Rajagopalan, Fiona M Townsley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkn974"}], "href": "https://doi.org/10.1093/nar/gkn974"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19066201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19066201"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Casslynn W Q Koh, Yeek Teck Goh, Joel D W Toh, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx395"}], "href": "https://doi.org/10.1093/nar/gkx395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28486639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28486639"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Andreas Wiedmer, Pu Wang, Jing Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epstein-Barr virus immediate-early protein Zta co-opts mitochondrial single-stranded DNA binding protein to promote viral and inhibit mitochondrial DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02198-07"}], "href": "https://doi.org/10.1128/JVI.02198-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18305033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18305033"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fenna Hensen, Alisa Potter, Selma L van Esveld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz047"}], "href": "https://doi.org/10.1093/nar/gkz047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30715486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30715486"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Margaret A Gustafson, Eric D Sullivan, William C Copeland "}, {"type": "b", "children": [{"type": "t", "text": "Consequences of compromised mitochondrial genome integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2020.102916"}], "href": "https://doi.org/10.1016/j.dnarep.2020.102916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33087282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33087282"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yong Chun Chong, Randall K Mann, Chen Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.252676.114"}], "href": "https://doi.org/10.1101/gad.252676.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25644602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25644602"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jian Huang, Zheng-Fu Xie "}, {"type": "b", "children": [{"type": "t", "text": "Identification of SSBP1 as a prognostic marker in human lung adenocarcinoma using bioinformatics approaches."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Math Biosci Eng (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3934/mbe.2022139"}], "href": "https://doi.org/10.3934/mbe.2022139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35240818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35240818"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiang Zhao, Rong He, Yu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UPregulated single-stranded DNA-binding protein 1 induces cell chemoresistance to cisplatin in lung cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-2970-8"}], "href": "https://doi.org/10.1007/s11010-017-2970-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28210897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28210897"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yufeng Qian, Kenneth A Johnson "}, {"type": "b", "children": [{"type": "t", "text": "The human mitochondrial single-stranded DNA-binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M117.791392"}], "href": "https://doi.org/10.1074/jbc.M117.791392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28615444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28615444"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Robert L Eoff, Kevin D Raney "}, {"type": "b", "children": [{"type": "t", "text": "A catch and release program for single-stranded DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.H117.791392"}], "href": "https://doi.org/10.1074/jbc.H117.791392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28778884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28778884"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "José A Morin, Fernando Cerrón, Francisco J Cao-García, et al. 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Synonyms	SOSS-B1, MTSSB, MT-SSB, SSBP
Proteins	SSBP_HUMAN
NCBI Gene ID	6742
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SSBP1 has 9,278 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for SSBP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SSBP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SSBP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SSBP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SSBP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SSBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SSBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SSBP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SSBP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SSBP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SSBP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SSBP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SSBP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SSBP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SSBP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SSBP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SSBP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SSBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SSBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SSBP1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SSBP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SSBP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SSBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SSBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SSBP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SSBP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SSBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SSBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SSBP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SSBP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SSBP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SSBP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SSBP1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SSBP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SSBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SSBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SSBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SSBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SSBP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SSBP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SSBP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SSBP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.