TACC1 Gene

Name	transforming, acidic coiled-coil containing protein 1
Description	This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTACC1, a member of the transforming acidic coiled‐coil protein family, has been implicated in tumorigenesis through multiple mechanisms. In a small subset of glioblastomas, for example, chromosomal translocations fuse FGFR kinase domains with TACC1 to create oncogenic FGFR–TACC fusion proteins that localize to the mitotic spindle poles, exhibit constitutive kinase activity, and promote chromosomal segregation defects, thereby driving aneuploidy and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, the human TACC1 gene is normally expressed in a cytoplasmic and perinuclear pattern, but its mRNA is frequently downregulated in various tumors (including breast cancers), a finding that may point to its participation in the regulation of mRNA processing through interactions with conserved small Sm-like proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In gastric cancers, several transcript variants of TACC1 have been identified—some with restricted expression patterns—and aberrant expression of these isoforms may serve as tumor markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, TACC1 can interact with other mitotic regulators such as ch-TOG and GAS41/NuBI1, suggesting that alterations in its binding partners might contribute to neoplastic transformation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while family-wide analysis of TACC proteins underscores their dual roles in both transformation and tumor suppression in a context-dependent manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its structural roles, TACC1 has emerged as an important prognostic marker in several cancers. Elevated TACC1 expression, together with a specific three-gene signature, has been correlated with shorter relapse-free survival in estrogen receptor–positive breast cancers resistant to anti-estrogen therapies such as tamoxifen and fulvestrant."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In gastric carcinoma, coexpression of TACC1 with HER2 is significantly associated with advanced TNM stage and lymph node metastasis, further identifying TACC1 as an independent prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In breast cancer cell models, knockdown of ErbB-2 (HER2) leads to an upregulation of TACC1 mRNA and protein levels and augments sensitivity to chemotherapeutic agents, thereby linking growth factor receptor signaling with TACC1 regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTACC1 also plays crucial roles during mitosis and cytokinesis. It localizes diffusely to the midzone spindle during anaphase and concentrates at the midbody during cell division, a dynamic pattern that underscores its participation in mitotic exit."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Its interaction with mitotic kinases is further exemplified by its association with Aurora B and Aurora C: TACC1 is found in complex with these kinases and is phosphorylated by Aurora C at specific serine residues, suggesting that its modification is key to proper cytokinesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In addition, novel gene fusions, such as FGFR1–TACC1 identified in uterine sarcomas, reinforce the notion that deregulated TACC1 moieties can serve as oncogenic drivers by aberrantly activating kinase pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these roles, TACC1 exhibits complex spatiotemporal and isoform-specific regulation that likely underlies its diverse functions in both development and disease. Detailed immunohistochemical analyses in embryonic tissues and mature human organs reveal that TACC1 can be localized to different subcellular compartments in a cell- and tissue-specific manner, thereby implying context-dependent functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In primary gastric cancers, TACC1 expression further substantiates its value as a marker of aggressive disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Moreover, given its role as a cofactor for nuclear hormone receptors, misregulation of TACC1 may contribute to oncogenesis via altered transcriptional control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, in non–small cell lung cancer, TACC1 is functionally linked to cell invasion, apoptosis, and chemoresistance through a ceRNA network involving long noncoding RNA LINC01140 and miR-4742-5p, further highlighting its emerging significance in therapeutic resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Devendra Singh, Joseph Minhow Chan, Pietro Zoppoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming fusions of FGFR and TACC genes in human glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1220834"}], "href": "https://doi.org/10.1126/science.1220834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22837387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22837387"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nathalie Conte, Emmanuelle Charafe-Jauffret, Bénédicte Delaval, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205658"}], "href": "https://doi.org/10.1038/sj.onc.1205658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12165861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12165861"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aija Line, Zane Slucka, Aivars Stengrevics, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered splicing pattern of TACC1 mRNA in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet Cytogenet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0165-4608(02)00607-6"}], "href": "https://doi.org/10.1016/s0165-4608(02"}, {"type": "t", "text": "00607-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12547166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12547166"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Brenda Lauffart, Scott J Howell, Jason E Tasch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/0264-6021:3630195"}], "href": "https://doi.org/10.1042/0264-6021:3630195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11903063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11903063"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Terence R Lappin, Robert N Mullan, J Peter Stewart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/1042819022386644"}], "href": "https://doi.org/10.1080/1042819022386644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12389629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12389629"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sandra E Ghayad, Julie A Vendrell, Ivan Bieche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/JME-08-0076"}], "href": "https://doi.org/10.1677/JME-08-0076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18984771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18984771"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jing Lv, Ya-sai Yao, Fei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0280-5"}], "href": "https://doi.org/10.1007/s12032-014-0280-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25297519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25297519"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jinyu Xiang, Wensheng Qiu, Xingang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Efficient downregulation of ErbB-2 induces TACC1 upregulation in breast cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2013.2253"}], "href": "https://doi.org/10.3892/or.2013.2253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23354013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23354013"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bénédicte Delaval, Alexia Ferrand, Nathalie Conte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aurora B -TACC1 protein complex in cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207593"}], "href": "https://doi.org/10.1038/sj.onc.1207593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15064709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15064709"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jean-Charles Gabillard, Salvatore Ulisse, Enke Baldini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.04.078"}], "href": "https://doi.org/10.1016/j.bbrc.2011.04.078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21531210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21531210"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kelly A Devereaux, Julianna J Weiel, Anne M Mills, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000001644"}], "href": "https://doi.org/10.1097/PAS.0000000000001644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33481389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33481389"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Brenda Lauffart, Anthony Dimatteo, Mary M Vaughan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Temporal and spatial expression of TACC1 in the mouse and human."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20724"}], "href": "https://doi.org/10.1002/dvdy.20724"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16496324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16496324"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Aiping Ding, Wenwen Zhao, Xiaoli Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of NPM, TFF3 and TACC1 on the prognosis of patients with primary gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0082136"}], "href": "https://doi.org/10.1371/journal.pone.0082136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24358147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24358147"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Romain Guyot, Séverine Vincent, Julie Bertin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2199-11-3"}], "href": "https://doi.org/10.1186/1471-2199-11-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20078863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20078863"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yanyun Wang, Man Li, Lin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01140 inhibits nonsmall cell lung cancer progression and cisplatin resistance through the miR-4742-5p/TACC1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23048"}], "href": "https://doi.org/10.1002/jbt.23048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35307914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35307914"}]}]}]}
Synonyms	GA55
Proteins	TACC1_HUMAN
NCBI Gene ID	6867
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TACC1 has 7,342 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for TACC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TACC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TACC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TACC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TACC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TACC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TACC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TACC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TACC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TACC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TACC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TACC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TACC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TACC1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TACC1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TACC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TACC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TACC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TACC1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TACC1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TACC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TACC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TACC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TACC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TACC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TACC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TACC1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TACC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TACC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TACC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TACC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TACC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TACC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TACC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TACC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TACC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TACC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TACC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TACC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TACC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TACC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TACC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.