STMN3 Gene

Name	stathmin-like 3
Description	This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTMN3 (also known as SCLIP) is a member of the stathmin phosphoprotein family that modulates microtubule dynamics by sequestering tubulin. Unlike its neural‐enriched paralogs, STMN3 displays a broader tissue distribution, suggesting additional functions outside the nervous system. Analysis of its regulatory elements, including NRSE-like sequences with low affinity for NRSF, implies that coexpression with other stathmin family members may provide functional redundancy in various tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, STMN3 plays a critical role in the regulated secretory pathway. Investigations into its interaction with chromogranin A (CHGA) revealed that STMN3 colocalizes with CHGA in the Golgi apparatus, and its downregulation disrupts the secretion of CHGA and other secreted proteins. Moreover, alterations in its expression and posttranslational modifications can impact its microtubule-destabilizing activity, thereby modulating cellular responses to drugs such as paclitaxel, where reduced STMN3 function enhances mitotic arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in secretion, STMN3 is important for neuronal development and cell morphology. It is a substrate for kinases such as GSK-3β, which directs its subcellular localization to neuritic tips and growth cones, an essential aspect of axonal morphogenesis. In cancer contexts, STMN3 interacts with STAT3 to maintain protein stability, contributing to the preservation of epithelial morphology in breast cancer cells, while its overexpression in gliomas is associated with enhanced cell migration, invasion, and proliferation. These observations highlight STMN3 as a key modulator in both normal cellular development and oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ivan Bièche, Alexandre Maucuer, Ingrid Laurendeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0888-7543(03)00031-4"}], "href": "https://doi.org/10.1016/s0888-7543(03"}, {"type": "t", "text": "00031-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12676564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12676564"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nitish R Mahapatra, Laurent Taupenot, Maite Courel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi7019996"}], "href": "https://doi.org/10.1021/bi7019996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18549247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18549247"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xuemei Xie, Chandra Bartholomeusz, Ahmed A Ahmed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-12-0737"}], "href": "https://doi.org/10.1158/1535-7163.MCT-12-0737"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23543364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23543364"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Y Yip, Yvonne Y C Yeap, Marie A Bogoyevitch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.02.101"}], "href": "https://doi.org/10.1016/j.bbrc.2014.02.101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24589734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24589734"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sara Devaux, Fabienne E Poulain, Véronique Devignot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.344044"}], "href": "https://doi.org/10.1074/jbc.M112.344044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22577147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22577147"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dominic C H Ng, Cheh P Lim, Bao H Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20091213"}], "href": "https://doi.org/10.1042/BJ20091213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19824884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19824884"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yanmin Zhang, Shilei Ni, Bin Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of SCLIP promotes growth and motility in glioblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/15384047.2014.987037"}], "href": "https://doi.org/10.4161/15384047.2014.987037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25511414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25511414"}]}]}]}
Synonyms	SCLIP
Proteins	STMN3_HUMAN
NCBI Gene ID	50861
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STMN3 has 5,577 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for STMN3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STMN3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STMN3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STMN3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of STMN3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STMN3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STMN3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STMN3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of STMN3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STMN3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STMN3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of STMN3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STMN3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STMN3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with STMN3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with STMN3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STMN3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STMN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STMN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing STMN3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of STMN3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STMN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STMN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STMN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STMN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STMN3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STMN3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with STMN3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with STMN3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of STMN3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STMN3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with STMN3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STMN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STMN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STMN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with STMN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STMN3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STMN3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of STMN3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing STMN3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of STMN3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with STMN3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.