STXBP5 Gene

HGNC Family	WD repeat domain containing (WDR)
Name	syntaxin binding protein 5 (tomosyn)
Description	Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTXBP5, also known as tomosyn, is a key regulator of SNARE‐dependent exocytosis in neuronal cells. Early studies identified tomosyn as a syntaxin‐1–binding protein that interferes with the normal formation of the synaptic SNARE complex, thereby reducing Ca²⁺‐dependent neurotransmitter release. Detailed structural analyses revealed that, beyond its conserved SNARE motif, additional loop domains are critical for its inhibitory function, and post‐translational modifications such as SUMOylation can modulate its interactions with SNARE partners."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the vascular and hemostatic systems, STXBP5 plays a dual role. Genetic studies have linked STXBP5 variants with altered von Willebrand factor (VWF) plasma levels and an increased risk for thrombosis, indicating that STXBP5 function influences vascular health. In endothelial cells, STXBP5 interacts with syntaxin-4 to inhibit the regulated exocytosis of VWF and P-selectin, while in platelets, it is essential for proper granule cargo packaging and stimulus-dependent secretion. Deficiency of STXBP5 leads to abnormalities in platelet secretion and impaired hemostasis, and genetic analyses in type 1 von Willebrand disease patients further support an association between certain STXBP5 haplotypes and bleeding phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSTXBP5 also regulates secretory processes in metabolic and immune cells. In pancreatic β-cells and adipocytes, tomosyn suppresses insulin and GLUT4 exocytosis until signals—such as glucose-stimulated de-SUMOylation or NSF/α-SNAP action—release the block on SNARE assembly, thereby modulating the secretory response essential for glucose homeostasis. In mast cells, phosphorylation of STXBP5 triggers a switch in its SNARE interactions, which results in inhibition of IgE-receptor–stimulated degranulation; intriguingly, elevated tomosyn levels observed in allergic patients may represent a counterregulatory mechanism to limit excessive mediator release."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also points to roles for non-coding transcripts associated with STXBP5. Specifically, the long non-coding RNA STXBP5-AS1, which is transcribed antisense to STXBP5, is downregulated in certain tumors such as cervical cancer and glioma. Functional studies suggest that STXBP5-AS1 acts as a competing endogenous RNA to modulate microRNA levels and thereby influence tumor suppressor pathways, affecting cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Fujita, H Shirataki, T Sakisaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (1998)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0896-6273(00)80472-9"}], "href": "https://doi.org/10.1016/s0896-6273(00"}, {"type": "t", "text": "80472-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "9620695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/9620695"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S Yokoyama, H Shirataki, T Sakisaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three splicing variants of tomosyn and identification of their syntaxin-binding region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1999)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bbrc.1999.0300"}], "href": "https://doi.org/10.1006/bbrc.1999.0300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10066450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10066450"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Antionette L Williams, Noa Bielopolski, Daphna Meroz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.215624"}], "href": "https://doi.org/10.1074/jbc.M110.215624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21330375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21330375"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yun Li, Shen Wang, Tianzhi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.13018"}], "href": "https://doi.org/10.1002/1873-3468.13018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29485200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29485200"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nicholas L Smith, Kenneth M Rice, Edwin G Bovill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-10-315473"}], "href": "https://doi.org/10.1182/blood-2010-10-315473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21163921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21163921"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiuyu Zhu, Munekazu Yamakuchi, Sara Ture, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI71245"}], "href": "https://doi.org/10.1172/JCI71245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25244095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25244095"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shaojing Ye, Yunjie Huang, Smita Joshi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Platelet secretion and hemostasis require syntaxin-binding protein STXBP5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI75572"}], "href": "https://doi.org/10.1172/JCI75572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25244094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25244094"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Janine E van Loon, Frank W G Leebeek, Jaap W Deckers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of genetic variations in syntaxin-binding protein-5 and syntaxin-2 on von Willebrand factor concentration and cardiovascular risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Cardiovasc Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCGENETICS.110.957407"}], "href": "https://doi.org/10.1161/CIRCGENETICS.110.957407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21156930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21156930"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Janine E van Loon, Yvonne V Sanders, Eva M de Wee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040624"}], "href": "https://doi.org/10.1371/journal.pone.0040624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22792389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22792389"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Qiuyu Martin Zhu, Kyung Ae Ko, Sara Ture, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.116.308614"}], "href": "https://doi.org/10.1161/ATVBAHA.116.308614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28062498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28062498"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Christina Lind-Halldén, Eric Manderstedt, Daniel Carlberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Variation in the Syntaxin-Binding Protein STXBP5 in Type 1 von Willebrand Disease Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-0038-1661352"}], "href": "https://doi.org/10.1055/s-0038-1661352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29972863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29972863"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Maaike Schillemans, Ellie Karampini, Arie J Hoogendijk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2019.103417"}], "href": "https://doi.org/10.1016/j.jprot.2019.103417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31201948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31201948"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mourad Ferdaoussi, Jianyang Fu, Xiaoqing Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-00344-z"}], "href": "https://doi.org/10.1038/s41598-017-00344-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28325894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28325894"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shifeng Wang, Yinghui Liu, Lauren Crisman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/tra.12760"}], "href": "https://doi.org/10.1111/tra.12760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32851733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32851733"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Iris K Madera-Salcedo, Luca Danelli, Neeraj Tiwari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aan4350"}], "href": "https://doi.org/10.1126/scisignal.aan4350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29970602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29970602"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shiqing Shao, Chen Wang, Shelian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA STXBP5-AS1 suppressed cervical cancer progression via targeting miR-96-5p/PTEN axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109082"}], "href": "https://doi.org/10.1016/j.biopha.2019.109082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31212131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31212131"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jing Wang, Lei Yang, Yuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant hypermethylation induced downregulation of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with tumorigenesis of glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2021.119590"}], "href": "https://doi.org/10.1016/j.lfs.2021.119590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33965377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33965377"}]}]}]}
Synonyms	LLGL3, LGL3, NBLA04300
Proteins	STXB5_HUMAN
NCBI Gene ID	134957
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STXBP5 has 5,344 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for STXBP5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STXBP5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STXBP5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STXBP5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STXBP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STXBP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STXBP5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STXBP5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STXBP5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STXBP5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STXBP5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with STXBP5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with STXBP5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STXBP5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STXBP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STXBP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STXBP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STXBP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing STXBP5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing STXBP5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STXBP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STXBP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STXBP5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STXBP5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with STXBP5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with STXBP5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with STXBP5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of STXBP5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STXBP5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with STXBP5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with STXBP5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STXBP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STXBP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STXBP5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STXBP5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STXBP5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of STXBP5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing STXBP5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with STXBP5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with STXBP5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with STXBP5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing STXBP5 from the GeneSigDB Published Gene Signatures dataset.