TAOK1 Gene

Name	TAO kinase 1
Description	Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of MAPK cascade. Located in microtubule cytoskeleton and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTAOK1, a member of the Ste20 family of kinases, plays a central role in orchestrating diverse signaling pathways that control cell growth and stress responses. For instance, TAOK1 modulates the Salvador–Warts–Hippo pathway by phosphorylating components such as MST2, thereby repressing YAP‐mediated transcription and contributing to tumor suppression and the regulation of epithelial tissue proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In response to genotoxic stimuli, TAO kinases mediate p38 MAPK activation via ATM‐dependent phosphorylation, linking DNA damage to stress‐activated signaling cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In a genome‐wide association study, variants in a region upstream of TAOK1 were found to strongly correlate with mean platelet volume, suggesting that TAOK1 may contribute more broadly to cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTAOK1 is also a key regulator of cytoskeletal dynamics and mitotic progression. It facilitates proper chromosome congression and accurate kinetochore–microtubule attachments, a role underscored by studies showing that TAOK1 depletion leads to defective chromosome alignment"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Although an initial report linked TAOK1 to spindle checkpoint signaling through interactions with BubR1, subsequent analyses have indicated that such findings may be confounded by off‐target effects on Mad2 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In neurons, TAOK1 phosphorylates tau protein—targeting sites within the microtubule‐binding region—thus impacting microtubule stability and implicating TAOK1 in Alzheimer disease pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Its crosstalk with regulators of the cytoskeleton such as MARK and cofilin further supports a role in neuronal apoptosis and cytoskeletal organization"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and studies in cancer cells reveal that TAOK1 (along with TAOK2) localizes to centrosomes where its inhibition leads to multipolar spindle formation, prolonged mitosis, and ultimately cell death—a potential anticancer strategy in tumors with centrosome amplification"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to these cell‐intrinsic roles, TAOK1 is subject to regulation by noncoding RNAs and functions in diverse pathophysiological contexts. Extracellular vesicle–mediated delivery of miR‑381‑3p, for example, targets TAOK1 to suppress Hippo signaling and thereby promote chondrogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " TAOK1 also serves as a negative regulator of interleukin‑17 receptor signaling, limiting cytokine and chemokine expression during inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Genomic studies have identified de novo variants in TAOK1 in patients with neurodevelopmental disorders characterized by developmental delay, hypotonia, and intellectual disability, underscoring its importance in brain development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " In the liver, microRNA‑706–mediated suppression of TAOK1 protects against oxidative stress–induced fibrogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", while in diabetic nephropathy, dysregulation of circTAOK1 underscores its emerging role in metabolic disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Moreover, in acute myeloid leukemia, aberrant regulation of TAOK1 by a lncRNA–miRNA network (involving lncRNA C9ORF139 and miR‑24‑3p) promotes cell proliferation, migration, and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carole L C Poon, Jane I Lin, Xiaomeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2011.09.012"}], "href": "https://doi.org/10.1016/j.devcel.2011.09.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22075148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22075148"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Malavika Raman, Svetlana Earnest, Kai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAO kinases mediate activation of p38 in response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601668"}], "href": "https://doi.org/10.1038/sj.emboj.7601668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17396146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17396146"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christa Meisinger, Holger Prokisch, Christian Gieger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study identifies three loci associated with mean platelet volume."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2008.11.015"}], "href": "https://doi.org/10.1016/j.ajhg.2008.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19110211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19110211"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Viji M Draviam, Frank Stegmeier, Grzegorz Nalepa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1569"}], "href": "https://doi.org/10.1038/ncb1569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17417629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17417629"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Roshan L Shrestha, Naoka Tamura, Anna Fries, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Open Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1098/rsob.130108"}], "href": "https://doi.org/10.1098/rsob.130108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24898139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24898139"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nadja C Hübner, Lily Hui-Ching Wang, Manuel Kaulich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chromosoma (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00412-009-0244-2"}], "href": "https://doi.org/10.1007/s00412-009-0244-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19904549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19904549"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Frederick G Westhorpe, Maria A Diez, Mark D J Gurden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Re-evaluating the role of Tao1 in the spindle checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chromosoma (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00412-010-0261-1"}], "href": "https://doi.org/10.1007/s00412-010-0261-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20162290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20162290"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ignatius A Tavares, Dona Touma, Steven Lynham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.448183"}], "href": "https://doi.org/10.1074/jbc.M112.448183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23585562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23585562"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Cindy Johne, Dorthe Matenia, Xiao-Yu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-07-0730"}], "href": "https://doi.org/10.1091/mbc.e07-07-0730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18216281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18216281"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ceniz Zihni, Costas Mitsopoulos, Ignatius A Tavares, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513769200"}], "href": "https://doi.org/10.1074/jbc.M513769200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16407310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16407310"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chuay-Yeng Koo, Caterina Giacomini, Marta Reyes-Corral, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-17-0077"}], "href": "https://doi.org/10.1158/1535-7163.MCT-17-0077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28830982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28830982"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ming-Fang Wu, Shyang-Guang Wang "}, {"type": "b", "children": [{"type": "t", "text": "Human TAO kinase 1 induces apoptosis in SH-SY5Y cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellbi.2007.08.006"}], "href": "https://doi.org/10.1016/j.cellbi.2007.08.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17900936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17900936"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hui Jing, Xiaoyang Zhang, Kai Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-381-abundant small extracellular vesicles derived from kartogenin-preconditioned mesenchymal stem cells promote chondrogenesis of MSCs by targeting TAOK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomaterials (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biomaterials.2019.119682"}], "href": "https://doi.org/10.1016/j.biomaterials.2019.119682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31864017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31864017"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhaoru Zhang, Zhen Tang, Xianwei Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAOK1 negatively regulates IL-17-mediated signaling and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cmi.2017.158"}], "href": "https://doi.org/10.1038/cmi.2017.158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29400705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29400705"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Marija Dulovic-Mahlow, Joanne Trinh, Krishna Kumar Kandaswamy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De Novo Variants in TAOK1 Cause Neurodevelopmental Disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2019.05.005"}], "href": "https://doi.org/10.1016/j.ajhg.2019.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31230721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31230721"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jesse M Hunter, Lauren J Massingham, Kandamurugu Manickam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inherited and de novo variants extend the etiology of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TAOK1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-associated neurodevelopmental disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cold Spring Harb Mol Case Stud (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/mcs.a006180"}], "href": "https://doi.org/10.1101/mcs.a006180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35091509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35091509"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ruili Yin, Duo Guo, Shuxian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep37509"}], "href": "https://doi.org/10.1038/srep37509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27876854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27876854"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Bo Li, Guijiang Sun, Haibo Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Urol Nephrol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11255-022-03139-y"}], "href": "https://doi.org/10.1007/s11255-022-03139-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35142978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35142978"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Gang Du, Zhaochen Jiang, Tong Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.205730"}], "href": "https://doi.org/10.18632/aging.205730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38613803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38613803"}]}]}]}
Synonyms	HTAOK1, PSK-2, HKFC-B, PSK2, MARKK, KFC-B, MAP3K16
Proteins	TAOK1_HUMAN
NCBI Gene ID	57551
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TAOK1 has 10,151 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 138 datasets.

Click the + buttons to view associations for TAOK1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TAOK1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TAOK1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAOK1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAOK1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TAOK1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TAOK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TAOK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAOK1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TAOK1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAOK1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAOK1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TAOK1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAOK1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TAOK1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TAOK1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TAOK1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TAOK1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAOK1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TAOK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TAOK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TAOK1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TAOK1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TAOK1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TAOK1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TAOK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TAOK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TAOK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TAOK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TAOK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TAOK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAOK1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TAOK1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TAOK1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TAOK1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TAOK1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for TAOK1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TAOK1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TAOK1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TAOK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TAOK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TAOK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.