{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nST8SIA1, which encodes the GD3 synthase enzyme, plays a central role in oncogenesis by catalyzing the biosynthesis of complex disialogangliosides that are key mediators of cancer stem cell properties, epithelial‐to‐mesenchymal transition, and metastatic progression. In breast cancer, for example, elevated ST8SIA1 drives GD2 production that marks cancer stem‐like cells and enables multiple EMT‐inducing pathways, while in glioblastoma and neuroblastoma its high expression underpins self‐renewal and tumorigenicity. In addition, aberrant ST8SIA1 expression in cancers such as colorectal, lung, and prostate malignancies promotes oncogenic signaling through pathways including c–Met, FAK–AKT–mTOR, and β–catenin, thereby enhancing cell proliferation, migration, invasion, chemoresistance, and ultimately poor clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic functions, ST8SIA1 is intricately involved in the regulation of cell signaling, apoptosis, and differentiation. In vascular smooth muscle and endothelial cells, overexpression of GD3 synthase modulates the cell cycle and promotes apoptosis by altering cyclin/CDK complexes and down‐regulating anti‐apoptotic proteins such as Bcl–2. Its own transcription is tightly controlled by various factors including NF–κB, FOXC2, SPI1, AREB6, Elk–1, and BACH1, and can be induced or repressed in response to stimuli such as Fas activation, curcumin via AMPK, tumor necrosis factor–α, and the cAMP signaling cascade. Moreover, subcellular localization regulated by interactions with molecular chaperones like calnexin, as well as post–translational modifications such as S–acylation that influence homodimer formation, further determine its pro–apoptotic and functional outcomes. These diverse regulatory mechanisms have been elucidated through promoter analyses, mutational studies, and RNA interference approaches."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nST8SIA1’s influence also extends to broader physiological and pathophysiological processes. Its dysregulated expression has been linked not only to malignant progression but also to altered tissue remodeling, immune responses, and neuroplasticity. Genetic association studies have implicated ST8SIA1 in conditions such as periodontitis, multiple sclerosis, and thyroid–associated ophthalmopathy, while in melanocytes and gastric cancer cells its regulation by extracellular cytokines and long non–coding RNAs contributes to changes in ganglioside profiles that may favor disease progression. Furthermore, innovative genome–editing and epigenetic studies have revealed that disruption or de–repression of ST8SIA1 can impact cell–matrix adhesion and integrin signaling, thereby potentially compromising barrier integrity and influencing pathologies beyond cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "T R Sarkar, V L Battula, S J Werden, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "GD₃ synthase expression enhances proliferation and tumor growth of MDA-MB-231 breast cancer cells through c-Met activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-10-0302"}], "href": "https://doi.org/10.1158/1541-7786.MCR-10-0302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20889649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20889649"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Aurélie Cazet, Sophie Groux-Degroote, Béatrice Teylaert, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M313462200"}], "href": "https://doi.org/10.1074/jbc.M313462200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15175338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15175338"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nam-Young Kang, Cheorl-Ho Kim, Kyoung-Sook Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycobiology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/glycob/cwj087"}], "href": "https://doi.org/10.1093/glycob/cwj087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16481330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16481330"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Keiko Furukawa, Masato Horie, Kei-ichi Okutomi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0167-4781(03)00076-9"}], "href": "https://doi.org/10.1016/s0167-4781(03"}, {"type": "t", "text": "00076-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12818424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12818424"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Miri Lee, Kyoung-Sook Kim, Abekura Fukushi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional Activation of Human GD3 Synthase (hST8Sia I) Gene in Curcumin-Induced Autophagy in A549 Human Lung Carcinoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms19071943"}], "href": "https://doi.org/10.3390/ijms19071943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30004453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30004453"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Agata Steenackers, Jorick Vanbeselaere, Aurélie Cazet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accumulation of unusual gangliosides G(Q3) and G(P3) in breast cancer cells expressing the G(D3) synthase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Molecules (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/molecules17089559"}], "href": "https://doi.org/10.3390/molecules17089559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22885356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22885356"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hyun-Mi Dae, Haw-Young Kwon, Nam-Young Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isolation and functional analysis of the human glioblastoma-specific promoter region of the human GD3 synthase (hST8Sia I) gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmp007"}], "href": "https://doi.org/10.1093/abbs/gmp007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19280063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19280063"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Italo Tempera, Barbara Buchetti, Emanuela Lococo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GD3 nuclear localization after apoptosis induction in HUT-78 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.12.196"}], "href": "https://doi.org/10.1016/j.bbrc.2007.12.196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18261989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18261989"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ki-Tae Ha, Young-Choon Lee, Cheorl-Ho Kim "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2004.05.020"}], "href": "https://doi.org/10.1016/j.febslet.2004.05.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15196944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15196944"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Sung-Koo Kang, Yong-Sam Kim, Yun-Jeong Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.200800153"}], "href": "https://doi.org/10.1002/pmic.200800153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18690648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18690648"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Sabrina Chumpen Ramirez, Fernando M Ruggiero, Jose Luis Daniotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ganglioside glycosyltransferases are S-acylated at conserved cysteine residues involved in homodimerisation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20170124"}], "href": "https://doi.org/10.1042/BCJ20170124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28698248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28698248"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Rika Takeuchi, Mariko Kambe, Maiko Miyata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNFα-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-51333-3"}], "href": "https://doi.org/10.1038/s41598-019-51333-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31611597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31611597"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yihua Gu, Robert K Yu "}, {"type": "b", "children": [{"type": "t", "text": "Identification and analysis of novel functional sites in human GD3-synthase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.03.029"}], "href": "https://doi.org/10.1016/j.bbrc.2008.03.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18348864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18348864"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "S Freitag-Wolf, M Munz, R Wiehe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smoking Modifies the Genetic Risk for Early-Onset Periodontitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dent Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0022034519875443"}], "href": "https://doi.org/10.1177/0022034519875443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31537151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31537151"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Maiko Miyata, Masatoshi Ichihara, Orie Tajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor α and interleukin 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.02.038"}], "href": "https://doi.org/10.1016/j.bbrc.2014.02.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24548412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24548412"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Fang Zuo, Yong Zhang, Jianting Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2001168"}], "href": "https://doi.org/10.1080/21655979.2021.2001168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34738863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34738863"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Guichao Zeng, Luoyi Gao, Keiji Suetake, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0304-3835(01)00817-5"}], "href": "https://doi.org/10.1016/s0304-3835(01"}, {"type": "t", "text": "00817-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11849746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11849746"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Seema Husain, Cagri Yildirim-Toruner, Justin P Rubio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants of ST8SIA1 are associated with risk of developing multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0002653"}], "href": "https://doi.org/10.1371/journal.pone.0002653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18612409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18612409"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Laura Mandelli, Roberta Emiliani, Stefano Porcelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genes involved in neuroplasticity and stressful life events act on the short-term response to antidepressant treatment: a complex interplay between genetics and environment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Psychopharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hup.2411"}], "href": "https://doi.org/10.1002/hup.2411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25163442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25163442"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Hyo Jin Park, Ju Hee Kim, Jin Sook Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Functional Characterization of ST3GAL5 and ST8SIA1 Variants in Patients with Thyroid-Associated Ophthalmopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yonsei Med J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3349/ymj.2017.58.6.1160"}], "href": "https://doi.org/10.3349/ymj.2017.58.6.1160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29047240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29047240"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "A Chopra, R Mueller, J Weiner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACH1 Binding Links the Genetic Risk for Severe Periodontitis with "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ST8SIA1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dent Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/00220345211017510"}], "href": "https://doi.org/10.1177/00220345211017510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34160287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34160287"}]}]}]}