SWAP70 Gene

HGNC Family	EF-hand domain containing, Pleckstrin homology domain containing (PLEKH), Minor histocompatibility antigens
Name	SWAP switching B-cell complex 70kDa subunit
Description	Enables cadherin binding activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane. Is active in postsynapse. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSWAP70 is a multifunctional signaling protein that regulates the actin cytoskeleton and participates in diverse cellular processes. It was first characterized as a B cell–specific component required for immunoglobulin class switch recombination, highlighting its role in lymphocyte function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Additionally, SWAP70 has been identified as a marker of a distinct subset of loose actin filament arrays that contribute to cell motility and membrane protrusion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn response to extracellular signals such as growth factor stimulation, SWAP70 is recruited to the plasma membrane where it directly binds non‐muscle F‑actin to drive membrane ruffling and actin remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Its recruitment and activity depend on binding to phosphoinositides embedded in the membrane, which triggers conformational alterations in its C‑terminal region and promotes localized activation of Rac1 at the leading edge."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSWAP70 also performs essential roles in immune cell function. In professional phagocytes such as dendritic cells and macrophages, it is specifically recruited to nascent phagosomes by binding phosphatidylinositol (3,4)‑bisphosphate, where it functions as a scaffold to tether and stabilize F‑actin rings around the phagosome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In eosinophils, SWAP70 regulates Rac1 activation and cytoskeletal rearrangements, which are necessary for proper adhesive interactions, cell polarization, and effective migration during inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in actin regulation, SWAP70 contributes to several other physiological and pathophysiological processes. It is highly expressed in migratory, invasive trophoblasts during the early stages of embryo implantation, suggesting a role in placentation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In tumor cells, SWAP70 oligomerizes to bundle F‑actin, modulating cell stiffness and promoting features associated with metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, in cardiac tissue under stress, SWAP70 interferes with TAK1-mediated signaling, thereby mitigating pathological hypertrophy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Finally, aberrant surface expression of SWAP70 in HIV‑1–infected cells points to its potential utility as a diagnostic marker of infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L Rapalus, Y Minegishi, A Lavoie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Immunol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/clim.2001.5116"}], "href": "https://doi.org/10.1006/clim.2001.5116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11726218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11726218"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pirta Hilpelä, Pia Oberbanscheidt, Penelope Hahne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SWAP-70 identifies a transitional subset of actin filaments in motile cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e03-01-0043"}], "href": "https://doi.org/10.1091/mbc.e03-01-0043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12925760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12925760"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sayoko Ihara, Tsutomu Oka, Yasuhisa Fukui "}, {"type": "b", "children": [{"type": "t", "text": "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.02767"}], "href": "https://doi.org/10.1242/jcs.02767"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16418221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16418221"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Naomi Tokuda, Katsuhisa Kawai, Young-Ho Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Membrane-induced alteration of the secondary structure in the SWAP-70 pleckstrin homology domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvr146"}], "href": "https://doi.org/10.1093/jb/mvr146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22247562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22247562"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nisha Kriplani, Rory R Duncan, Nicholas R Leslie "}, {"type": "b", "children": [{"type": "t", "text": "SWAP70 undergoes dynamic conformational regulation at the leading edge of migrating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.13326"}], "href": "https://doi.org/10.1002/1873-3468.13326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30636036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30636036"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Maksim V Baranov, Natalia H Revelo, Ilse Dingjan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.10.021"}], "href": "https://doi.org/10.1016/j.celrep.2016.10.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27806292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27806292"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Maksim V Baranov, Natalia H Revelo, Daniëlle R J Verboogen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SWAP70 is a universal GEF-like adaptor for tethering actin to phagosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Small GTPases (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21541248.2017.1328302"}], "href": "https://doi.org/10.1080/21541248.2017.1328302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28489960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28489960"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nooshin S Bahaie, M Reza Hosseinkhani, Xiao Na Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1102253"}], "href": "https://doi.org/10.4049/jimmunol.1102253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22210919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22210919"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jing Liu, Dong Li, Bin Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Histochem Cytochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1369/jhc.6A7151.2007"}], "href": "https://doi.org/10.1369/jhc.6A7151.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17371938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17371938"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Viktoria Betaneli, Rolf Jessberger "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of control of F-actin cortex architecture by SWAP-70."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.233064"}], "href": "https://doi.org/10.1242/jcs.233064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31932501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31932501"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chao-Yuan Chang, Glen Pearce, Viktoria Betaneli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The F-actin bundler SWAP-70 promotes tumor metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.202302307"}], "href": "https://doi.org/10.26508/lsa.202302307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38760173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38760173"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qiaofeng Qian, Fengjiao Hu, Wenjun Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.122.028628"}], "href": "https://doi.org/10.1161/JAHA.122.028628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36974751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36974751"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Noriaki Kimbara, Natsuki Dohi, Mizuyu Miyamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microbiol Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1348-0421.2006.tb03790.x"}], "href": "https://doi.org/10.1111/j.1348-0421.2006.tb03790.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16547421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16547421"}]}]}]}
Synonyms	SWAP-70, HSPC321
Proteins	SWP70_HUMAN
NCBI Gene ID	23075
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SWAP70 has 7,408 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for SWAP70 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SWAP70 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SWAP70 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SWAP70 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SWAP70 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SWAP70 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SWAP70 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SWAP70 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SWAP70 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SWAP70 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SWAP70 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SWAP70 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SWAP70 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SWAP70 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SWAP70 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SWAP70 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SWAP70 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SWAP70 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SWAP70 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SWAP70 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SWAP70 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SWAP70 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SWAP70 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SWAP70 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SWAP70 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SWAP70 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SWAP70 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SWAP70 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SWAP70 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SWAP70 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SWAP70 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SWAP70 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SWAP70 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SWAP70 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SWAP70 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SWAP70 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SWAP70 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SWAP70 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SWAP70 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SWAP70 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SWAP70 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SWAP70 from the GeneSigDB Published Gene Signatures dataset.