| Name | TBC1 domain family, member 24 |
| Description | This gene encodes a protein with a conserved domain, referred to as the TBC domain, characteristic of proteins which interact with GTPases. TBC domain proteins may serve as GTPase-activating proteins for a particular group of GTPases, the Rab (Ras-related proteins in brain) small GTPases which are involved in the regulation of membrane trafficking. Mutations in this gene are associated with familial infantile myoclonic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011] |
| Summary |
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Moreover, its capacity to modulate endosomal recycling and respond to oxidative stress is critical for maintaining proper synaptic connectivity and efficient neurotransmission."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic investigations into TBC1D24 have revealed a remarkably broad phenotypic spectrum. Pathogenic variants—including missense changes and compound heterozygous mutations—have been linked to diverse neurological disorders such as early-onset epileptic encephalopathies, familial infantile myoclonic epilepsy, and epilepsies with migrating focal seizures, as well as auditory defects encompassing both syndromic (e.g., DOORS syndrome) and nonsyndromic hearing loss (autosomal recessive DFNB86 and autosomal dominant DFNA65). Studies in families from various ethnic backgrounds have demonstrated that disruption of TBC1D24’s normal function perturbs neuronal circuit maturation, axonal specification, and synaptic transmission, thereby affecting both central nervous system and inner ear integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its pivotal roles in neurodevelopment, emerging evidence indicates that TBC1D24 function may extend to non‐neuronal contexts. For example, aberrant TBC1D24 expression has been implicated in breast carcinoma, where it promotes tumor cell proliferation, migration, and invasion via activation of the IGF1R/PI3K/AKT signaling pathway. These broader insights, coupled with detailed structural analyses and in vivo model studies, not only enhance our understanding of the molecular mechanisms underlying TBC1D24-associated disorders but also suggest potential avenues for therapeutic intervention that may target defects in vesicle trafficking and oxidative stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Antonio Falace, Fabia Filipello, Veronica La Padula, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2010.07.020"}], "href": "https://doi.org/10.1016/j.ajhg.2010.07.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20727515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20727515"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mark A Corbett, Melanie Bahlo, Lachlan Jolly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2010.08.001"}], "href": "https://doi.org/10.1016/j.ajhg.2010.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20797691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20797691"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kevin Lüthy, Davide Mei, Baptiste Fischer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awz175"}], "href": "https://doi.org/10.1093/brain/awz175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31257402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31257402"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mattéa J Finelli, Davide Aprile, Enrico Castroflorio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddy370"}], "href": "https://doi.org/10.1093/hmg/ddy370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30335140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30335140"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nguyen Thi Kim Nguyen, Norihiko Ohbayashi, Yasunori Kanaho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D24 regulates recycling of clathrin-independent cargo proteins mediated by tubular recycling endosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.05.007"}], "href": "https://doi.org/10.1016/j.bbrc.2020.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32475639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32475639"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Philippe M Campeau, Dalia Kasperaviciute, James T Lu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mutations in TBC1D24, a gene associated with epilepsy, also cause nonsyndromic deafness DFNB86."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.12.004"}], "href": "https://doi.org/10.1016/j.ajhg.2013.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24387994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24387994"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ayse Guven, Aslihan Tolun "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D24 truncating mutation resulting in severe neurodegeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2012-101313"}], "href": "https://doi.org/10.1136/jmedgenet-2012-101313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23343562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23343562"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Luping Zhang, Lingxiang Hu, Yongchuan Chai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A dominant mutation in the stereocilia-expressing gene TBC1D24 is a probable cause for nonsyndromic hearing impairment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22558"}], "href": "https://doi.org/10.1002/humu.22558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24729547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24729547"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jaeho Yoon, Yoo-Seok Hwang, Moonsup Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-05924-9"}], "href": "https://doi.org/10.1038/s41467-018-05924-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30154457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30154457"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Reymundo Lozano, Kristin Herman, Melanie Rothfuss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical intrafamilial variability in lethal familial neonatal seizure disorder caused by TBC1D24 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37933"}], "href": "https://doi.org/10.1002/ajmg.a.37933"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27541164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27541164"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Brian Appavu, Natalie Guido-Estrada, Kristin Lindstrom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Electroclinical phenotypes and outcomes in TBC1D24-related epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epileptic Disord (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1684/epd.2016.0849"}], "href": "https://doi.org/10.1684/epd.2016.0849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27502353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27502353"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Risa Tona, Ivan A Lopez, Cristina Fenollar-Ferrer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse Models of Human Pathogenic Variants of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TBC1D24"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Associated with Non-Syndromic Deafness DFNB86 and DFNA65 and Syndromes Involving Deafness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11101122"}], "href": "https://doi.org/10.3390/genes11101122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32987832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32987832"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Maria Rosaria De Filippo, Francesca Rizzo, Giovanna Marchese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of pathogenic mutations in six patients with MMPSI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epilepsy Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.eplepsyres.2013.11.007"}], "href": "https://doi.org/10.1016/j.eplepsyres.2013.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24315024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24315024"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jing Zhang, Jiaoyang Chen, Qi Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Infantile epilepsy with multifocal myoclonus caused by TBC1D24 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Seizure (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.seizure.2019.05.010"}], "href": "https://doi.org/10.1016/j.seizure.2019.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31112829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31112829"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dominika Oziębło, Marcin L Leja, Michal Lazniewski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D24 emerges as an important contributor to progressive postlingual dominant hearing loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-89645-y"}], "href": "https://doi.org/10.1038/s41598-021-89645-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33986365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33986365"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Qiaoyan Shao, Xiaorong Shi, Bihong Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D24-related familial infantile multifocal myoclonus: Description of a new Chinese pedigree with a 20 year follow up."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epilepsy Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.eplepsyres.2022.106923"}], "href": "https://doi.org/10.1016/j.eplepsyres.2022.106923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35413638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35413638"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "J Zhang, Y H Zhang, J Y Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Clinical phenotypes of TBC1D24 gene related epilepsy]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Er Ke Za Zhi (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.0578-1310.2018.09.007"}], "href": "https://doi.org/10.3760/cma.j.issn.0578-1310.2018.09.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30180405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30180405"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Na Zhang, Mei Hou, Shaochun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants in TBC1D24 associated with epilepsy and deafness: Report of two cases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jdn.10070"}], "href": "https://doi.org/10.1002/jdn.10070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33063868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33063868"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Peiliang Lei, Qingwen Zhu, Wenrong Dong "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of a novel TBC1D24 variation causing autosomal dominant non-syndromic hearing loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-55435-5"}], "href": "https://doi.org/10.1038/s41598-024-55435-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38413761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38413761"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiusheng Qu, Bin Zhao, Min Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of TBC1 Domain Family Member 24 (BC1D24) Inhibits Breast Carcinoma Growth via IGF1R/PI3K/AKT Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.906736"}], "href": "https://doi.org/10.12659/MSM.906736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29893377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29893377"}]}]}]}
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| Synonyms | DOORS, FIME, EIEE16, DFNA65, DFNB86, TLDC6 |
| Proteins | TBC24_HUMAN |
| NCBI Gene ID | 57465 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TBC1D24 has 5,616 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 103 datasets.
Click the + buttons to view associations for TBC1D24 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TBC1D24 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of TBC1D24 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TBC1D24 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TBC1D24 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TBC1D24 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of TBC1D24 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with TBC1D24 protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with TBC1D24 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBC1D24 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of TBC1D24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TBC1D24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations | phenotypes associated with TBC1D24 gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with TBC1D24 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TBC1D24 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing TBC1D24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing TBC1D24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with TBC1D24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TBC1D24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TBC1D24 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with TBC1D24 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with TBC1D24 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with TBC1D24 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by TBC1D24 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving TBC1D24 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving TBC1D24 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with TBC1D24 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with TBC1D24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TBC1D24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TBC1D24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with TBC1D24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TBC1D24 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBC1D24 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TBC1D24 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing TBC1D24 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with TBC1D24 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing TBC1D24 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of TBC1D24 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TBC1D24 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TBC1D24 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TBC1D24 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TBC1D24 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of TBC1D24 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving TBC1D24 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving TBC1D24 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TBC1D24 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing TBC1D24 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing TBC1D24 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing TBC1D24 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by TBC1D24 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TBC1D24 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TBC1D24 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TBC1D24 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of TBC1D24 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of TBC1D24 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of TBC1D24 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of TBC1D24 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with TBC1D24 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for TBC1D24 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TBC1D24 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TBC1D24 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TBC1D24 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TBC1D24 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of TBC1D24 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with TBC1D24 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of TBC1D24 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TBC1D24 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by TBC1D24 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TBC1D24 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of TBC1D24 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing TBC1D24 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with TBC1D24 gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for TBC1D24 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TBC1D24 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of TBC1D24 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving TBC1D24 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving TBC1D24 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving TBC1D24 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TBC1D24 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TBC1D24 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of TBC1D24 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TBC1D24 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TBC1D24 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TBC1D24 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TBC1D24 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TBC1D24 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with TBC1D24 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with TBC1D24 gene from the SynGO Synaptic Gene Annotations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of TBC1D24 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of TBC1D24 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TBC1D24 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of TBC1D24 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TBC1D24 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of TBC1D24 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TBC1D24 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with TBC1D24 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TBC1D24 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
