| Name | small vasohibin binding protein |
| Description | Enables microtubule binding activity and peptidase activator activity. Involved in axon development; proteolysis; and regulation of metallopeptidase activity. Acts upstream of or within negative regulation of endothelial cell migration; negative regulation of protein ubiquitination; and protein secretion. Located in apical part of cell. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies in hepatocellular carcinoma (HCC) and vascular endothelial cells have revealed that small vasohibin‐binding protein (SVBP) functions as a secretory chaperone for vasohibins, notably VASH2 and VASH1. In HCC models, SVBP cooperates with VASH2 to enhance its extracellular release, thereby promoting paracrine signaling that stimulates angiogenesis, tumor growth, and metastasis. Similarly, in endothelial cells, SVBP interacts directly with VASH1, increasing its solubility and inhibiting its ubiquitylation, which in turn augments its anti‐angiogenic activity by promoting effective secretion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural and biochemical investigations have further illuminated the role of SVBP in modulating vasohibin catalytic functions beyond angiogenesis. SVBP forms a stable heterodimer with vasohibins—particularly VASH1—which not only enhances their enzymatic activity responsible for the detyrosination of α-tubulin but is also critical for proper spindle function and chromosome segregation during mitosis. These studies have identified key residues and binding interfaces that underlie the recognition and processing of the C-terminal tyrosine of α-tubulin, underscoring the essential activator role of SVBP in both microtubule regulation and neuronal developmental processes such as axon specification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional genetic investigations have linked cellular pathways involving SVBP to broader human conditions, including autosomal recessive intellectual disability, although the precise mechanistic contribution of SVBP in these contexts remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X Xue, W Gao, B Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.177"}], "href": "https://doi.org/10.1038/onc.2012.177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22614011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22614011"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yasuhiro Suzuki, Miho Kobayashi, Hiroki Miyashita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.067538"}], "href": "https://doi.org/10.1242/jcs.067538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20736312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20736312"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tetsuya Kadonosono, Wanaporn Yimchuen, Takuya Tsubaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pro.3089"}], "href": "https://doi.org/10.1002/pro.3089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27879017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27879017"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shanhui Liao, Girish Rajendraprasad, Na Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41422-019-0187-y"}], "href": "https://doi.org/10.1038/s41422-019-0187-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31171830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31171830"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Na Wang, Christophe Bosc, Sung Ryul Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-019-0241-y"}], "href": "https://doi.org/10.1038/s41594-019-0241-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31235911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31235911"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Athanassios Adamopoulos, Lisa Landskron, Tatjana Heidebrecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-019-0254-6"}], "href": "https://doi.org/10.1038/s41594-019-0254-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31270470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31270470"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zafar Iqbal, Hasan Tawamie, Wei Ba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41436-018-0415-8"}], "href": "https://doi.org/10.1038/s41436-018-0415-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30607023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30607023"}]}]}]}
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| NCBI Gene ID | 374969 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SVBP has 1,251 functional associations with biological entities spanning 6 categories (disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 33 datasets.
Click the + buttons to view associations for SVBP from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SVBP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with SVBP protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with SVBP gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SVBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with SVBP gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of SVBP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing SVBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SVBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of SVBP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by SVBP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SVBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving SVBP gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving SVBP gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by SVBP gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by SVBP gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of SVBP gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of SVBP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of SVBP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of SVBP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| Kinase Library Tyrosine Kinome Atlas | kinases that phosphorylate SVBP protein from the Kinase Library Tyrosine Kinome Atlas dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by SVBP gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of SVBP gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving SVBP protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving SVBP protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SVBP gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SVBP gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SVBP gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of SVBP gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SVBP gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SVBP gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SVBP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SVBP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SVBP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
