{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe body of work presented by these studies overwhelmingly characterizes SIRT1—a NAD⁺‐dependent deacetylase—as a master regulator of diverse processes including stress resistance, metabolism, circadian rhythm, autophagy, genomic stability, and cell survival. Together, these investigations describe how SIRT1 modulates transcriptional programs by deacetylating key substrates such as FOXO transcription factors, p53, PGC-1α, and nuclear receptors; they further demonstrate how SIRT1 activation (by caloric restriction, resveratrol, or genetic overexpression) improves metabolic homeostasis, enhances mitochondrial function, and confers resistance to age‐associated or stress‐induced damage."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, amid this extensive exploration of metabolic regulation, cellular differentiation, stress responses, and aging, none of the studies mention SUPT20H or provide direct evidence regarding its function. In the context of these abstracts, while SIRT1 and its downstream signaling are shown to affect deacetylation events, transcriptional control, and metabolic adaptations, the role of SUPT20H remains uncharacterized. Thus, from the current collection of literature it is not possible to infer any functional involvement or biological contribution for SUPT20H, underscoring the need for targeted investigations to elucidate whether SUPT20H might interface with these regulatory pathways or serve distinct cellular roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Luo, A Y Nikolaev, S Imai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0400593101"}], "href": "https://doi.org/10.1073/pnas.0400593101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15220471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15220471"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Toshiyuki Araki, Yo Sasaki, Jeffrey Milbrandt "}, {"type": "b", "children": [{"type": "t", "text": "Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1098014"}], "href": "https://doi.org/10.1126/science.1098014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15310905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15310905"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Javier R Revollo, Andrew A Grimm, Shin-ichiro Imai "}, {"type": "b", "children": [{"type": "t", "text": "The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408388200"}], "href": "https://doi.org/10.1074/jbc.M408388200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15381699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15381699"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Joseph T Rodgers, Carlos Lerin, Wilhelm Haas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature03354"}], "href": "https://doi.org/10.1038/nature03354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15744310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15744310"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Weiping Qin, Tianle Yang, Lap Ho, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M609554200"}], "href": "https://doi.org/10.1074/jbc.M609554200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17197703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17197703"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zachary Gerhart-Hines, Joseph T Rodgers, Olivia Bare, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601633"}], "href": "https://doi.org/10.1038/sj.emboj.7601633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17347648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17347648"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ralph R Alcendor, Shumin Gao, Peiyong Zhai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sirt1 regulates aging and resistance to oxidative stress in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000267723.65696.4a"}], "href": "https://doi.org/10.1161/01.RES.0000267723.65696.4a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17446436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17446436"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dohoon Kim, Minh Dang Nguyen, Matthew M Dobbin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2007.08.014"}], "href": "https://doi.org/10.1016/j.cmet.2007.08.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17908559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17908559"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiaoling Li, Songwen Zhang, Gil Blander, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 deacetylates and positively regulates the nuclear receptor LXR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.07.032"}], "href": "https://doi.org/10.1016/j.molcel.2007.07.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17936707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17936707"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Michael Potente, Laleh Ghaeni, Danila Baldessari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 controls endothelial angiogenic functions during vascular growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.435107"}], "href": "https://doi.org/10.1101/gad.435107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17938244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17938244"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "In Hye Lee, Liu Cao, Raul Mostoslavsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0712145105"}], "href": "https://doi.org/10.1073/pnas.0712145105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18296641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18296641"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Danica Chen, Joanne Bruno, Erin Easlon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-specific regulation of SIRT1 by calorie restriction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1650608"}], "href": "https://doi.org/10.1101/gad.1650608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18550784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18550784"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Paul T Pfluger, Daniel Herranz, Susana Velasco-Miguel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sirt1 protects against high-fat diet-induced metabolic damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0802917105"}], "href": "https://doi.org/10.1073/pnas.0802917105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18599449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18599449"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Carles Cantó, Zachary Gerhart-Hines, Jerome N Feige, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07813"}], "href": "https://doi.org/10.1038/nature07813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19262508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19262508"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yasukazu Nakahata, Saurabh Sahar, Giuseppe Astarita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1170803"}], "href": "https://doi.org/10.1126/science.1170803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19286518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19286518"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Aparna Purushotham, Thaddeus T Schug, Qing Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2009.02.006"}], "href": "https://doi.org/10.1016/j.cmet.2009.02.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19356714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19356714"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shinji Kume, Takashi Uzu, Kihachiro Horiike, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI41376"}], "href": "https://doi.org/10.1172/JCI41376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20335657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20335657"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08991"}], "href": "https://doi.org/10.1038/nature08991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20357764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20357764"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jun Gao, Wen-Yuan Wang, Ying-Wei Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel pathway regulates memory and plasticity via SIRT1 and miR-134."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09271"}], "href": "https://doi.org/10.1038/nature09271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20622856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20622856"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Shaday Michán, Ying Li, Maggie Meng-Hsiu Chou, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.122978"}], "href": "https://doi.org/10.1074/jbc.M110.122978"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20817729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20817729"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Nirmala Hariharan, Yasuhiro Maejima, Jun Nakae, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2012.04.003"}], "href": "https://doi.org/10.1016/j.cmet.2012.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22560220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22560220"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Hung-Chun Chang, Leonard Guarente "}, {"type": "b", "children": [{"type": "t", "text": "SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2013.05.027"}], "href": "https://doi.org/10.1016/j.cell.2013.05.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23791176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23791176"}]}]}]}