| Name | t-complex 11 family, X-linked 2 |
| Description | Predicted to be involved in protein kinase A signaling and regulation of sperm capacitation. Predicted to be active in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nKv channel interacting proteins (KChIPs), including isoforms such as KChIP4a, are calcium‐binding proteins that associate with the pore‐forming Kv4 subunits. These interactions serve to fine‐tune neuronal excitability by modulating channel gating, inactivation kinetics, and surface trafficking. Moreover, distinct KChIP isoforms exhibit regionally specific expression in the brain, suggesting they play tailored roles in regulating the distribution and function of Kv4 channels in different neuronal populations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural and biochemical studies have revealed that specialized domains in KChIP proteins critically influence Kv4 channel behavior. For instance, the unique N-terminal region of KChIP4a appears to act as an auto-inhibitory element that suppresses rapid channel inactivation while, paradoxically, its conserved C-terminal core facilitates channel tetrameric assembly and surface expression. In addition, phosphorylation of specific sites on Kv4.2—mediated by local A-kinase anchoring proteins (AKAPs)—is required for the KChIP4a-dependent stabilization and enhanced membrane delivery of the channel complexes. These findings underscore a complex interplay between discrete protein domains and post-translational modifications that ultimately regulate channel gating and trafficking."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond their roles in modulating neuronal excitability, alterations in the function of Kv channel interacting proteins may extend to broader physiological and pathophysiological contexts. Integrated genetic analyses in mice and humans have implicated the homologous KCNIP4 gene in conditions such as asthma, suggesting that dysregulation of Kv4 channel trafficking or gating could influence airway hyperresponsiveness and disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui Xiong, Imre Kovacs, Zhuohua Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Differential distribution of KChIPs mRNAs in adult mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Mol Brain Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molbrainres.2004.06.024"}], "href": "https://doi.org/10.1016/j.molbrainres.2004.06.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15363885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15363885"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jochen Schwenk, Gerd Zolles, Nikolaos G Kandias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800976200"}], "href": "https://doi.org/10.1074/jbc.M800976200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18458082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18458082"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ping Liang, Huayi Wang, Hao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807704200"}], "href": "https://doi.org/10.1074/jbc.M807704200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19109250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19109250"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lin Lin, Wei Sun, Andrew M Wikenheiser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2009.12.005"}], "href": "https://doi.org/10.1016/j.mcn.2009.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20045463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20045463"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ping Liang, Hao Chen, Yuanyuan Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biophys J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bpj.2010.03.044"}], "href": "https://doi.org/10.1016/j.bpj.2010.03.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20550899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20550899"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Blanca E Himes, Keith Sheppard, Annerose Berndt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0056179"}], "href": "https://doi.org/10.1371/journal.pone.0056179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23457522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23457522"}]}]}]}
|
| Proteins | T11X2_HUMAN |
| NCBI Gene ID | 100996648 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
TCP11X2 has 753 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 34 datasets.
Click the + buttons to view associations for TCP11X2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of TCP11X2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TCP11X2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TCP11X2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TCP11X2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of TCP11X2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TCP11X2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing TCP11X2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TCP11X2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TCP11X2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TCP11X2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TCP11X2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TCP11X2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TCP11X2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing TCP11X2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing TCP11X2 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of TCP11X2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TCP11X2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TCP11X2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of TCP11X2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TCP11X2 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing TCP11X2 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of TCP11X2 gene from the GTEx eQTL 2025 dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of TCP11X2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of TCP11X2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for TCP11X2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TCP11X2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TCP11X2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of TCP11X2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TCP11X2 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TCP11X2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TCP11X2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TCP11X2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TCP11X2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TCP11X2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
