SSBP3 Gene

Name	single stranded DNA binding protein 3
Description	Predicted to enable single-stranded DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSSBP3 is a conserved cofactor that plays a central role in assembling and stabilizing transcriptional complexes involving LIM-homeodomain proteins and the LIM domain–binding protein Ldb1 during animal development. In diverse species—from Drosophila to vertebrates—SSBP family members have been shown to interact with Ldb1, thereby enhancing transcriptional activation by partnering with LIM-HD proteins to regulate key developmental processes, such as axis induction and wing formation. This evolutionarily conserved function has been substantiated by studies demonstrating that SSBP proteins function as integral components of Ldb1-containing transcription complexes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nSSBP3 also plays a critical regulatory role in pancreatic islet cells, where it interacts with Ldb1 and the LIM-homeodomain transcription factor Isl1 to direct the expression of genes essential for β-cell function, including MafA and Glp1r. By potentiating the activity and stability of these transcription factor complexes, SSBP3 ensures the proper development and maturation of pancreatic islet cells, mirroring its developmental roles in other tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n \nIn addition to its role as a transcriptional cofactor, SSBP3 is subject to regulation via post-translational modifications that affect its localization and stability. Phosphorylation of specific N-terminal tyrosine residues promotes its translocation to the nucleus, thereby enhancing its transcriptional activity in the context of LIM-HD complexes. Moreover, SSBP3 interacts with regulatory factors such as SIVA1, which facilitate its ubiquitination and subsequent proteasomal degradation, suggesting that the precise control of SSBP3 levels is integral to the dynamic regulation of transcriptional complex assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lan Chen, Daniel Segal, Neil A Hukriede, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.212532399"}], "href": "https://doi.org/10.1073/pnas.212532399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12381786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12381786"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Liangtang Wu "}, {"type": "b", "children": [{"type": "t", "text": "Structure and functional characterization of single-strand DNA binding protein SSDP1: carboxyl-terminal of SSDP1 has transcription activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.11.098"}], "href": "https://doi.org/10.1016/j.bbrc.2005.11.098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16325762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16325762"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jamie R Galloway, Maigen Bethea, Yanping Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2015-1165"}], "href": "https://doi.org/10.1210/me.2015-1165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26495868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26495868"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Eliana Toren, Jessica D Kepple, Kristen V Coutinho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2023.101785"}], "href": "https://doi.org/10.1016/j.molmet.2023.101785"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37536498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37536498"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ipsita Dey-Guha, Nasir Malik, Renaud Lesourne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphorylation controls nuclear localization and transcriptional activity of Ssdp1 in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.21576"}], "href": "https://doi.org/10.1002/jcb.21576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18080319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18080319"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Z Yin, K Zhang, X Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[SIVA1 Regulates the Stability of Single-Stranded DNA-Binding Protein 3 Isoforms]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol (Mosk) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S0026898418050166"}], "href": "https://doi.org/10.1134/S0026898418050166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30363057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30363057"}]}]}]}
Synonyms	SSDP, CSDP, SSDP1
Proteins	SSBP3_HUMAN
NCBI Gene ID	23648
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SSBP3 has 7,863 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for SSBP3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SSBP3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SSBP3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SSBP3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SSBP3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SSBP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SSBP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SSBP3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SSBP3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SSBP3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SSBP3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SSBP3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SSBP3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SSBP3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SSBP3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SSBP3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SSBP3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SSBP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SSBP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SSBP3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SSBP3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SSBP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SSBP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SSBP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SSBP3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SSBP3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SSBP3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SSBP3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SSBP3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SSBP3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SSBP3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SSBP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SSBP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SSBP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SSBP3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SSBP3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SSBP3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SSBP3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SSBP3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SSBP3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SSBP3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SSBP3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.