STMN2 Gene

Name	stathmin 2
Description	This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTMN2 (also known as stathmin‐2 or SCG10) is a neuron‐specific microtubule regulator that plays a crucial role in axonal outgrowth, regeneration, and overall neuronal maintenance. Its expression is tightly controlled by TDP‐43, as demonstrated by studies showing that depletion or mislocalization of TDP‐43 leads to aberrant splicing events resulting in a truncated, non‐functional STMN2 transcript. This loss of proper STMN2 expression compromises normal neurite extension and axonal regeneration, and is implicated in neurodegenerative conditions including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson’s disease. In these contexts, reduced or improperly processed STMN2 correlates with impaired synaptic function and neuronal vulnerability, whereas restoration or post‐translational stabilization of STMN2 can rescue deficits in axonal regeneration and improve neuronal integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in regeneration, STMN2 functions as a key effector in modulating microtubule dynamics, which is fundamental not only for proper neurite extension but also for signal transduction and cellular differentiation. Interactions with regulatory proteins such as RGS6 and Rnd1 have been shown to potentiate STMN2’s ability to remodel the microtubule network—stabilizing plus-end growth while promoting controlled destabilization at minus ends—to drive axon formation and neuronal differentiation. Moreover, alterations in STMN2 (or its protein product SCG10) expression have been associated with oncogenic processes, such as enhanced invasive behavior in metastatic gastric cancer cells, and in models of familial dysautonomia where its upregulation links to disrupted cytoskeletal organization. Together, these findings underscore STMN2’s multifaceted functions in maintaining neuronal cytoskeletal integrity, facilitating synaptic trafficking, and potentially linking cytoskeletal dynamics to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joseph R Klim, Luis A Williams, Francesco Limone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41593-018-0300-4"}], "href": "https://doi.org/10.1038/s41593-018-0300-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30643292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30643292"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ze'ev Melamed, Jone López-Erauskin, Michael W Baughn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41593-018-0293-z"}], "href": "https://doi.org/10.1038/s41593-018-0293-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30643298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30643298"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qian Wang, Yuanxi Zhang, Minghui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-13144-y"}], "href": "https://doi.org/10.1038/s41467-019-13144-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31748532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31748532"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mercedes Prudencio, Jack Humphrey, Sarah Pickles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI139741"}], "href": "https://doi.org/10.1172/JCI139741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32790644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32790644"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhengyu Liu, Tapan K Chatterjee, Rory A Fisher "}, {"type": "b", "children": [{"type": "t", "text": "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205908200"}], "href": "https://doi.org/10.1074/jbc.M205908200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12140291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12140291"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tapas Manna, Gabriele Grenningloh, Herbert P Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi061819d"}], "href": "https://doi.org/10.1021/bi061819d"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17311410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17311410"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ying-Hua Li, Sharang Ghavampur, Percy Bondallaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M808126200"}], "href": "https://doi.org/10.1074/jbc.M808126200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18996843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18996843"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "David Cheishvili, Channa Maayan, Rachel Cohen-Kupiec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr036"}], "href": "https://doi.org/10.1093/hmg/ddr036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21273291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21273291"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Q Guo, N Su, J Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.296"}], "href": "https://doi.org/10.1038/onc.2013.296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23893240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23893240"}]}]}]}
Synonyms	SCGN10, SCG10
Proteins	STMN2_HUMAN
NCBI Gene ID	11075
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STMN2 has 6,639 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for STMN2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STMN2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STMN2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STMN2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of STMN2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STMN2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STMN2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STMN2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of STMN2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STMN2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STMN2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of STMN2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STMN2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STMN2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with STMN2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with STMN2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STMN2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STMN2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STMN2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing STMN2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of STMN2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STMN2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STMN2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STMN2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STMN2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STMN2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STMN2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with STMN2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of STMN2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STMN2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with STMN2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STMN2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STMN2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STMN2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with STMN2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STMN2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STMN2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of STMN2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing STMN2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with STMN2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with STMN2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of STMN2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.