| Name | TBC1 domain family member 3E |
| Description | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstract (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "details the critical role of stereocilia rootlets in vertebrate hair cells, where the ankyrin‐repeat protein ANKRD24 is shown to concentrate at the insertion point. ANKRD24 forms an annular structure bridging the apical plasma membrane and the lower rootlet, where it binds TRIOBP‐5—a protein that bundles F‐actin within the rootlet. Together, these proteins ensure robust mechanical anchoring of the stereocilia, protect against overstimulation, and maintain auditory function over time.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, the abstract does not mention or investigate the function of TBC1D3E. As a result, no functional information regarding TBC1D3E can be derived from this study."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jocelyn F Krey, Chang Liu, Inna A Belyantseva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202109134"}], "href": "https://doi.org/10.1083/jcb.202109134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35175278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35175278"}]}]}]}
|
| NCBI Gene ID | 102723859 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TBC1D3E has 145 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 11 datasets.
Click the + buttons to view associations for TBC1D3E from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TBC1D3E gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TBC1D3E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by TBC1D3E gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of TBC1D3E gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TBC1D3E gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TBC1D3E gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TBC1D3E gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TBC1D3E gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TBC1D3E gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TBC1D3E protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving TBC1D3E protein from the WikiPathways Pathways 2024 dataset. | |