SUPT3H Gene

Name	suppressor of Ty 3 homolog (S. cerevisiae)
Description	Enables transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of SAGA complex and transcription factor TFTC complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSUPT3H has emerged as an important gene in human growth regulation. Genome‐wide association studies have identified SUPT3H as one of several loci associated with height variation – a finding observed in Korean cohorts and further supported by studies in African Pygmy populations, where the SUPT3H-RUNX2 region has been implicated in bone homeostasis and skeletal development. Moreover, transmission distortion mapping in a chromosomal segment encompassing SUPT3H suggests that the locus undergoes non‐Mendelian inheritance, potentially contributing to the genetic architecture underlying stature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, SUPT3H functions as a core member of the human STAGA complex – the counterpart of yeast Spt3 – which plays a pivotal role in transcriptional activation. By directly interacting with the core Mediator complex, the STAGA complex facilitates the recruitment of key transcription components, such as TFIID and RNA polymerase II, particularly in MYC-driven gene expression. This cooperation underlies critical aspects of cell proliferation and gene regulation, emphasizing the central role of SUPT3H in modulating transcriptional programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in transcription, SUPT3H has been implicated in chromatin remodeling processes that impact disease pathways. For instance, allelic variation at an osteoarthritis risk locus has been shown to affect the expression of SUPT3H, suggesting that altered chromatin structure may contribute to joint degeneration. Similarly, specific variants in the SUPT3H locus have been associated with increased ADAMTS13 activity, linking the gene to regulatory mechanisms that extend beyond skeletal growth to encompass proteolytic processes and vascular biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jae-Jung Kim, Hae-In Lee, Taesung Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of 15 loci influencing height in a Korean population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2009.116"}], "href": "https://doi.org/10.1038/jhg.2009.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19893584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19893584"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Isabel Mendizabal, Urko M Marigorta, Oscar Lao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adaptive evolution of loci covarying with the human African Pygmy phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-012-1157-3"}], "href": "https://doi.org/10.1007/s00439-012-1157-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22407027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22407027"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pablo Sandro Carvalho Santos, Johannes Höhne, Peter Schlattmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2009.16"}], "href": "https://doi.org/10.1038/ejhg.2009.16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19259136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19259136"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaohui Liu, Marina Vorontchikhina, Yuan-Liang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01402-07"}], "href": "https://doi.org/10.1128/MCB.01402-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17967894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17967894"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sarah J Rice, Guillaume Aubourg, Antony K Sorial, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddy257"}], "href": "https://doi.org/10.1093/hmg/ddy257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30010910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30010910"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Paul S de Vries, Johan Boender, Michelle A H Sonneveld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in the ADAMTS13 and SUPT3H genes are associated with ADAMTS13 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-02-629865"}], "href": "https://doi.org/10.1182/blood-2015-02-629865"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25934476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25934476"}]}]}]}
Synonyms	SPT3, SPT3L
Proteins	SUPT3_HUMAN
NCBI Gene ID	8464
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SUPT3H has 7,209 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for SUPT3H from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SUPT3H Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SUPT3H gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SUPT3H gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SUPT3H gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SUPT3H gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SUPT3H gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SUPT3H gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SUPT3H gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SUPT3H gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SUPT3H gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SUPT3H gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SUPT3H gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SUPT3H gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SUPT3H gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SUPT3H gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SUPT3H gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SUPT3H protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SUPT3H protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SUPT3H protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SUPT3H protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SUPT3H protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SUPT3H gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SUPT3H gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SUPT3H gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SUPT3H gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SUPT3H gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SUPT3H protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SUPT3H gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SUPT3H gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SUPT3H gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SUPT3H gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SUPT3H gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SUPT3H gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SUPT3H gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SUPT3H gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SUPT3H gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SUPT3H gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SUPT3H from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SUPT3H gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SUPT3H gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SUPT3H gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.