{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts reveals a broad and detailed exploration of steroid hormone biosynthesis—in particular, the crucial role of cytochrome P450 side‐chain cleavage enzyme (CYP11A1) and its transcriptional regulation by factors such as SF‑1, CREB‑1, AP‑2, and others. These studies describe how CYP11A1 activity governs steroid production in tissues ranging from the adrenal glands and gonads to the placenta, immune cells, and even skeletal muscle, and how its dysregulation contributes to conditions such as steroid deficiency syndromes, reproductive dysfunctions, and developmental or stress‐related pathologies (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations focus on external stressors and their impact on steroidogenesis. For example, prenatal ethanol exposure, cadmium toxicity, and environmental contaminants are shown to modulate the expression and function of key steroidogenic enzymes, thereby affecting physiological processes such as immune cell differentiation, metabolic regulation, and neurodevelopment. Collectively, these studies underscore the complexity of endocrine signaling and the tightly controlled mechanisms that balance steroid hormone production under both normal and stress conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research delves into the intracellular mechanisms that ensure proper enzyme localization and function, such as the mitochondrial targeting of CYP11A1, the involvement of autophagy, and the epigenetic control of steroidogenic gene expression. Importantly, despite this wealth of information on steroid biosynthetic pathways and their regulation in diverse biological contexts, none of the studies provide any data or analysis regarding SUSD1. In other words, while the abstracts richly detail the regulatory networks surrounding CYP11A1 and other steroidogenic factors, they do not address a role for SUSD1 in these or related processes. Consequently, the function of SUSD1 remains uncharacterized in the context of these published works."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "26"}]}, {"type": "t", "text": " \n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meng-Chun Hu, Nai-Chi Hsu, Noomen Ben El Hadj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2002-0055"}], "href": "https://doi.org/10.1210/me.2002-0055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12145347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12145347"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gai Liang, Man Chen, Xiao-liang Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ethanol-induced inhibition of fetal hypothalamic-pituitary-adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Toxicol Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.etp.2010.04.015"}], "href": "https://doi.org/10.1016/j.etp.2010.04.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20627497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20627497"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan-Li Ji, Hua Wang, Ping Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Toxicol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.reprotox.2009.10.014"}], "href": "https://doi.org/10.1016/j.reprotox.2009.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19897027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19897027"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Noa Sher, Natalie Yivgi-Ohana, Joseph Orly "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of the cholesterol side chain cleavage cytochrome P450 gene (CYP11A1) revisited: binding of GATA, cyclic adenosine 3',5'-monophosphate response element-binding protein and activating protein (AP)-1 proteins to a distal novel cluster of cis-regulatory elements potentiates AP-2 and steroidogenic factor-1-dependent gene expression in the rodent placenta and ovary."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2006-0226"}], "href": "https://doi.org/10.1210/me.2006-0226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17213386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17213386"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Micha Ben-Zimra, Moriah Koler, Joseph Orly "}, {"type": "b", "children": [{"type": "t", "text": "Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2002-0056"}], "href": "https://doi.org/10.1210/me.2002-0056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12145340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12145340"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wei-Yi Chen, Jui-Hsia Weng, Chen-Che Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00476-07"}], "href": "https://doi.org/10.1128/MCB.00476-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17709382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17709382"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nadiya M Teplyuk, Ying Zhang, Yang Lou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2008-0270"}], "href": "https://doi.org/10.1210/me.2008-0270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19342447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19342447"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michaela Schedel, Yi Jia, Sven Michel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10213"}], "href": "https://doi.org/10.1038/ncomms10213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26750596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26750596"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yu Chien, Wei-Cheng Cheng, Menq-Rong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Misregulated progesterone secretion and impaired pregnancy in Cyp11a1 transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.113.110833"}], "href": "https://doi.org/10.1095/biolreprod.113.110833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23966322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23966322"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A H Payne, G L Youngblood, L Sha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (1992)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0960-0760(92)90317-C"}], "href": "https://doi.org/10.1016/0960-0760(92"}, {"type": "t", "text": "90317-C) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22217834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22217834"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chen-Che Jeff Huang, Meng-Chun Monica Shih, Nai-Chi Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2012-1258"}], "href": "https://doi.org/10.1210/en.2012-1258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22962254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22962254"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ing-Cherng Guo, Chiung-Yi Huang, Chi-Kuang Leo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3',5'-cyclic adenosine 5'-monophosphate-dependent human CYP11A1 transcription in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2006-0938"}], "href": "https://doi.org/10.1210/en.2006-0938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17218410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17218410"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Qingqing Chu, Zhi-Hong Chi, Xiuli Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A potential role for zinc transporter 7 in testosterone synthesis in mouse Leydig tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2016.2576"}], "href": "https://doi.org/10.3892/ijmm.2016.2576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27121848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27121848"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Meiqin Wang, Julita Ramirez, Junyan Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2013.05.027"}], "href": "https://doi.org/10.1016/j.jaci.2013.05.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23870673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23870673"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Perumal Elumalai, Gunasekaran Krishnamoorthy, Kandaswamy Selvakumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Toxicol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.reprotox.2008.11.053"}], "href": "https://doi.org/10.1016/j.reprotox.2008.11.053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19071209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19071209"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Meng-Chun Shih, Nai-Chi Hsu, Chen-Che Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation of mouse Cyp11a1 promoter caused tissue-specific reduction of gene expression and blunted stress response without affecting reproduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2007-0222"}], "href": "https://doi.org/10.1210/me.2007-0222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18174359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18174359"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shengyu Guan, Lu Xie, Teng Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of Melatonin on Early Pregnancy in Mouse: Involving the Regulation of StAR, Cyp11a1, and Ihh Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18081637"}], "href": "https://doi.org/10.3390/ijms18081637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28749439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28749439"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Natalia V Gómez, Alejandra B Gorostizaga, María M Mori Sequeiros García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAPK phosphatase-2 (MKP-2) is induced by hCG and plays a role in the regulation of CYP11A1 expression in MA-10 Leydig cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2012-2032"}], "href": "https://doi.org/10.1210/en.2012-2032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23471219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23471219"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hsin-Chieh Lan, Chih-Feng Wu, Hsiu-Ming Shih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.307603"}], "href": "https://doi.org/10.1074/jbc.M111.307603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22199361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22199361"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yongbo Guan, Pengfei Hao, Chunyu Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Effect of fluoride on the expression of StAR mRNA and P450scc mRNA in the progesterone synthesis of mouse Leydig tumor cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Wei Sheng Yan Jiu (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22443068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22443068"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "A N Minenko, L A Novikova, V N Luzikov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Import of hybrid forms of CYP11A1 into yeast mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2008.06.006"}], "href": "https://doi.org/10.1016/j.bbagen.2008.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18621100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18621100"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Chien Huang, Hsiu-Ju Hsu, Mu-En Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-92008-2"}], "href": "https://doi.org/10.1038/s41598-021-92008-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34131222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34131222"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Meng-Chun Monica Shih, Chen-Che Jeff Huang, Hsueh-Ping Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Embryonic Steroids Control Developmental Programming of Energy Balance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endocr/bqab196"}], "href": "https://doi.org/10.1210/endocr/bqab196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34599818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34599818"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Zequn Li, Haijiang Dong, Suchen Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FXR Maintains the Intestinal Barrier and Stemness by Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction Diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms241713494"}], "href": "https://doi.org/10.3390/ijms241713494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37686300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37686300"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Heng Yin, Jing Zhang, Yajun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Behav Immun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbi.2024.07.012"}], "href": "https://doi.org/10.1016/j.bbi.2024.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39025414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39025414"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jumpei Fujiki, Naoyuki Maeda, Kosuke Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2024.112336"}], "href": "https://doi.org/10.1016/j.mce.2024.112336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39094930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39094930"}]}]}]}