TBX1 Gene

HGNC Family T-boxes (TBX)
Name T-box 1
Description This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTBX1 encodes a T‐box transcription factor that plays a central role in early embryonic development. Initially characterized in patients with 22q11.2 deletion syndrome, TBX1 haploinsufficiency has been shown to contribute to abnormalities of the pharyngeal apparatus, craniofacial structures, and cardiovascular system. In animal models and human studies, both loss‐of‐function and gain‐of‐function mutations in TBX1 have been linked to DiGeorge/velocardiofacial syndrome phenotypes, while a novel nuclear localization signal and regulatory cis‐elements upstream of TBX1 have been defined, underscoring its complex transcriptional regulation. These observations, along with genetic screens that reveal rare TBX1 mutations in non‐deleted patients, highlight TBX1’s critical dosage‐sensitive role during early morphogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its developmental roles, TBX1 is crucial for the proper formation of the cardiac outflow tract and associated structures. In patients with congenital heart defects—including Tetralogy of Fallot, ventricular septal defects, and conotruncal abnormalities—various TBX1 coding and promoter mutations have been identified that either diminish or enhance its transcriptional activity. Such alterations are also associated with extracardiac manifestations including cleft palate and even inguinal hernia, suggesting that quantitative changes in TBX1 expression underlie multiple facets of the 22q11.2 deletion syndrome spectrum. Overall, these data reinforce TBX1’s pivotal role in orchestrating cardiovascular morphogenesis as well as related craniofacial and structural phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence further implicates TBX1 in the regulation of neurobehavioral traits and tumorigenesis. In 22q11.2 deletion syndrome, TBX1 haploinsufficiency has been associated with deficits in sensorimotor gating and cognitive dysfunction; however, common TBX1 polymorphisms do not appear to confer increased susceptibility to isolated psychiatric disorders. In addition, TBX1 modulates angiogenic processes in the brain by regulating key endothelial genes, while in adult tissues its deregulated expression influences cell cycle progression in parathyroid cells and exerts tumor‐suppressive effects in cervical and thyroid cancers. Moreover, recent data indicate that TBX1 may affect cellular migration in basal cell carcinoma and colorectal cancer cells and even interact with homeodomain proteins to regulate TGF‐β/BMP‐dependent renal morphogenesis. These multifaceted roles highlight TBX1 as a central regulatory node whose altered expression or function can impact a wide array of pathophysiological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "20", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Richard Paylor, Beate Glaser, Annalisa Mupo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0600206103"}], "href": "https://doi.org/10.1073/pnas.0600206103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16684884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16684884"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hiroyuki Yamagishi, Jun Maeda, Tonghuan Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1048903"}], "href": "https://doi.org/10.1101/gad.1048903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12533514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12533514"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christiane Zweier, Heinrich Sticht, Inci Aydin-Yaylagül, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/511993"}], "href": "https://doi.org/10.1086/511993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17273972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17273972"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jason Z Stoller, Jonathan A Epstein "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddi081"}], "href": "https://doi.org/10.1093/hmg/ddi081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15703190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15703190"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tsutomu Ogata, Tetsuya Niihori, Noriko Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBX1 mutation identified by exome sequencing in a Japanese family with 22q11.2 deletion syndrome-like craniofacial features and hypocalcemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0091598"}], "href": "https://doi.org/10.1371/journal.pone.0091598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24637876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24637876"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Maria Zoupa, Maisa Seppala, Thimios Mitsiadis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx1 is expressed at multiple sites of epithelial-mesenchymal interaction during early development of the facial complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1387/ijdb.052116mz"}], "href": "https://doi.org/10.1387/ijdb.052116mz"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16586352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16586352"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marie-Antoinette Voelckel, Lydie Girardot, Bernard Giusiano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allelic variations at the haploid TBX1 locus do not influence the cardiac phenotype in cases of 22q11 microdeletion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.anngen.2004.04.002"}], "href": "https://doi.org/10.1016/j.anngen.2004.04.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15337468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15337468"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "T Y Tan, C T Gordon, D J Amor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Developmental perspectives on copy number abnormalities of the 22q11.2 region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-0004.2010.01456.x"}], "href": "https://doi.org/10.1111/j.1399-0004.2010.01456.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20497193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20497193"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xuechao Jiang, Tingting Li, Sijie Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in a cis-regulatory element of TBX1 in conotruncal heart defect patients impair GATA6-mediated transactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orphanet J Rare Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13023-021-01981-4"}], "href": "https://doi.org/10.1186/s13023-021-01981-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34332615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34332615"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Helen R Griffin, Ana Töpf, Elise Glen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic survey of variants in TBX1 in non-syndromic tetralogy of Fallot identifies a novel 57 base pair deletion that reduces transcriptional activity but finds no evidence for association with common variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Heart (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/hrt.2010.200121"}], "href": "https://doi.org/10.1136/hrt.2010.200121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20937753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20937753"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tingwei Guo, Donna McDonald-McGinn, Anna Blonska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genotype and cardiovascular phenotype correlations with TBX1 in 1,022 velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21568"}], "href": "https://doi.org/10.1002/humu.21568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21796729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21796729"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yun Pan, Zha-Gen Wang, Xing-Yuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel TBX1 Loss-of-Function Mutation Associated with Congenital Heart Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Cardiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00246-015-1173-x"}], "href": "https://doi.org/10.1007/s00246-015-1173-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25860641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25860641"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yue-Juan Xu, Sun Chen, Jian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel TBX1 loss-of-function mutation causes isolated conotruncal heart defects in Chinese patients without 22q11.2 deletion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-15-78"}], "href": "https://doi.org/10.1186/1471-2350-15-78"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24998776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24998776"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sean B Herman, Tingwei Guo, Donna M McDonald McGinn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overt cleft palate phenotype and TBX1 genotype correlations in velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.35512"}], "href": "https://doi.org/10.1002/ajmg.a.35512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23034814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23034814"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Haihua Wang, Dongfeng Chen, Liming Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of the TBX1 gene promoter in ventricular septal defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-012-1397-5"}], "href": "https://doi.org/10.1007/s11010-012-1397-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22801995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22801995"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Adolfo Aguayo-Gómez, Jazmín Arteaga-Vázquez, Yevgeniya Svyryd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Copy Number Variations in Isolated Tetralogy of Fallot."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Cardiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00246-015-1210-9"}], "href": "https://doi.org/10.1007/s00246-015-1210-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26036351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26036351"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Amel Jaouadi, Mouna Tabebi, Fatma Abdelhedi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel TBX1 missense mutation in patients with syndromic congenital heart defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.03.190"}], "href": "https://doi.org/10.1016/j.bbrc.2018.03.190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29596833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29596833"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yu Zhang, Qingluan Han, Chunyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of the TBX1 gene promoter in indirect inguinal hernia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2013.11.012"}], "href": "https://doi.org/10.1016/j.gene.2013.11.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24295890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24295890"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Feryal Cabuk, Halil G Karabulut, Timur Tuncali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBX1 gene mutation screening in patients with non-syndromic Fallot tetralogy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Turk J Pediatr (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17479646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17479646"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Laura Torres-Juan, Jordi Rosell, Montse Morla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in TBX1 genocopy the 22q11.2 deletion and duplication syndromes: a new susceptibility factor for mental retardation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ejhg.5201819"}], "href": "https://doi.org/10.1038/sj.ejhg.5201819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17377518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17377518"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sara Cioffi, Stefania Martucciello, Filomena Gabriella Fulcoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx1 regulates brain vascularization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddt400"}], "href": "https://doi.org/10.1093/hmg/ddt400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23945394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23945394"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Na Wang, Yiqi Li, Jing Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBX1 Functions as a Tumor Suppressor in Thyroid Cancer Through Inhibiting the Activities of the PI3K/AKT and MAPK/ERK Pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2018.0312"}], "href": "https://doi.org/10.1089/thy.2018.0312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30543152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30543152"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Chiara Verdelli, Laura Avagliano, Vito Guarnieri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression, function, and regulation of the embryonic transcription factor TBX1 in parathyroid tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2017.88"}], "href": "https://doi.org/10.1038/labinvest.2017.88"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28920943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28920943"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Haixia Liu, Mei Song, Xiaoyan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1880732"}], "href": "https://doi.org/10.1080/21655979.2021.1880732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33557670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33557670"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yu-Zheng Ge, Zheng Xu, Lu-Wei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathway analysis of genome-wide association study on serum prostate-specific antigen levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2014.08.044"}], "href": "https://doi.org/10.1016/j.gene.2014.08.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25168891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25168891"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yu Fu, Fei Li, Diana Yue Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between Tbx1 and Hoxd10 and connection with TGFβ-BMP signal pathway during kidney development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2012.06.069"}], "href": "https://doi.org/10.1016/j.gene.2012.06.069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22842189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22842189"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Birgit H Funke, Todd Lencz, Christine T Finn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of TBX1 variation in patients with psychotic and affective disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2119/2006–00119.Funke"}], "href": "https://doi.org/10.2119/2006–00119.Funke"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17622328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17622328"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Gang Ma, YongYong Shi, Wei Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2007.07.055"}], "href": "https://doi.org/10.1016/j.neulet.2007.07.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17850965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17850965"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Cinzia Caprio, Silvia Varricchio, Marchesa Bilio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBX1 and Basal Cell Carcinoma: Expression and Interactions with "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Gli2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Dvl2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21020607"}], "href": "https://doi.org/10.3390/ijms21020607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31963474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31963474"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Changfeng Li, Dayong Ding, Yongjian Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑3651 promotes colorectal cancer cell proliferation through directly repressing T‑box transcription factor 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2020.4458"}], "href": "https://doi.org/10.3892/ijmm.2020.4458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31922246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31922246"}]}]}]}
Synonyms VCFS, TBX1C, CAFS, CTHM, DGCR, TGA
Proteins TBX1_HUMAN
NCBI Gene ID 6899
API
Download Associations
Predicted Functions View TBX1's ARCHS4 Predicted Functions.
Co-expressed Genes View TBX1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View TBX1's ARCHS4 Predicted Functions.

Functional Associations

TBX1 has 7,737 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for TBX1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TBX1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of TBX1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TBX1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of TBX1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of TBX1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of TBX1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of TBX1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of TBX1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with TBX1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBX1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of TBX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of TBX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
ClinVar Gene-Phenotype Associations phenotypes associated with TBX1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of TBX1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing TBX1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing TBX1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with TBX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with TBX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of TBX1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with TBX1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with TBX1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with TBX1 gene/protein from the curated CTD Gene-Disease Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by TBX1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Curated Gene-Disease Association Evidence Scores diseases involving TBX1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving TBX1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with TBX1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with TBX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with TBX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with TBX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with TBX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TBX1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBX1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of TBX1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing TBX1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with TBX1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with TBX1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of TBX1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with TBX1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing TBX1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of TBX1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of TBX1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of TBX1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of TBX1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of TBX1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of TBX1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving TBX1 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving TBX1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving TBX1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing TBX1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing TBX1 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing TBX1 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by TBX1 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by TBX1 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by TBX1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of TBX1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of TBX1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of TBX1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of TBX1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWASdb SNP-Disease Associations diseases associated with TBX1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with TBX1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of TBX1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of TBX1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of TBX1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of TBX1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of TBX1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPO Gene-Disease Associations phenotypes associated with TBX1 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
HuBMAP ASCT+B Annotations cell types associated with TBX1 gene from the HuBMAP ASCT+B dataset.
HuBMAP ASCT+B Augmented with RNA-seq Coexpression cell types associated with TBX1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
HuBMAP Azimuth Cell Type Annotations cell types associated with TBX1 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with TBX1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by TBX1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for TBX1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of TBX1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of TBX1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of TBX1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of TBX1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of TBX1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LOCATE Curated Protein Localization Annotations cellular components containing TBX1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain TBX1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by TBX1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting TBX1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of TBX1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by TBX1 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for TBX1 from the MSigDB Cancer Gene Co-expression Modules dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of TBX1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
OMIM Gene-Disease Associations phenotypes associated with TBX1 gene from the curated OMIM Gene-Disease Associations dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for TBX1 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of TBX1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of TBX1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving TBX1 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving TBX1 protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2024 pathways involving TBX1 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of TBX1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of TBX1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of TBX1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of TBX1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TBX1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of TBX1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of TBX1 gene from the RummaGEO Gene Perturbation Signatures dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of TBX1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of TBX1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of TBX1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of TBX1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of TBX1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of TBX1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of TBX1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with TBX1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with TBX1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving TBX1 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving TBX1 protein from the WikiPathways Pathways 2024 dataset.