SUZ12 Gene

HGNC Family Zinc fingers
Name SUZ12 polycomb repressive complex 2 subunit
Description This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSUZ12 is a core subunit of the Polycomb Repressive Complex 2 (PRC2) that mediates epigenetic gene silencing by catalyzing trimethylation of histone H3 at lysine 27. This modification is essential for repressing key developmental regulators and maintaining the undifferentiated state of embryonic stem cells. In addition, recent studies further show that SUZ12 can cooperate with other factors and contribute to histone H3K9 methylation in differentiated cells, thereby integrating multiple chromatin‐based regulatory mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlterations in SUZ12 play critical roles in tumorigenesis. Loss-of-function mutations and deletions that inactivate SUZ12 result in a collapse of the H3K27 trimethylation mark in several cancers, including malignant peripheral nerve sheath tumors, T-cell acute lymphoblastic leukemia, and other aggressive neoplasms. In specific contexts such as peripheral nerve sheath tumors and high-grade gliomas, SUZ12 acts as a tumor suppressor, and its loss cooperates with mutations in NF1 and other oncogenic drivers to amplify aberrant Ras signaling. In T-ALL models, diminished PRC2 activity via SUZ12 inactivation contributes to oncogenic transcriptional reprogramming."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother recurrent mechanism affecting SUZ12 function is its involvement in chromosomal rearrangements and gene fusions. In endometrial stromal neoplasms, trans-splicing or chromosomal translocations fuse the 5′ exons of JAZF1 with sequences of the Polycomb group gene (historically called JJAZ1 and now recognized as SUZ12), generating chimeric transcripts that have anti-apoptotic activity. The frequency and structure of these JAZF1–SUZ12 fusions differ among classic endometrial stromal tumors compared to various morphologic variants, providing both diagnostic utility and insights into the biology of these tumors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPost‐transcriptional regulation of SUZ12 by microRNAs and other epigenetic modifiers also appears to be an important determinant of cancer progression. In breast cancer and lung tumors, downregulation of specific miRNAs such as miR‑200 and miR‑489 results in the upregulation of SUZ12, which then contributes to enhanced H3K27 trimethylation, repression of epithelial markers (for example, E-cadherin), and promotion of cancer stem cell properties, epithelial–mesenchymal transition, and chemoresistance. In epithelial ovarian, gastric, and colorectal cancers, aberrantly high expression of SUZ12 correlates with proliferative capacity, metastatic potential, and poorer clinical outcomes, suggesting its oncogenic role in these settings. Furthermore, in hepatitis B virus–associated hepatocarcinogenesis, oncogenic kinases induce SUZ12 degradation, thereby reprogramming the chromatin landscape."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic and tumor‐suppressive roles, alterations in SUZ12 are implicated in developmental disorders. Rare germline mutations in SUZ12 have been associated with Weaver-like overgrowth syndromes characterized by postnatal overgrowth, dysmorphic features, and variable neurodevelopmental deficits. Structural studies of SUZ12 within PRC2 complexes further reveal how its distinct domains mediate interactions with accessory factors, thereby dictating complex composition (PRC2.1 versus PRC2.2) and chromatin occupancy. In addition, signaling pathways such as those mediated by WNT proteins interface with SUZ12 regulation, underscoring its integration in both developmental and cancer-related transcriptional networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tong Ihn Lee, Richard G Jenner, Laurie A Boyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of developmental regulators by Polycomb in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.02.043"}], "href": "https://doi.org/10.1016/j.cell.2006.02.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16630818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16630818"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eva Madi Riising, Roberto Boggio, Susanna Chiocca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The polycomb repressive complex 2 is a potential target of SUMO modifications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0002704"}], "href": "https://doi.org/10.1371/journal.pone.0002704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18628979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18628979"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Miao-Chih Tsai, Ohad Manor, Yue Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA as modular scaffold of histone modification complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1192002"}], "href": "https://doi.org/10.1126/science.1192002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20616235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20616235"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Luciana Pizzatti, Renata Binato, Jaime Cofre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20722"}], "href": "https://doi.org/10.1002/gcc.20722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19847889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19847889"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "William Lee, Sewit Teckie, Thomas Wiesner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3095"}], "href": "https://doi.org/10.1038/ng.3095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25240281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25240281"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Thomas De Raedt, Eline Beert, Eric Pasmant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature13561"}], "href": "https://doi.org/10.1038/nature13561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25119042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25119042"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ming Zhang, Yuxuan Wang, Sian Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3116"}], "href": "https://doi.org/10.1038/ng.3116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25305755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25305755"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pierre Sohier, Armelle Luscan, Angharad Lloyd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.22446"}], "href": "https://doi.org/10.1002/gcc.22446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28124441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28124441"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Justin Korfhage, David B Lombard "}, {"type": "b", "children": [{"type": "t", "text": "Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-19-0147"}], "href": "https://doi.org/10.1158/1541-7786.MCR-19-0147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31023785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31023785"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Haishu Xie, Songsheng Shi, Quan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2019.152476"}], "href": "https://doi.org/10.1016/j.prp.2019.152476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31196742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31196742"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hsuan-Ying Huang, Marc Ladanyi, Robert A Soslow "}, {"type": "b", "children": [{"type": "t", "text": "Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00000478-200402000-00010"}], "href": "https://doi.org/10.1097/00000478-200402000-00010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15043312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15043312"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "H Kehrer-Sawatzki, L Kluwe, C Sandig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/423624"}], "href": "https://doi.org/10.1086/423624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15257518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15257518"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Marisa R Nucci, David Harburger, Jason Koontz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.pas.0000213327.86992.d1"}], "href": "https://doi.org/10.1097/01.pas.0000213327.86992.d1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17197920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17197920"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Esther Oliva, Laurence de Leval, Robert A Soslow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0b013e318031f012"}], "href": "https://doi.org/10.1097/PAS.0b013e318031f012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17667554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17667554"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hui Li, Xianyong Ma, Jinglan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0709986104"}], "href": "https://doi.org/10.1073/pnas.0709986104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18077430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18077430"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hui Li, Jinglan Wang, Gil Mor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1156725"}], "href": "https://doi.org/10.1126/science.1156725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18772439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18772439"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Joanna Boros, Nausica Arnoult, Vincent Stroobant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1α at chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00205-14"}], "href": "https://doi.org/10.1128/MCB.00205-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25047840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25047840"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Paul N Staats, Joaquin J Garcia, Dora C Dias-Santagata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0b013e3181a7b9cf"}], "href": "https://doi.org/10.1097/PAS.0b013e3181a7b9cf"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19542872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19542872"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dimitrios Iliopoulos, Marianne Lindahl-Allen, Christos Polytarchou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.08.013"}], "href": "https://doi.org/10.1016/j.molcel.2010.08.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20832727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20832727"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hua Li, Qi Cai, Hong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-12-0335"}], "href": "https://doi.org/10.1158/1541-7786.MCR-12-0335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22964433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22964433"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rui Xia, Fei-yan Jin, Kai Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3195-7"}], "href": "https://doi.org/10.1007/s13277-015-3195-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25672609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25672609"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zongtao Xie, Liming Cai, Runsheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3340-3"}], "href": "https://doi.org/10.1007/s13277-015-3340-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25833694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25833694"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Anne Benard, Inès J Goossens-Beumer, Anneke Q van Hoesel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0108265"}], "href": "https://doi.org/10.1371/journal.pone.0108265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25243792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25243792"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yan-Long Liu, Xu Gao, Yang Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-014-1854-5"}], "href": "https://doi.org/10.1007/s00432-014-1854-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25326896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25326896"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yannick D Benoit, Mavee S Witherspoon, Kristian B Laursen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2013.04.006"}], "href": "https://doi.org/10.1016/j.yexcr.2013.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23588203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23588203"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Dong-Qin Chen, Jia-Yuan Huang, Bing Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone deacetylase 1/Sp1/microRNA-200b signaling accounts for maintenance of cancer stem-like cells in human lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0109578"}], "href": "https://doi.org/10.1371/journal.pone.0109578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25279705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25279705"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Hao Zhang, Ahmed Diab, Huitao Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-2928"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-2928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25855382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25855382"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Wen-Horng Wang, Leo L Studach, Ourania M Andrisani "}, {"type": "b", "children": [{"type": "t", "text": "Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.24163"}], "href": "https://doi.org/10.1002/hep.24163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21480320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21480320"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Eri Imagawa, Ken Higashimoto, Yasunari Sakai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23200"}], "href": "https://doi.org/10.1002/humu.23200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28229514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28229514"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Siming Chen, Lianying Jiao, Murtada Shubbar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2018.01.039"}], "href": "https://doi.org/10.1016/j.molcel.2018.01.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29499137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29499137"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Sharri Cyrus, Deepika Burkardt, David D Weaver, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC2-complex related dysfunction in overgrowth syndromes: A review of EZH2, EED, and SUZ12 and their syndromic phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet C Semin Med Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.c.31754"}], "href": "https://doi.org/10.1002/ajmg.c.31754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31724824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31724824"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Sharri S Cyrus, Ana S A Cohen, Ruky Agbahovbe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare SUZ12 variants commonly cause an overgrowth phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet C Semin Med Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.c.31748"}], "href": "https://doi.org/10.1002/ajmg.c.31748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31736240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31736240"}]}]}]}
Synonyms CHET9, JJAZ1
Proteins SUZ12_HUMAN
NCBI Gene ID 23512
API
Download Associations
Predicted Functions View SUZ12's ARCHS4 Predicted Functions.
Co-expressed Genes View SUZ12's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SUZ12's ARCHS4 Predicted Functions.

Functional Associations

SUZ12 has 7,877 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for SUZ12 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by SUZ12 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SUZ12 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of SUZ12 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of SUZ12 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of SUZ12 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SUZ12 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
Biocarta Pathways pathways involving SUZ12 protein from the Biocarta Pathways dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of SUZ12 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SUZ12 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SUZ12 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SUZ12 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of SUZ12 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Gene Mutation Profiles cell lines with SUZ12 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with SUZ12 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with SUZ12 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SUZ12 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SUZ12 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SUZ12 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SUZ12 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing SUZ12 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing SUZ12 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing SUZ12 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with SUZ12 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SUZ12 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
CORUM Protein Complexes protein complexs containing SUZ12 protein from the CORUM Protein Complexes dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SUZ12 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with SUZ12 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with SUZ12 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with SUZ12 gene/protein from the curated CTD Gene-Disease Associations dataset.
DISEASES Curated Gene-Disease Association Evidence Scores diseases involving SUZ12 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving SUZ12 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with SUZ12 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SUZ12 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with SUZ12 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with SUZ12 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SUZ12 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SUZ12 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SUZ12 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing SUZ12 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of SUZ12 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with SUZ12 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SUZ12 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SUZ12 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SUZ12 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of SUZ12 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SUZ12 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SUZ12 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of SUZ12 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving SUZ12 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving SUZ12 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving SUZ12 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing SUZ12 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing SUZ12 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing SUZ12 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by SUZ12 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by SUZ12 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by SUZ12 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SUZ12 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SUZ12 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SUZ12 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of SUZ12 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of SUZ12 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of SUZ12 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of SUZ12 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SUZ12 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for SUZ12 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with SUZ12 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for SUZ12 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SUZ12 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate SUZ12 protein from the curated KEA Substrates of Kinases dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SUZ12 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SUZ12 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with SUZ12 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SUZ12 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of SUZ12 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of SUZ12 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SUZ12 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing SUZ12 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain SUZ12 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by SUZ12 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting SUZ12 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SUZ12 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by SUZ12 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for SUZ12 from the MSigDB Cancer Gene Co-expression Modules dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of SUZ12 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of SUZ12 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing SUZ12 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for SUZ12 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SUZ12 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of SUZ12 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving SUZ12 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving SUZ12 protein from the Wikipathways PFOCR 2024 dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate SUZ12 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
Reactome Pathways 2014 pathways involving SUZ12 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving SUZ12 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SUZ12 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SUZ12 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SUZ12 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of SUZ12 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SUZ12 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SUZ12 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SUZ12 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SUZ12 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with SUZ12 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs drug perturbations changing phosphorylation of SUZ12 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands ligand (protein) perturbations changing phosphorylation of SUZ12 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of SUZ12 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of SUZ12 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of SUZ12 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SUZ12 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of SUZ12 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SUZ12 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of SUZ12 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SUZ12 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with SUZ12 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SUZ12 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving SUZ12 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving SUZ12 protein from the WikiPathways Pathways 2024 dataset.