STX8 Gene

HGNC Family	Syntaxins (STX)
Name	syntaxin 8
Description	The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSyntaxin 8 (STX8) is a Qc‐SNARE protein that plays key roles in regulating membrane trafficking. Notably, STX8 physically interacts with the cystic fibrosis transmembrane conductance regulator (CFTR) and its associated SNARE partners to modulate CFTR’s delivery to the plasma membrane, ultimately inhibiting CFTR‐mediated chloride currents. These findings point to a critical role for STX8 in controlling both the trafficking and activity of ion channels, which may impact epithelial physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn platelets, STX8 is selectively expressed and contributes specifically to dense granule secretion. Mouse models lacking STX8 display impaired dense granule release upon agonist stimulation, which adversely affects platelet aggregation and thrombus stabilization. This highlights the role of STX8 in finely tuning secretion processes that are essential for normal hemostasis and thrombosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in CFTR regulation and platelet function, STX8 interacts with tight junction proteins such as Claudin-16. In epithelial cells, STX8 controls the recycling of Claudin-16, thereby influencing its cell-surface localization and modulating paracellular ion permeability. Additionally, studies identifying distinct di-leucine-based motifs within STX8 reveal that these motifs independently regulate its endocytosis, further clarifying the mechanisms by which STX8 governs vesicular trafficking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging research also indicates that STX8 may have roles in unconventional secretion processes. Recent commentary suggests that the transmembrane domains of STX8, alongside those of syntaxin 6, can be exploited to facilitate the release of misfolded tau—a process with potential implications in the progression of tauopathies, including Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, there is preliminary evidence linking STX8 function to metabolic regulation. Studies in the context of obesity and type 2 diabetes have implicated STX8 in endosomal transport processes that may influence adipose tissue inflammation and metabolic homeostasis, although further work is needed to clarify its precise role in these disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Frédéric Bilan, Vincent Thoreau, Magali Nacfer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01070"}], "href": "https://doi.org/10.1242/jcs.01070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15039462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15039462"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Frédéric Bilan, Magali Nacfer, Fleur Fresquet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2008.04.012"}], "href": "https://doi.org/10.1016/j.yexcr.2008.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18570918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18570918"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ewelina M Golebiewska, Matthew T Harper, Christopher M Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.602615"}], "href": "https://doi.org/10.1074/jbc.M114.602615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25404741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25404741"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kazuo Kasai, Kei Suga, Tetsuro Izumi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syntaxin 8 has two functionally distinct di-leucine-based motifs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2478/s11658-007-0043-9"}], "href": "https://doi.org/10.2478/s11658-007-0043-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17965969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17965969"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Vijay Renigunta, Thomas Fischer, Marylou Zuzarte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-10-0592"}], "href": "https://doi.org/10.1091/mbc.E13-10-0592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24743596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24743596"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hao Xu 徐昊 "}, {"type": "b", "children": [{"type": "t", "text": "Smuggle tau through a secret(ory) pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20210324"}], "href": "https://doi.org/10.1042/BCJ20210324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34319403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34319403"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Andoni Lancha, Santiago López-Garrido, Amaia Rodríguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of syntaxin 8 in visceral adipose tissue is increased in obese patients with type 2 diabetes and related to markers of insulin resistance and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Med Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.arcmed.2014.12.003"}], "href": "https://doi.org/10.1016/j.arcmed.2014.12.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25523146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25523146"}]}]}]}
Synonyms	CARB
Proteins	STX8_HUMAN
NCBI Gene ID	9482
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STX8 has 5,631 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for STX8 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STX8 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STX8 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STX8 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STX8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STX8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STX8 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of STX8 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STX8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STX8 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STX8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STX8 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with STX8 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with STX8 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STX8 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STX8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STX8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of STX8 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STX8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STX8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing STX8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing STX8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STX8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STX8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing STX8 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STX8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STX8 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with STX8 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with STX8 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with STX8 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STX8 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with STX8 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STX8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STX8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STX8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with STX8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STX8 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STX8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of STX8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing STX8 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with STX8 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with STX8 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.