TBX3 Gene

HGNC Family	T-boxes (TBX)
Name	T-box 3
Description	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTBX3 is a member of the T‐box family of transcription factors with highly influential roles in embryonic patterning and organogenesis. It is essential for establishing the fate and function of pacemaker and conduction system cells in the developing heart, where it represses working myocardial gene expression to localize pacemaker activity. In addition, TBX3 participates in the proper formation of limbs, musculoskeletal attachments, and mammary glands, and its haploinsufficiency is linked to ulnar–mammary syndrome. Its ability to drive differentiation toward pacemaker‐like cells from pluripotent sources further underscores its central role in cardiac and musculoskeletal development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOverexpression or deregulated activity of TBX3 is strongly associated with the progression of multiple cancers—including breast cancer, melanoma, gastric cancer, and head and neck carcinoma—by promoting oncogenic processes. Functioning largely as a transcriptional repressor, TBX3 targets tumor suppressor genes (for example, p14^(ARF)) and key cell adhesion molecules such as E‐cadherin. These actions contribute to enhanced proliferation, the onset of epithelial–mesenchymal transition (EMT), increased migratory capacity, and invasiveness. TBX3 is also functionally integrated into signaling pathways such as transforming growth factor–β (TGF‐β) and AKT1, which appear to modulate its capacity to drive the transition from pre‐invasive lesions to bulk invasive tumors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its developmental and oncogenic roles, TBX3 is subject to intricate regulatory control at multiple levels. Its expression and activity are modulated via extracellular signals such as phorbol esters and TGF‐β, and fine-tuned by microRNAs—for instance, miR-206 acts as a repressor—to ensure context‐dependent outputs. Moreover, TBX3 forms complexes with histone deacetylases and RNA splicing factors, thereby influencing alternative splicing and chromatin remodeling of its target genes. This multi‐layered regulation extends its influence to areas such as osteogenic differentiation of mesenchymal stem cells and even the regulation of viral gene expression, underscoring the broad impact of TBX3 in both normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vasco Meneghini, Sylvie Odent, Natalia Platonova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2005.04.021"}], "href": "https://doi.org/10.1016/j.ejmg.2005.04.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16530712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16530712"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mathilda T M Mommersteeg, Willem M H Hoogaars, Owen W J Prall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular pathway for the localized formation of the sinoatrial node."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000258019.74591.b3"}], "href": "https://doi.org/10.1161/01.RES.0000258019.74591.b3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17234970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17234970"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mary P Colasanto, Shai Eyal, Payam Mohassel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.025874"}], "href": "https://doi.org/10.1242/dmm.025874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27491074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27491074"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hongyi Zhao, Fengyuan Wang, Wei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2020.110612"}], "href": "https://doi.org/10.1016/j.biopha.2020.110612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32771895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32771895"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Merel E Lingbeek, Jacqueline J L Jacobs, Maarten van Lohuizen "}, {"type": "b", "children": [{"type": "t", "text": "The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200403200"}], "href": "https://doi.org/10.1074/jbc.M200403200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12000749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12000749"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mercedes Rodriguez, Ewa Aladowicz, Luisa Lanfrancone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx3 represses E-cadherin expression and enhances melanoma invasiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-0301"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-0301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18829543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18829543"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Will Yarosh, Tomasa Barrientos, Taraneh Esmailpour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-5012"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-5012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18245468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18245468"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Durmus Burgucu, Kenan Guney, Duygu Sahinturk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-12-481"}], "href": "https://doi.org/10.1186/1471-2407-12-481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23082988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23082988"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jarod Li, Marc S Weinberg, Luiz Zerbini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-05-0273"}], "href": "https://doi.org/10.1091/mbc.E13-05-0273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24025717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24025717"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jade Peres, Sharon Prince "}, {"type": "b", "children": [{"type": "t", "text": "The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-12-117"}], "href": "https://doi.org/10.1186/1476-4598-12-117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24098938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24098938"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Willemien Beukers, Raju Kandimalla, Roy G Masius, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stratification based on methylation of TBX2 and TBX3 into three molecular grades predicts progression in patients with pTa-bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2014.145"}], "href": "https://doi.org/10.1038/modpathol.2014.145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25394776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25394776"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Milica Krstic, Connor D Macmillan, Hon S Leong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2697-z"}], "href": "https://doi.org/10.1186/s12885-016-2697-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27553211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27553211"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhi-Feng Miao, Xing-Yu Liu, Hui-Mian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virchows Arch (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00428-016-2007-9"}], "href": "https://doi.org/10.1007/s00428-016-2007-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27553355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27553355"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rehana Omar, Aretha Cooper, Hapiloe Mabaruti Maranyane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.06.004"}], "href": "https://doi.org/10.1016/j.canlet.2019.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31202624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31202624"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hee Sook Lee, Hyun Hwa Cho, Hoe Kyu Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tbx3, a transcriptional factor, involves in proliferation and osteogenic differentiation of human adipose stromal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-006-9306-4"}], "href": "https://doi.org/10.1007/s11010-006-9306-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16955224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16955224"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jin-fang Zhang, Ming-liang He, Qi Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Integr Cancer Ther (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1534735410373921"}], "href": "https://doi.org/10.1177/1534735410373921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20702496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20702496"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shaheen Mowla, Romaney Pinnock, Virna D Leaner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20100886"}], "href": "https://doi.org/10.1042/BJ20100886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20942798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20942798"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "James Smith, Shaheen Mowla, Sharon Prince "}, {"type": "b", "children": [{"type": "t", "text": "Basal transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2011.07.013"}], "href": "https://doi.org/10.1016/j.gene.2011.07.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21784138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21784138"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Marc A Schneider, Konstanze D Scheffer, Timo Bund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01803-12"}], "href": "https://doi.org/10.1128/JVI.01803-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23388722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23388722"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Pavan Kumar P, Sarah Franklin, Uchenna Emechebe, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2016.73"}], "href": "https://doi.org/10.1038/bjc.2016.73"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27100732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27100732"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jarod Li, Deeya Ballim, Mercedes Rodriguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The anti-proliferative function of the TGF-β1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.596411"}], "href": "https://doi.org/10.1074/jbc.M114.596411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25371204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25371204"}]}]}]}
Synonyms	UMS, XHL, TBX3-ISO
Proteins	TBX3_HUMAN
NCBI Gene ID	6926
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TBX3 has 10,599 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for TBX3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TBX3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TBX3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TBX3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TBX3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TBX3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TBX3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TBX3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TBX3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TBX3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TBX3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TBX3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TBX3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TBX3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TBX3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBX3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TBX3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TBX3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TBX3 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TBX3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TBX3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TBX3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TBX3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TBX3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TBX3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TBX3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TBX3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TBX3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TBX3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TBX3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TBX3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TBX3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TBX3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TBX3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TBX3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TBX3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TBX3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TBX3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBX3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TBX3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TBX3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TBX3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.