{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTEAP4, also known as STAMP2 or TIARP, is a multifunctional transmembrane metalloreductase that plays a central role in maintaining metabolic homeostasis. Through its enzymatic activity, STEAP4 facilitates the reduction of metal ions such as Fe³⁺ and Cu²⁺ via an intrinsic electron transfer chain that uses essential cofactors and a heme group. In adipocytes and related mesenchymal cells, STEAP4 is upregulated during differentiation and has been shown to enhance insulin‐stimulated glucose uptake by promoting GLUT4 translocation via Akt phosphorylation. Moreover, studies in both human and murine models indicate that STEAP4 modulates lipid storage, adipogenesis, and overall energy expenditure—findings that underscore its importance in obesity and type 2 diabetes. Its function in regulating metal ion homeostasis further supports its role as a protective factor against metabolic stress and inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n \n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in metabolism, STEAP4 is a critical mediator of inflammatory signaling. In adipocytes and synovial cells, inflammatory cytokines such as interleukin‑1β and TNF‑α robustly induce STEAP4 expression, suggesting that it functions as an adaptive response to inflammatory stress. Its regulatory influence extends to modulating NF‑κB and STAT‑3 pathways, thereby affecting the synthesis of key cytokines like IL‑6 and TNF‑α. Furthermore, studies in rheumatoid arthritis patients reveal that both the full‐length protein and alternatively spliced variants of STEAP4 may differentially regulate inflammatory responses and cell proliferation, hinting at a potential feedback role in chronic inflammatory diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": "\n \n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond metabolic and inflammatory regulation, STEAP4 exerts notable functions in the control of cellular proliferation and oncogenesis. In prostate cancer cells and other malignancies, STEAP4 expression is often dysregulated and appears to influence anchorage‐independent cell growth, focal adhesion dynamics via its interaction with FAK, and redox balance. Its emerging role in various cancers—including breast cancer, glioma, and benign prostatic hyperplasia—suggests that STEAP4 may serve as both a prognostic biomarker and a potential therapeutic target in tumors where metabolic and proliferative signaling converge."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "24"}]}, {"type": "t", "text": "\n \n"}, {"type": "p", "children": [{"type": "t", "text": "\nA number of genetic association studies have explored variations in the STEAP4 gene and their links with metabolic syndrome, obesity, insulin resistance, and hypertension in diverse populations. Several independent investigations have reported significant correlations between STEAP4 single nucleotide polymorphisms and clinical parameters including body mass index, lipid profiles, blood pressure, and glycemic control. These findings underscore the potential of STEAP4 both as a biomarker for susceptibility to metabolic disorders and as a candidate for targeted pharmacological intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "39"}]}, {"type": "t", "text": "\n \n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, STEAP4 has been implicated in hepatic and cardiovascular protection. In the context of nonalcoholic fatty liver disease, for example, upregulation of STEAP4 driven by agents such as FGF21 or AMPK activators has been shown to ameliorate hepatic steatosis and iron overload, thereby improving insulin sensitivity. Similarly, in models of myocardial ischemia/reperfusion injury, STEAP4 modulates inflammatory cell infiltration and fibroblast activation to preserve cardiac structure and function. These observations highlight the broad therapeutic potential of targeting STEAP4 in disorders characterized by metabolic dysregulation, oxidative stress, and tissue remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "40"}]}, {"type": "t", "text": ""}]}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C J Narvaez, K M Simmons, J Brunton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24371"}], "href": "https://doi.org/10.1002/jcp.24371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23553608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23553608"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rachel T Scarl, C Martin Lawrence, Hannah M Gordon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JOE-16-0594"}], "href": "https://doi.org/10.1530/JOE-16-0594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28576871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28576871"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaohui Chen, Chun Zhu, Chenbo Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm_00000353"}], "href": "https://doi.org/10.3892/ijmm_00000353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20127040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20127040"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rui Cheng, Jie Qiu, Xiao-Yu Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2011.443"}], "href": "https://doi.org/10.3892/mmr.2011.443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21468601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21468601"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hye Young Kim, Hyun Kook Cho, Seong Keun Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3858/emm.2012.44.10.071"}], "href": "https://doi.org/10.3858/emm.2012.44.10.071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23095254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23095254"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wout Oosterheert, Laura S van Bezouwen, Remco N P Rodenburg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-06817-7"}], "href": "https://doi.org/10.1038/s41467-018-06817-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30337524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30337524"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yoo Jin Oh, Hye Young Kim, Mi Hwa Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cilostazol Improves HFD-Induced Hepatic Steatosis by Upregulating Hepatic STAMP2 Expression through AMPK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.118.113217"}], "href": "https://doi.org/10.1124/mol.118.113217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30366981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30366981"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hye Young Kim, Woo Young Kwon, Joon Beom Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202000790R"}], "href": "https://doi.org/10.1096/fj.202000790R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32721044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32721044"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hannah M Gordon, Neil Majithia, Patrick E MacDonald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-017-1297-2"}], "href": "https://doi.org/10.1007/s12020-017-1297-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28405880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28405880"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Peter Arner, Britta M Stenson, Elisabeth Dungner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2008-0206"}], "href": "https://doi.org/10.1210/jc.2008-0206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18381574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18381574"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Nutr (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00394-012-0464-8"}], "href": "https://doi.org/10.1007/s00394-012-0464-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23179203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23179203"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Susan Kralisch, Grit Sommer, Sebastian Weise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2009.03.015"}], "href": "https://doi.org/10.1016/j.febslet.2009.03.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19289123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19289123"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yoko Tanaka, Isao Matsumoto, Keiichi Iwanami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Rheumatol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10165-011-0475-y"}], "href": "https://doi.org/10.1007/s10165-011-0475-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21633911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21633911"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "H Ebe, I Matsumoto, H Kawaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and functional significance of STEAP4-splice variant in CD14"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " monocytes in patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cei.13076"}], "href": "https://doi.org/10.1111/cei.13076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29080328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29080328"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mehreen Batool, Eva M Berghausen, Mario Zierden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Basic Res Cardiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00395-020-00826-8"}], "href": "https://doi.org/10.1007/s00395-020-00826-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33188479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33188479"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Martin Mollenhauer, Senai Bokredenghel, Simon Geißen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.701721"}], "href": "https://doi.org/10.3389/fimmu.2021.701721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34691017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34691017"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "José María Moreno-Navarrete, Francisco Ortega, Marta Serrano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased STAMP2 expression in association with visceral adipose tissue dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2011-0310"}], "href": "https://doi.org/10.1210/jc.2011-0310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21849520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21849520"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yang Jin, Ling Wang, Su Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAMP2 increases oxidative stress and is critical for prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201404181"}], "href": "https://doi.org/10.15252/emmm.201404181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25680860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25680860"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Takahiko Tamura, Joe Chiba "}, {"type": "b", "children": [{"type": "t", "text": "STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm_00000270"}], "href": "https://doi.org/10.3892/ijmm_00000270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19787193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19787193"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Seong Keun Yoo, JaeHun Cheong, Hye Young Kim "}, {"type": "b", "children": [{"type": "t", "text": "STAMPing into Mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.8456"}], "href": "https://doi.org/10.7150/ijbs.8456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24643198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24643198"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hua-Tao Wu, Wen-Jia Chen, Ya Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/9578484"}], "href": "https://doi.org/10.1155/2020/9578484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32802887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32802887"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zijun Zhao, Zairan Wang, Zihan Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2021.108183"}], "href": "https://doi.org/10.1016/j.intimp.2021.108183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34649092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34649092"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jiang Liu, Wei Zhou, Liang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2023.110933"}], "href": "https://doi.org/10.1016/j.cellsig.2023.110933"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37866665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37866665"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yijie Tang, Yingda Wang, Xiaodong Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2022.153870"}], "href": "https://doi.org/10.1016/j.prp.2022.153870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35390632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35390632"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Teresia Wangensteen, Hanne Akselsen, Jostein Holmen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Obesity (Silver Spring) (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/oby.2010.219"}], "href": "https://doi.org/10.1038/oby.2010.219"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20885390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20885390"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Y Tanaka, I Matsumoto, K Iwanami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Six-transmembrane epithelial antigen of prostate 4 (STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Rheumatol (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22244520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22244520"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Aurélie Miot, Suliya Maimaitiming, Nathalie Emery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variability at the six transmembrane protein of prostate 2 locus and the metabolic syndrome: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2010-0026"}], "href": "https://doi.org/10.1210/jc.2010-0026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20382686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20382686"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Li Nanfang, Guo Yanying, Wang Hongmei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Med Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.arcmed.2010.08.006"}], "href": "https://doi.org/10.1016/j.arcmed.2010.08.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21044749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21044749"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Fusun Ozmen, M Mahir Ozmen, Sibel Gelecek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STEAP4 and HIF-1α gene expressions in visceral and subcutaneous adipose tissue of the morbidly obese patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2016.03.008"}], "href": "https://doi.org/10.1016/j.molimm.2016.03.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27058639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27058639"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yue Qi, Yaqin Yu, Yanhua Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Variants in Six-Transmembrane Epithelial Antigen of Prostate 4 Increase Risk of Developing Metabolic Syndrome in a Han Chinese Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2015.0104"}], "href": "https://doi.org/10.1089/gtmb.2015.0104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26510124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26510124"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "H M Xu, Y Z Cui, W G Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and clinical significance of obesity-associated gene STEAP4 in obese children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr.15048705"}], "href": "https://doi.org/10.4238/gmr.15048705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27808366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27808366"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Yan-ying Guo, Nan-fang Li, Ling Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin Med J (Engl) (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21933608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21933608"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Yan-ying Guo, Nan-fang Li, Chang-min Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2011.01.018"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2011.01.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21287516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21287516"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yan-ying Guo, Ling Zhou, Xiao-guang Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Association of STEAP4 genetic polymorphisms with insulin resistance in Uygur Chinese general population]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3881/j.issn.1000-503X.2011.03.018"}], "href": "https://doi.org/10.3881/j.issn.1000-503X.2011.03.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21718614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21718614"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Wenchao Zhang, Mengxiong Tang, Ming Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the six transmembrane protein of prostate 2 gene polymorphisms with metabolic syndrome in Han Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Metab Syndr (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dsx.2013.06.011"}], "href": "https://doi.org/10.1016/j.dsx.2013.06.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23953178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23953178"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "L Y Gui, Y L Hu, Z L Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and clinical significance of the obesity-related gene TNFAIP9 in obese children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr.15037995"}], "href": "https://doi.org/10.4238/gmr.15037995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27706555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27706555"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Rui-mei Han, Nan-fang Li, Zhi-tao Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphism of six transmembrane protein of prostate 2 associated with diabetes mellitus in Xinjiang Uygur population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3881/j.issn.1000-503X.2012.05.013"}], "href": "https://doi.org/10.3881/j.issn.1000-503X.2012.05.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23134829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23134829"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Chun-Mei Zhang, Xia Chi, Bin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Pharmacol Sin (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1745-7254.2008.00793.x"}], "href": "https://doi.org/10.1111/j.1745-7254.2008.00793.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18430367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18430367"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Yun-wei Bi, Chang-min Wang, Zhi-tao Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2011.01.015"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2011.01.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21287513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21287513"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Lin Zhu, Bin Li, Dongqin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2022.120438"}], "href": "https://doi.org/10.1016/j.lfs.2022.120438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35227772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35227772"}]}]}]}