STAU2 Gene

Name	staufen double-stranded RNA binding protein 2
Description	Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTAU2 is a double‐stranded RNA‐binding protein that plays a pivotal role in the post‐transcriptional regulation of mRNAs. In neurons, it is highly expressed and localized to the somatodendritic compartment, where multiple splice isoforms of STAU2 are aligned along microtubules and found in diverse ribonucleoprotein (RNP) complexes, some of which associate with ribosomes to potentially modulate translation. In human cells, comparative genome‐wide analyses have revealed that STAU2, although sharing some features with its paralogue STAU1, occupies distinct mRNP complexes and targets unique subsets of transcripts. Moreover, STAU2 contributes to STAU1-mediated mRNA decay (SMD) by interacting with UPF1, thereby promoting its helicase activity and efficient decay of mRNAs containing STAU1-binding sites."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in mRNA transport and decay, STAU2 functions in synaptic plasticity and cell stress responses. Within hippocampal neurons, while STAU1 is essential for protein synthesis-dependent long-term potentiation (L-LTP), STAU2 is selectively required for mGluR-dependent long-term depression (mGluR-LTD) by regulating the dendritic localization and translation of specific mRNAs such as Map1b. Outside the nervous system, STAU2 steady-state levels are tightly regulated during cell cycle progression and are notably downregulated upon treatment with DNA-damaging agents; this effect, mediated via the ATR pathway and displacement of the E2F1 transcription factor, is associated with enhanced DNA damage and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its endogenous regulatory roles, STAU2 has been implicated in viral replication and neuroendocrine signaling. In the context of HIV-1 infection, STAU2 interacts with components of the viral machinery, including Gag, to become incorporated into budding virions, thereby enhancing viral infectivity. Furthermore, the stability of STAU2 in the hypothalamus is modulated by the ubiquitin E3 ligase RNF216, an interaction that impacts the expression of key RNAs involved in GnRH signaling pathways and may contribute to the pathogenesis of idiopathic hypogonadotropic hypogonadism (IHH)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Thomas F Duchaîne, Indradeo Hemraj, Luc Furic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.115.16.3285"}], "href": "https://doi.org/10.1242/jcs.115.16.3285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12140260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12140260"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Luc Furic, Marjolaine Maher-Laporte, Luc DesGroseillers "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.720308"}], "href": "https://doi.org/10.1261/rna.720308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18094122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18094122"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eonyoung Park, Michael L Gleghorn, Lynne E Maquat "}, {"type": "b", "children": [{"type": "t", "text": "Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1213508110"}], "href": "https://doi.org/10.1073/pnas.1213508110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23263869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23263869"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Geneviève Lebeau, Linda C Miller, Maylis Tartas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Learn Mem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/lm.2100611"}], "href": "https://doi.org/10.1101/lm.2100611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21508097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21508097"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xin Zhang, Véronique Trépanier, Remy Beaujois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkw057"}], "href": "https://doi.org/10.1093/nar/gkw057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26843428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26843428"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lionel Condé, Yulemi Gonzalez Quesada, Florence Bonnet-Magnaval, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12860-021-00352-y"}], "href": "https://doi.org/10.1186/s12860-021-00352-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33663378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33663378"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yao Wang, Wen Zhang, Yu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.767630"}], "href": "https://doi.org/10.3389/fimmu.2022.767630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35392093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35392093"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Han Yang, Yong Zhu, Xin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF216 affects the stability of STAU2 in the hypothalamus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Growth Differ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/dgd.12877"}], "href": "https://doi.org/10.1111/dgd.12877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37439148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37439148"}]}]}]}
Synonyms	39K3, 39K2
Proteins	STAU2_HUMAN
NCBI Gene ID	27067
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STAU2 has 6,970 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for STAU2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STAU2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STAU2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STAU2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of STAU2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STAU2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STAU2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STAU2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of STAU2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STAU2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STAU2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of STAU2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STAU2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STAU2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with STAU2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with STAU2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STAU2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STAU2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STAU2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of STAU2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of STAU2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STAU2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STAU2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing STAU2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing STAU2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STAU2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STAU2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STAU2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STAU2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with STAU2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with STAU2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with STAU2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STAU2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with STAU2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STAU2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STAU2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STAU2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STAU2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STAU2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of STAU2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing STAU2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with STAU2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.