{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTEAP1 is a membrane‐bound cell surface protein that is widely overexpressed in a variety of human malignancies—including prostate, breast, Ewing, ovarian, and other cancers—and is detectable not only in tumor tissues but also in circulation (for example, in serum and extracellular vesicles). Its abundant and tumor‐selective expression has enabled its use as a diagnostic biomarker and has provided the rationale for immunotherapeutic strategies. Peptide‐based approaches have been developed to stimulate cytotoxic T lymphocyte responses, and targeted microbubble imaging has been explored to improve tumor detection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular and cellular level, STEAP1 promotes oncogenic processes through a combination of catalytic and signaling activities. Biochemical and biophysical analyses have revealed that STEAP1 assembles as oligomers and binds heme prosthetic groups, conferring ferric reductase and superoxide‐synthase activities that modulate iron and copper reduction as well as cellular oxidative stress. These redox reactions are linked to the regulation of critical downstream pathways—including JAK2/STAT3, AKT/FoxO1, and NRF2‐dependent antioxidant responses—that drive cell proliferation, migration, invasion, and epithelial–mesenchymal transition. Consistent with these functions, genetic or pharmacologic inhibition of STEAP1 reduces tumor cell viability, promotes apoptotic pathways, and impairs metastatic potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSTEAP1 expression is governed by a complex network of hormonal and transcriptional regulators that vary with tissue context and disease state. In hormone‐responsive cancers, its expression is modulated by androgens and estrogens—exhibiting either up‐regulation or down‐regulation depending on the cellular milieu—with downstream effects on tumor progression. In Ewing sarcoma, oncogenic fusion proteins and transcription factors such as EWS/FLI1 and NKX2.2 cooperate to drive STEAP1 expression, while anti‐androgen treatments in prostate cancer have been shown to differentially affect its levels. Such multifaceted regulation not only impacts tumor biology and the epithelial–mesenchymal transition but also supports the development of immunotherapeutic approaches based on STEAP1–derived peptides and combined treatment strategies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David A Rodeberg, Rebecca A Nuss, Sherine F Elsawa, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16038"}], "href": "https://doi.org/10.1111/jcmm.16038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33128353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33128353"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Xuan Zou, Chang Liu, Zuotian Huang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2023.119522"}], "href": "https://doi.org/10.1016/j.bbamcr.2023.119522"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37315586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37315586"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Cláudio J B Maia, Sílvia Socorro, Fernando Schmitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP1 is over-expressed in breast cancer and down-regulated by 17beta-estradiol in MCF-7 cells and in the rat mammary gland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-008-9113-7"}], "href": "https://doi.org/10.1007/s12020-008-9113-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18958632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18958632"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Inês M Gomes, Cecília R Santos, Sílvia Socorro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.22601"}], "href": "https://doi.org/10.1002/pros.22601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23060075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23060075"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Michael G Doran, Philip A Watson, Sarah M Cheal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annotating STEAP1 regulation in prostate cancer with 89Zr immuno-PET."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nucl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2967/jnumed.114.145185"}], "href": "https://doi.org/10.2967/jnumed.114.145185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25453051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25453051"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jie Xie, Yan Yang, Jiali Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP1 Inhibits Breast Cancer Metastasis and Is Associated With Epithelial-Mesenchymal Transition Procession."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Breast Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clbc.2018.08.010"}], "href": "https://doi.org/10.1016/j.clbc.2018.08.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30253922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30253922"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Fatu Badiane Markey, Brigette Romero, Vijay Parashar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing's Sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10061300"}], "href": "https://doi.org/10.3390/cells10061300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34073779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34073779"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Sandra M Rocha, Daniel Nascimento, Ana Margarida Cardoso, et al. 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