TASP1 Gene

Name	taspase, threonine aspartase, 1
Description	This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTaspase1 is an evolutionarily conserved threonine protease that initiates the site‐specific cleavage of key nuclear effectors, thereby controlling developmental gene programs. Notably, it processes the mixed-lineage leukemia (MLL) protein to generate heterodimeric fragments essential for maintaining HOX gene expression and it cleaves the TFIIA precursor to regulate its nuclear localization and transcriptional activity. Biochemical dissection has revealed a defined recognition consensus and spatial requirements for substrate processing, underscoring Taspase1’s critical role as a molecular switch during embryonic patterning and differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncogenesis, deregulation of Taspase1 activity plays a pivotal role in both tumor initiation and maintenance. Elevated levels of Taspase1 in cancer cells contribute to sustained proliferation, enhanced survival, and the stability of oncogenic fusion proteins such as AF4–MLL. Moreover, aberrant Taspase1 function is linked to the processing of cell cycle regulators and antiapoptotic mediators, while recently identified non-coding RNA species (e.g., circTASP1) derived from the TASP1 gene further fuel malignant progression. In experimental systems, attenuation of Taspase1 results in impaired proliferation and increased apoptosis, highlighting its potential as a promising target for anticancer therapeutics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent mechanistic and structure–function studies have further refined our understanding of Taspase1’s role in cellular regulation. Cell-based biosensor assays have delineated its substrate specificity and revealed that a long C-terminal helical region is indispensable for catalytic activity. Beyond substrate processing, Taspase1 has emerged as a multifunctional co-activator in hormone-induced transcription, linking proteolysis to epigenetic modulation through its cleavage of chromatin modifiers. These insights not only illuminate how Taspase1 orchestrates transcriptional programs but also provide a solid framework for the development of targeted inhibitors in cancer and developmental disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "James J-D Hsieh, Emily H-Y Cheng, Stanley J Korsmeyer "}, {"type": "b", "children": [{"type": "t", "text": "Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00816-x"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00816-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14636557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14636557"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huiqing Zhou, Salvatore Spicuglia, James J-D Hsieh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncleaved TFIIA is a substrate for taspase 1 and active in transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.7.2728-2735.2006"}], "href": "https://doi.org/10.1128/MCB.26.7.2728-2735.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16537915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16537915"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Barbora Malecová, Valentina S Caputo, Diane F Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transcription (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21541264.2015.1052178"}], "href": "https://doi.org/10.1080/21541264.2015.1052178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25996597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25996597"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Christian Schrenk, Verena Fetz, Cecilia Vallet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjx025"}], "href": "https://doi.org/10.1093/jmcb/mjx025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28992066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28992066"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "David Y Chen, Han Liu, Shugaku Takeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-0027"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-0027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20516119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20516119"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Carolin Bier, Rouven Hecht, Lena Kunst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0034142"}], "href": "https://doi.org/10.1371/journal.pone.0034142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22570686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22570686"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Samaneh Sabiani, Tim Geppert, Christian Engelbrecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2015.04.009"}], "href": "https://doi.org/10.1016/j.ebiom.2015.04.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26137584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26137584"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alena Gribko, Angelina Hahlbrock, Sebastian Strieth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disease-relevant signalling-pathways in head and neck cancer: Taspase1's proteolytic activity fine-tunes TFIIA function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-14814-x"}], "href": "https://doi.org/10.1038/s41598-017-14814-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29097782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29097782"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xue-Mei Wan, Xue-Lei Zhou, Yong-Jun Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TASP1 Promotes Proliferation and Migration in Gastric Cancer via EMT and AKT/P-AKT Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5521325"}], "href": "https://doi.org/10.1155/2021/5521325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34012990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34012990"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yuanyuan Lin, Yan Huang, Changda Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR-515-5p/HMGA2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16765"}], "href": "https://doi.org/10.1111/jcmm.16765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34197029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34197029"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Carolin Bier, Shirley K Knauer, Alexander Klapthor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-based analysis of structure-function activity of threonine aspartase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.161646"}], "href": "https://doi.org/10.1074/jbc.M110.161646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21084304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21084304"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nirupa Nagaratnam, Silvia L Delker, Rebecca Jernigan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights into the function of the catalytically active human Taspase1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2021.03.008"}], "href": "https://doi.org/10.1016/j.str.2021.03.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33784495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33784495"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lisa Oelschläger, Paul Stahl, Farnusch Kaschani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells12030363"}], "href": "https://doi.org/10.3390/cells12030363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36766705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36766705"}]}]}]}
Synonyms	DJ585I14.2, C20ORF13
Proteins	TASP1_HUMAN
NCBI Gene ID	55617
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TASP1 has 5,861 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for TASP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TASP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TASP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TASP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TASP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TASP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TASP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TASP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TASP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TASP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TASP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TASP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TASP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TASP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TASP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TASP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TASP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TASP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TASP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TASP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TASP1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TASP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TASP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TASP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TASP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TASP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TASP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TASP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TASP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with TASP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TASP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TASP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for TASP1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TASP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TASP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TASP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TASP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TASP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TASP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TASP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TASP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TASP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.