Name | stanniocalcin 1 |
Description | This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStanniocalcin‐1 (STC1) is a multifunctional secreted glycoprotein originally discovered in bony fish that has evolved in mammals into a pleiotropic regulator of mineral homeostasis, cellular metabolism, and growth. In vivo studies show that transgenic overexpression of human STC1 in mice alters phosphate reabsorption, diminishes postnatal growth, and disrupts reproductive performance, while biochemical analyses have revealed that STC1 localizes predominantly to mitochondria—where it modulates electron transfer—and is expressed in mature adipocytes and growth plate chondrocytes, thereby influencing skeletal development and cell survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, STC1 expression is frequently up‐regulated under hypoxic conditions via HIF‑1–dependent mechanisms and further modulated by key transcriptional factors such as p53 and NF‑κB, promoting tumor cell survival, invasion, and metastasis. Elevated STC1 levels have been correlated with aggressive phenotypes across a broad range of malignancies—including ovarian, gastric, esophageal, colorectal, renal, and breast cancers—as well as gliomas and even acute leukemia—and contribute to autocrine and paracrine signaling loops that enhance angiogenesis (through interference with growth factor pathways such as VEGF and HGF), stimulate protease activity (for example by inhibiting pregnancy‐associated plasma protein‑A), and foster stem‐like traits that may underlie tumor dormancy and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor progression, STC1 serves as a critical modulator in vascular, inflammatory, and organ‐protective responses. Experimental models have shown that STC1 can attenuate inflammatory cell transmigration across endothelial barriers and promote neuroprotection following hypoxic preconditioning, while its actions in endothelial cells—mediated via interactions with VEGF and FGF‑2 signaling—contribute to angiogenic sprouting and stabilization of blood vessels. Moreover, STC1 has been demonstrated to reduce apoptosis and oxidative stress in models of optic neuropathy, diabetic kidney disease, and in the hematopoietic niche of acute myeloid leukemia, underscoring its potential as a therapeutic target to ameliorate tissue injury and aberrant remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Robin Varghese, Anthony D Gagliardi, Peter E Bialek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endo.143.3.8671"}], "href": "https://doi.org/10.1210/endo.143.3.8671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11861508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11861508"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christopher R McCudden, Kathi A James, Craig Hasilo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205954200"}], "href": "https://doi.org/10.1074/jbc.M205954200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12223480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12223480"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David Sheikh-Hamad, Roger Bick, Gang-Yi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.01071.2002"}], "href": "https://doi.org/10.1152/ajpheart.01071.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12663264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12663264"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ching-Wei Luo, Kazuhiro Kawamura, Cynthia Klein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2004-0066"}], "href": "https://doi.org/10.1210/me.2004-0066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15131261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15131261"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yasuo Tohmiya, Yoshio Koide, Shinichi Fujimaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1 as a novel marker to detect minimal residual disease of human leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tohoku J Exp Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1620/tjem.204.125"}], "href": "https://doi.org/10.1620/tjem.204.125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15383693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15383693"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shufang Wu, Yuji Yoshiko, Francesco De Luca "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M506667200"}], "href": "https://doi.org/10.1074/jbc.M506667200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16377640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16377640"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jennifer Johnston, Yudith Ramos-Valdes, Lee-Anne Stanton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transgenic Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11248-010-9376-7"}], "href": "https://doi.org/10.1007/s11248-010-9376-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20174869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20174869"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ho Y Yeung, Keng P Lai, Hoi Y Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2005-0365"}], "href": "https://doi.org/10.1210/en.2005-0365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16109785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16109785"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Keng P Lai, Alice Y S Law, Ho Y Yeung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of stanniocalcin-1 expression in apoptotic human nasopharyngeal cancer cells by p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.03.074"}], "href": "https://doi.org/10.1016/j.bbrc.2007.03.074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17395153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17395153"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "David I R Holmes, Ian C Zachary "}, {"type": "b", "children": [{"type": "t", "text": "Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2007.11.009"}], "href": "https://doi.org/10.1016/j.cellsig.2007.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18164591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18164591"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kristiina Joensuu, Päivi Heikkilä, Leif C Andersson "}, {"type": "b", "children": [{"type": "t", "text": "Tumor dormancy: elevated expression of stanniocalcins in late relapsing breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2008.02.022"}], "href": "https://doi.org/10.1016/j.canlet.2008.02.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18355956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18355956"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Gregory J Block, Shinya Ohkouchi, France Fung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.20080742"}], "href": "https://doi.org/10.1002/stem.20080742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19267325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19267325"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "A Y S Law, L Y Ching, K P Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2009.07.007"}], "href": "https://doi.org/10.1016/j.mce.2009.07.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19628018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19628018"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Guangzhi Liu, Gong Yang, Bin Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin 1 and ovarian tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djq127"}], "href": "https://doi.org/10.1093/jnci/djq127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20484106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20484106"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shuzo Tamura, Takashi Oshima, Kazue Yoshihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of STC1 gene expression in patients with colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21273618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21273618"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ling-fang He, Ting-ting Wang, Qian-ying Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biomed Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1423-0127-18-39"}], "href": "https://doi.org/10.1186/1423-0127-18-39"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21672207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21672207"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mitsuhiro Shirakawa, Yoshiyuki Fujiwara, Yurika Sugita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2011.1607"}], "href": "https://doi.org/10.3892/or.2011.1607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22200953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22200953"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Cristina Peña, María Virtudes Céspedes, Maja Bradic Lindh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-1875"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-1875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23243022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23243022"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jong Hyuk Yoon, Jaeyoon Kim, Kyung Lock Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic analysis of hypoxia-induced U373MG glioma secretome reveals novel hypoxia-dependent migration factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.201300554"}], "href": "https://doi.org/10.1002/pmic.201300554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24729417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24729417"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Han Zhou, Ying-Ying Li, Wei-Qiang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of stanniocalcin-1 and stanniocalcin-2 in laryngeal squamous cell carcinoma and correlations with clinical and pathological parameters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0095466"}], "href": "https://doi.org/10.1371/journal.pone.0095466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24743310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24743310"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Andy C-M Chang, Judy Doherty, Lily I Huschtscha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STC1 expression is associated with tumor growth and metastasis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-014-9687-9"}], "href": "https://doi.org/10.1007/s10585-014-9687-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25391215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25391215"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xin Ma, Liangyou Gu, Hongzhao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-015-0421-4"}], "href": "https://doi.org/10.1186/s12967-015-0421-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25740019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25740019"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jingyuan Su, Bingyu Guo, Tingting Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1, a new biomarker of glioma progression, is associated with prognosis of patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3319-0"}], "href": "https://doi.org/10.1007/s13277-015-3319-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25783529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25783529"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Dong Dai, Qi Wang, Xiaofeng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4358"}], "href": "https://doi.org/10.3892/or.2015.4358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26531219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26531219"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Malene R Jepsen, Søren Kløverpris, Jane A Bøtkjær, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dew013"}], "href": "https://doi.org/10.1093/humrep/dew013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26874357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26874357"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jeonghun Han, Myeongjin Jeon, Incheol Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated STC‑1 augments the invasiveness of triple‑negative breast cancer cells through activation of the JNK/c‑Jun signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4977"}], "href": "https://doi.org/10.3892/or.2016.4977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27459971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27459971"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Kristy Kwan-Shuen Chan, Carmen Oi-Ning Leung, Carmen Chak-Lui Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.06.034"}], "href": "https://doi.org/10.1016/j.canlet.2017.06.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28688970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28688970"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yong Li, Zhi-Cheng He, Xiao-Ning Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding and activating NOTCH1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.11.033"}], "href": "https://doi.org/10.1016/j.canlet.2017.11.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29196129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29196129"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Sheng Huang, Yayun Chi, Yi Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.22523"}], "href": "https://doi.org/10.7150/thno.22523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29721098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29721098"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Feikai Lin, Xiaoduan Li, Xinjing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-022-02315-3"}], "href": "https://doi.org/10.1186/s13046-022-02315-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35392966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35392966"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Arup Chakraborty, Heddwen Brooks, Ping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00219.2006"}], "href": "https://doi.org/10.1152/ajprenal.00219.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17032941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17032941"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Johan A Westberg, Martina Serlachius, Petri Lankila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.STR.0000258113.67252.fa"}], "href": "https://doi.org/10.1161/01.STR.0000258113.67252.fa"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17272771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17272771"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Changyi Chen, Md Saha Jamaluddin, Shaoyu Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.108.163667"}], "href": "https://doi.org/10.1161/ATVBAHA.108.163667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18309109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18309109"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Alice Y S Law, Chris K C Wong "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2013.04.024"}], "href": "https://doi.org/10.1016/j.mce.2013.04.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23664860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23664860"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Sang Jin Kim, Jung Hwa Ko, Ji-Hyun Yun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stanniocalcin-1 protects retinal ganglion cells by inhibiting apoptosis and oxidative damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0063749"}], "href": "https://doi.org/10.1371/journal.pone.0063749"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23667669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23667669"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Manabu Ono, Shinya Ohkouchi, Masahiko Kanehira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mt.2014.217"}], "href": "https://doi.org/10.1038/mt.2014.217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25373521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25373521"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Zhiwen Liu, Hong Liu, Li Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STC-1 ameliorates renal injury in diabetic nephropathy by inhibiting the expression of BNIP3 through the AMPK/SIRT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41374-018-0176-7"}], "href": "https://doi.org/10.1038/s41374-018-0176-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30683904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30683904"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Alexander Waclawiczek, Ashley Hamilton, Kevin Rouault-Pierre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI133187"}], "href": "https://doi.org/10.1172/JCI133187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32364536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32364536"}]}]}]}
|
Synonyms | STC |
Proteins | STC1_HUMAN |
NCBI Gene ID | 6781 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
STC1 has 11,255 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 106 datasets.
Click the + buttons to view associations for STC1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of STC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of STC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of STC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of STC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of STC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of STC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of STC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of STC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of STC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with STC1 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with STC1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of STC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of STC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of STC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of STC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing STC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing STC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing STC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with STC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with STC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of STC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with STC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with STC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with STC1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with STC1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by STC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with STC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with STC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with STC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with STC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with STC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at STC1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of STC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of STC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing STC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with STC1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with STC1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of STC1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with STC1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing STC1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of STC1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of STC1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of STC1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of STC1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of STC1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of STC1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding STC1 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving STC1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving STC1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving STC1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing STC1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing STC1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing STC1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by STC1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of STC1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of STC1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of STC1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of STC1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
GWASdb SNP-Disease Associations | diseases associated with STC1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with STC1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of STC1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of STC1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of STC1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of STC1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of STC1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for STC1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuBMAP ASCT+B Annotations | cell types associated with STC1 gene from the HuBMAP ASCT+B dataset. | |
HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with STC1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
HuBMAP Azimuth Cell Type Annotations | cell types associated with STC1 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with STC1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for STC1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of STC1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of STC1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with STC1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of STC1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of STC1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of STC1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of STC1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing STC1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain STC1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by STC1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of STC1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by STC1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of STC1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of STC1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing STC1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of STC1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of STC1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving STC1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving STC1 protein from the Wikipathways PFOCR 2024 dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of STC1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at STC1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of STC1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of STC1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with STC1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of STC1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of STC1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of STC1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of STC1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of STC1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of STC1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of STC1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of STC1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with STC1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with STC1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2024 | pathways involving STC1 protein from the WikiPathways Pathways 2024 dataset. | |