SURF4 Gene

Name	surfeit 4
Description	This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSURF4 is a highly conserved, multi‐pass transmembrane cargo receptor that functions in the early secretory pathway to ensure efficient and selective export of a wide variety of soluble proteins. It achieves this by directly recognizing specific sequence motifs—such as amino‐terminal tripeptides (the ER-ESCAPE motif) and polybasic regions—on its cargo proteins. These include important regulatory molecules such as PCSK9, erythropoietin, and hedgehog family members, among others. Through physical interactions with partners like ERGIC-53, p24 proteins, and SEC24A, SURF4 facilitates incorporation into COPII-coated vesicles and promotes fast ER-to-Golgi trafficking, even contributing to the biogenesis of specialized tubular ER-Golgi intermediate compartments that accelerate cargo transport."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its canonical role in managing soluble cargo export, SURF4 is critically involved in regulating lipid homeostasis. It functions in the secretion of lipid-laden particles by partnering with the COPII machinery, an activity that is essential for the efficient export of lipoprotein components such as apolipoprotein B. Hepatic inactivation of SURF4 or its orthologues leads to dramatic reductions in plasma lipid levels and protects against atherosclerosis, highlighting its dosage-sensitive role in lipid metabolism. Its broader regulatory capacity in lipid trafficking is further underscored by reviews summarizing these multifaceted processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in secretion and lipid regulation, SURF4 is co-opted by certain positive-strand RNA viruses. In the context of viral replication, particularly for hepatitis C virus and poliovirus, SURF4 is recruited by viral proteins to the replication complex, where it contributes to the formation and structural integrity of double-membrane vesicles that serve as viral RNA replication sites."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSURF4 also has an essential function in ensuring the proper intracellular trafficking of lysosomal proteins. It mediates the ER export of progranulin by forming a complex with prosaposin, thereby promoting efficient delivery of these proteins to the lysosome. This role is critical, considering that deficiencies in progranulin trafficking are associated with neurodegenerative diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, aberrant regulation of SURF4 has been implicated in oncogenesis. Amplification and increased expression of SURF4 have been observed in several human cancers including breast cancer, where its overexpression promotes enhanced cell proliferation, migration, and anchorage-independent growth. These findings suggest that, in addition to its homeostatic functions in secretion, SURF4 may serve as a diagnostic biomarker and potential therapeutic target in the context of cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandra Mitrovic, Houchaima Ben-Tekaya, Eva Koegler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-10-0989"}], "href": "https://doi.org/10.1091/mbc.e07-10-0989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18287528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18287528"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Brian T Emmer, Geoffrey G Hesketh, Emilee Kotnik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.38839"}], "href": "https://doi.org/10.7554/eLife.38839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30251625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30251625"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ying Yin, Mekka R Garcia, Alexander J Novak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.2005140"}], "href": "https://doi.org/10.1371/journal.pbio.2005140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30086131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30086131"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zesen Lin, Richard King, Vi Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00180-20"}], "href": "https://doi.org/10.1128/MCB.00180-20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32989016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32989016"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rui Yan, Kun Chen, Bowen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2021.12.018"}], "href": "https://doi.org/10.1016/j.devcel.2021.12.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35051356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35051356"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiao Tang, Rong Chen, Vince St Dollente Mesias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2113991119"}], "href": "https://doi.org/10.1073/pnas.2113991119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35271396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35271396"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Natalia Gomez-Navarro, Julija Maldutyte, Kristina Poljak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2202080119"}], "href": "https://doi.org/10.1073/pnas.2202080119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35901214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35901214"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiao Tang, Tingxuan Wang, Yusong Guo "}, {"type": "b", "children": [{"type": "t", "text": "Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.102687"}], "href": "https://doi.org/10.1016/j.jbc.2022.102687"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36370847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36370847"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiao Wang, Huimin Wang, Bolin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2020.10.020"}], "href": "https://doi.org/10.1016/j.cmet.2020.10.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33186557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33186557"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Keiko Saegusa, Miyuki Sato, Nobukatsu Morooka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201708115"}], "href": "https://doi.org/10.1083/jcb.201708115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29643117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29643117"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yishi Shen, Hong-Mei Gu, Shucun Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Surf4, cargo trafficking, lipid metabolism, and therapeutic implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjac063"}], "href": "https://doi.org/10.1093/jmcb/mjac063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36574593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36574593"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lingbao Kong, Haruyo Aoyagi, Zibing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Surfeit 4 Contributes to the Replication of Hepatitis C Virus Using Double-Membrane Vesicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00858-19"}], "href": "https://doi.org/10.1128/JVI.00858-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31645450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31645450"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Swathi Devireddy, Shawn M Ferguson "}, {"type": "b", "children": [{"type": "t", "text": "Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202104044"}], "href": "https://doi.org/10.1083/jcb.202104044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34919127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34919127"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jayoung Kim, Chae Mi Hong, Su Min Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SURF4 has oncogenic potential in NIH3T3 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.05.116"}], "href": "https://doi.org/10.1016/j.bbrc.2018.05.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29777698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29777698"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jingtong Zhai, Jiashu Han, Cong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High SURF4 expression is associated with poor prognosis of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.204409"}], "href": "https://doi.org/10.18632/aging.204409"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36446386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36446386"}]}]}]}
Synonyms	ERV29
Proteins	SURF4_HUMAN
NCBI Gene ID	6836
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SURF4 has 6,750 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 106 datasets.

Click the + buttons to view associations for SURF4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SURF4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SURF4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SURF4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SURF4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SURF4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SURF4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SURF4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SURF4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SURF4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SURF4 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SURF4 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SURF4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SURF4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SURF4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SURF4 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SURF4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SURF4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SURF4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SURF4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SURF4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SURF4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SURF4 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SURF4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SURF4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SURF4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SURF4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SURF4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SURF4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SURF4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SURF4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SURF4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SURF4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SURF4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SURF4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SURF4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SURF4 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SURF4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SURF4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of SURF4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SURF4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of SURF4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.