STIM1 Gene

HGNC Family	Sterile alpha motif (SAM) domain containing (SAMD)
Name	stromal interaction molecule 1
Description	This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTIM1 functions as an endoplasmic reticulum (ER) Ca²⁺ sensor that detects decreases in luminal Ca²⁺ levels and, in response, undergoes rapid conformational changes and oligomerization. This event triggers its translocation from a diffuse ER distribution to discrete puncta positioned at ER–plasma membrane junctions. There, STIM1 “activates” store‐operated Ca²⁺ entry (SOCE) by physically coupling to, and gating, Ca²⁺ channels such as Orai1. These studies demonstrate that the EF‐hand and sterile alpha–motif (SAM) domains mediate calcium binding and oligomerization, thereby linking ER Ca²⁺ store depletion to channel activation through localized clustering in strategically apposed membrane regions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nElucidation of STIM1’s domains has revealed that specific segments—most notably its minimal Ca²⁺ release-activated Ca²⁺ (CRAC) activation region (often termed SOAR) and coiled–coil domains—mediate direct interactions with Orai1’s cytosolic regions, ultimately triggering channel opening. Mutational analyses have shown that disruption or constitutive activation of these regions can dramatically alter Ca²⁺ influx, leading either to a loss of SOCE or to its aberrant, store–independent activation. These molecular insights highlight that, beyond mere clustering, defined electrostatic and structural interactions between STIM1 and its channel partners (including, in some contexts, TRPC proteins) underlie fine regulation of channel gating, ion selectivity, and the kinetics of Ca²⁺ entry."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in mediating SOCE, STIM1 is now appreciated as a multifunctional regulator whose dysregulation can impact diverse physiological processes. Its ability to modulate Ca²⁺ influx is critical for T cell activation, muscle function, and even cancer cell migration and metastasis. Moreover, emerging evidence points to roles for STIM1 in the remodeling of ER–plasma membrane junctions, in the suppression of voltage–gated Ca²⁺ channels, and in interfacing with innate immune mediators such as STING. Such findings underscore the clinical relevance of STIM1, as mutations in its functional domains are linked to immunodeficiency, myopathy, and bleeding disorders, highlighting the centrality of controlled Ca²⁺ homeostasis in human health."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "35", "end_ref": "44"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jen Liou, Man Lyang Kim, Won Do Heo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2005.05.055"}], "href": "https://doi.org/10.1016/j.cub.2005.05.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16005298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16005298"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria A Spassova, Jonathan Soboloff, Li-Ping He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0510050103"}], "href": "https://doi.org/10.1073/pnas.0510050103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16537481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16537481"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christine Peinelt, Monika Vig, Dana L Koomoa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amplification of CRAC current by STIM1 and CRACM1 (Orai1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1435"}], "href": "https://doi.org/10.1038/ncb1435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16733527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16733527"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jonathan Soboloff, Maria A Spassova, Xiang D Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orai1 and STIM reconstitute store-operated calcium channel function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C600126200"}], "href": "https://doi.org/10.1074/jbc.C600126200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16766533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16766533"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jonathan Soboloff, Maria A Spassova, Thamara Hewavitharana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2006.05.051"}], "href": "https://doi.org/10.1016/j.cub.2006.05.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16860747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16860747"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "José J López, Ginés M Salido, José A Pariente, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604272200"}], "href": "https://doi.org/10.1074/jbc.M604272200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16870612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16870612"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Guo N Huang, Weizhong Zeng, Joo Young Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1454"}], "href": "https://doi.org/10.1038/ncb1454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16906149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16906149"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Minnie M Wu, JoAnn Buchanan, Riina M Luik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200604014"}], "href": "https://doi.org/10.1083/jcb.200604014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16966422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16966422"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Joseph P Yuan, Weizhong Zeng, Guo N Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1590"}], "href": "https://doi.org/10.1038/ncb1590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17486119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17486119"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jen Liou, Marc Fivaz, Takanari Inoue, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M704339200"}], "href": "https://doi.org/10.1074/jbc.M704339200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17684017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17684017"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zhengzheng Li, Jingze Lu, Pingyong Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703573200"}], "href": "https://doi.org/10.1074/jbc.M703573200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17702753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17702753"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Martin Muik, Irene Frischauf, Isabella Derler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M708898200"}], "href": "https://doi.org/10.1074/jbc.M708898200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18187424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18187424"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ilya Grigoriev, Susana Montenegro Gouveia, Babet van der Vaart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2007.12.050"}], "href": "https://doi.org/10.1016/j.cub.2007.12.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18249114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18249114"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Maria I Lioudyno, J Ashot Kozak, Aubin Penna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0706122105"}], "href": "https://doi.org/10.1073/pnas.0706122105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18250319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18250319"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kwong Tai Cheng, Xibao Liu, Hwei Ling Ong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C800008200"}], "href": "https://doi.org/10.1074/jbc.C800008200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18326500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18326500"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Christine Peinelt, Annette Lis, Andreas Beck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2008.151365"}], "href": "https://doi.org/10.1113/jphysiol.2008.151365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18403424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18403424"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Charbel El Boustany, Gabriel Bidaux, Antoine Enfissi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000338496.95579.56"}], "href": "https://doi.org/10.1161/01.RES.0000338496.95579.56"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18845811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18845811"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Peter B Stathopulos, Le Zheng, Guang-Yao Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.09.020"}], "href": "https://doi.org/10.1016/j.molcel.2008.09.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18995841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18995841"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Joseph P Yuan, Weizhong Zeng, Michael R Dorwart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOAR and the polybasic STIM1 domains gate and regulate Orai channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1842"}], "href": "https://doi.org/10.1038/ncb1842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19182790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19182790"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Shengyu Yang, J Jillian Zhang, Xin-Yun Huang "}, {"type": "b", "children": [{"type": "t", "text": "Orai1 and STIM1 are critical for breast tumor cell migration and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2008.12.019"}], "href": "https://doi.org/10.1016/j.ccr.2008.12.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19185847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19185847"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Martin Muik, Marc Fahrner, Isabella Derler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C800229200"}], "href": "https://doi.org/10.1074/jbc.C800229200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19189966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19189966"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Chan Young Park, Paul J Hoover, Franklin M Mullins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.02.014"}], "href": "https://doi.org/10.1016/j.cell.2009.02.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19249086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19249086"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wayne I DeHaven, Bertina F Jones, John G Petranka, et al. 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Synonyms	STRMK, TAM1, D11S4896E, IMD10, GOK, TAM
Proteins	STIM1_HUMAN
NCBI Gene ID	6786
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STIM1 has 9,803 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for STIM1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STIM1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STIM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STIM1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STIM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STIM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STIM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of STIM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STIM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STIM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STIM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with STIM1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STIM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STIM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STIM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with STIM1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of STIM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STIM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STIM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing STIM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing STIM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STIM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STIM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STIM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STIM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with STIM1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with STIM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with STIM1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of STIM1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STIM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving STIM1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving STIM1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with STIM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with STIM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STIM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STIM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STIM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with STIM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STIM1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STIM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of STIM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing STIM1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.