{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided offers an extensive overview of heterotrimeric G protein‐coupled receptor (GPCR) signaling pathways in diverse physiological contexts, ranging from calcium homeostasis and neural crest development to reproductive function and cardiac as well as pulmonary physiology. Several studies detail how receptors such as the extracellular Ca²⁺‐sensing receptor, mGluR1, endothelin receptors, GPR54, and others signal via Gαq/11 (and in some instances Gα12/13 or Gi/o) to coordinate downstream events such as PTH secretion, maternal behavior, synaptic plasticity, and osteoblast differentiation. These investigations highlight the precision with which GPCR signaling can regulate cellular adhesion, gene expression, and even hormonal feedback mechanisms, emphasizing the critical importance of the spatial and temporal regulation of G protein‐mediated pathways in health and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of these abstracts explicitly mention TBL3, a protein known in other contexts as Transducin Beta‑Like 3. While the studies comprehensively dissect the mechanisms and outcomes of GPCR–G protein signaling, they do not provide direct evidence regarding a role for TBL3 within these pathways. In the absence of defined data in these reports, any attribution of function to TBL3 must remain speculative. It is conceivable, given the intricate network of regulatory proteins that modulate GPCR signaling, that TBL3 could participate indirectly—for example, by acting as a scaffold or transcriptional co‐regulator in pathways downstream of G protein activation—but the provided evidence does not allow for any firm conclusions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these studies robustly document the activation and regulatory consequences of GPCR-mediated G protein signaling in numerous biological systems, they do not address a role for TBL3. Thus, any functional assignment of TBL3 within these signaling networks remains an open question. Future targeted investigations will be necessary to determine whether TBL3 interacts with components of G protein signaling cascades or modulates downstream transcriptional responses in a manner analogous to other regulatory mediators."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kathryn Ivey, Brandi Tyson, Pallavi Ukidwe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0012-1606(02)00097-0"}], "href": "https://doi.org/10.1016/s0012-1606(02"}, {"type": "t", "text": "00097-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12648486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12648486"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J Hartmann, R Blum, Y Kovalchuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4193-03.2004"}], "href": "https://doi.org/10.1523/JNEUROSCI.4193-03.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15175381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15175381"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nina Wettschureck, Alexandra Moers, Tuula Hamalainen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.18.8048-8054.2004"}], "href": "https://doi.org/10.1128/MCB.24.18.8048-8054.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15340067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15340067"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dagmara A Dettlaff-Swiercz, Nina Wettschureck, Alexandra Moers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2005.03.006"}], "href": "https://doi.org/10.1016/j.ydbio.2005.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15936338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15936338"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nina Wettschureck, EunAh Lee, Steven K Libutti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2006-0110"}], "href": "https://doi.org/10.1210/me.2006-0110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16988000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16988000"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Stefan Rieken, Susanne Herroeder, Antonia Sassmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605287200"}], "href": "https://doi.org/10.1074/jbc.M605287200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17023430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17023430"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Takahiro Sato, Yumiko Kawamura, Rieko Asai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.012708"}], "href": "https://doi.org/10.1242/dev.012708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18199583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18199583"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dieter Paul Hoyer, Sabine Grönke, Konrad F Frank, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-010-0454-1"}], "href": "https://doi.org/10.1007/s11010-010-0454-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20372981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20372981"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jacob M Szereszewski, Macarena Pampillo, Maryse R Ahow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012964"}], "href": "https://doi.org/10.1371/journal.pone.0012964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20886089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20886089"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Dieter Paul Hoyer, Yüksel Korkmaz, Sabine Grönke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Diabetol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1475-2840-9-93"}], "href": "https://doi.org/10.1186/1475-2840-9-93"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21190563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21190563"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sara Pahlavan, Martin Oberhofer, Benjamin Sauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvs162"}], "href": "https://doi.org/10.1093/cvr/cvs162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22562663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22562663"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Peter Siegert, Gudula Schmidt, Panagiotis Papatheodorou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003385"}], "href": "https://doi.org/10.1371/journal.ppat.1003385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23696743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23696743"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Vijayan Gangadharan, Deepitha Selvaraj, Martina Kurejova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pain (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pain.2013.08.019"}], "href": "https://doi.org/10.1016/j.pain.2013.08.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23973358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23973358"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rachel Mejia, Courtney Waite, Mario Ascoli "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Gq/11 in the mouse corpus luteum is required for parturition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2014-1324"}], "href": "https://doi.org/10.1210/me.2014-1324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25495873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25495873"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mazen Shihan, Kai-Hui Chan, Lutz Konrad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gnα11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2015.07.013"}], "href": "https://doi.org/10.1016/j.cellsig.2015.07.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26208885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26208885"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Courtney Waite, Rachel Mejia, Mario Ascoli "}, {"type": "b", "children": [{"type": "t", "text": "Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.115.136952"}], "href": "https://doi.org/10.1095/biolreprod.115.136952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26843449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26843449"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dimitrios Papadopoulos, Raimund Dietze, Mazen Shihan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnα11-Coupled Receptor in Sertoli Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0150143"}], "href": "https://doi.org/10.1371/journal.pone.0150143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26938869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26938869"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ariana Dela Cruz, Marc D Grynpas, Jane Mitchell "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Gα11 in Osteoblast Lineage Cells Suppresses the Osteoanabolic Response to Intermittent PTH and Exercise."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Calcif Tissue Int (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00223-016-0158-y"}], "href": "https://doi.org/10.1007/s00223-016-0158-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27300035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27300035"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Alison E John, Michael R Wilson, Anthony Habgood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aad5568"}], "href": "https://doi.org/10.1126/scisignal.aad5568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27811142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27811142"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kelly L Roszko, Ruiye Bi, Caroline M Gorvin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockin mouse with mutant G"}, {"type": "a", "children": [{"type": "t", "text": "b"}], "href": "b"}, {"type": "t", "text": "α"}, {"type": "a", "children": [{"type": "t", "text": "/b"}], "href": "/b"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "11"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.91079"}], "href": "https://doi.org/10.1172/jci.insight.91079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28194446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28194446"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Caroline M Gorvin, Fadil M Hannan, Sarah A Howles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G"}, {"type": "a", "children": [{"type": "t", "text": "b"}], "href": "b"}, {"type": "t", "text": "α"}, {"type": "a", "children": [{"type": "t", "text": "/b"}], "href": "/b"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "11"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " mutation in mice causes hypocalcemia rectifiable by calcilytic therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.91103"}], "href": "https://doi.org/10.1172/jci.insight.91103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28194447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28194447"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Amanda R Moore, Leili Ran, Youxin Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.01.081"}], "href": "https://doi.org/10.1016/j.celrep.2018.01.081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29490280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29490280"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jens Baron, Ainhoa Bilbao, Heide Hörtnagl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.14460"}], "href": "https://doi.org/10.1111/jnc.14460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29747224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29747224"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hannah M Stoveken, Stefano Zucca, Ikuo Masuho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The orphan receptor GPR139 signals via G"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "q/11"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " to oppose opioid effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.AC120.014770"}], "href": "https://doi.org/10.1074/jbc.AC120.014770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32576659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32576659"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "George A Stamatiades, Chirine Toufaily, Han Kyeol Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of Gαq/11 or Gαs Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endocr/bqab247"}], "href": "https://doi.org/10.1210/endocr/bqab247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34864945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34864945"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Birol Ay, Sajin Marcus Cyr, Kaitlin Klovdahl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gα11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.178993"}], "href": "https://doi.org/10.1172/jci.insight.178993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38530370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38530370"}]}]}]}