TEC Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH), SH2 domain containing
Name	tec protein tyrosine kinase
Description	The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMultiple studies have established a critical role for TEC in immune cell signaling. In B lymphocytes, TEC functions in tandem with Bruton's tyrosine kinase (Btk) to promote site‐specific phosphorylation of phospholipase Cγ2 (PLCγ2) within the SH2‐SH3 linker region, thereby sustaining calcium mobilization following antigen receptor engagement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Complementary work in lymphocytes has shown that although TEC is expressed at relatively low basal levels in T and B cells, its expression is upregulated upon activation; overexpression of TEC is sufficient to induce PLCγ phosphorylation and activate nuclear factor of activated T cells (NFAT) transcriptional responses, while in T-lymphoid cells, TEC overexpression can even suppress CD25 expression following T-cell receptor ligation, indicating a role in fine-tuning immune activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTEC activity is also tightly controlled within immune cells. TEC family kinases exhibit selective transphosphorylation of their own SH3 domains – for example, phosphorylation of a conserved tyrosine residue in TEC (Y206) – which likely modulates their substrate interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, TEC is a downstream effector of phosphatidylinositol 3-kinase (PI3K) activity, and its membrane localization and subsequent signaling are negatively regulated by the inositol 5′-phosphatases SHIP1 and SHIP2, which deplete the local PtdIns 3,4,5-P3 pool."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOutside of adaptive immunity, TEC plays important roles in innate and inflammatory responses. In human neutrophils, TEC is rapidly activated by chemotactic factors such as fMet-Leu-Phe, as evidenced by its translocation to membrane fractions and increased tyrosine phosphorylation; TEC activation in these cells links G protein-coupled receptor stimulation to downstream tyrosine kinase cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, TEC activation in LPS-stimulated neutrophils contributes to the phosphorylation of specific MAPKs – notably JNK – and enhances the production of pro-inflammatory cytokines such as monocyte chemoattractant protein-1 (MCP-1) and others."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Similarly, in human alveolar epithelial cells, TEC mediates lipopolysaccharide-induced interleukin-8 (IL-8) production via both p38 MAPK and ERK MAPK signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTEC’s regulatory functions extend into the realm of unconventional protein secretion and oncogenesis. TEC directly associates with fibroblast growth factor 2 (FGF2) and phosphorylates it at a critical tyrosine residue (Tyr82), a modification essential for FGF2’s translocation across the plasma membrane – a process vital both for tumor-induced angiogenesis and for maintenance of human pluripotent stem cell self-renewal."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": " In parallel, aberrant TEC activity is implicated in carcinogenesis through fusion proteins; in extraskeletal myxoid chondrosarcoma, fusion of the TFG (TRK-fused gene) N-terminal domain to the TEC gene yields a chimeric protein with enhanced transactivation potential, suggesting that altered TEC signaling contributes to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": " Furthermore, in hepatocellular carcinoma (HCC), TEC-mediated phosphorylation of PLK4 at tyrosine 86 stabilizes PLK4 protein and promotes cell migration and invasion, correlating with poorer clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLastly, while studies using a bimolecular fluorescence complementation assay revealed that several Tec family kinases (such as Btk, Bmx, and Itk) interact with the HIV-1 Nef protein, TEC itself does not appear to directly interact with Nef, underscoring the functional specificity within the TEC kinase family."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lisa A Humphries, Carol Dangelmaier, Karen Sommer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311985200"}], "href": "https://doi.org/10.1074/jbc.M311985200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15184383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15184383"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael G Tomlinson, Lawrence P Kane, Jennifer Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.6.2455-2466.2004"}], "href": "https://doi.org/10.1128/MCB.24.6.2455-2466.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14993283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14993283"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kentaro Susaki, Akira Kitanaka, Hiroaki Dobashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Lett (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imlet.2009.10.009"}], "href": "https://doi.org/10.1016/j.imlet.2009.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19883687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19883687"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Beston F Nore, Pekka T Mattsson, Per Antonsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1570-9639(02)00524-1"}], "href": "https://doi.org/10.1016/s1570-9639(02"}, {"type": "t", "text": "00524-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12573241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12573241"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michael G Tomlinson, Victoria L Heath, Chris W Turck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408141200"}], "href": "https://doi.org/10.1074/jbc.M408141200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15492005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15492005"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Geneviève Lachance, Sylvain Levasseur, Paul H Naccache "}, {"type": "b", "children": [{"type": "t", "text": "Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201903200"}], "href": "https://doi.org/10.1074/jbc.M201903200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11940595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11940595"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Oana Popa-Nita, Louis Marois, Guillaume Paré, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal-induced neutrophil activation: X. Proinflammatory role of the tyrosine kinase Tec."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.23801"}], "href": "https://doi.org/10.1002/art.23801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18512796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18512796"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rachel L Zemans, Patrick G Arndt "}, {"type": "b", "children": [{"type": "t", "text": "Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellimm.2009.03.017"}], "href": "https://doi.org/10.1016/j.cellimm.2009.03.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19393603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19393603"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Y Wang, Y Hu, F Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Role and mechanism of nonreceptor tyrosine kinase Tec in endotoxin/lipopolysaccharide-induced interleukin-8 production in human alveolar epithelial cells A549]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Shao Shang Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1009-2587.2019.08.005"}], "href": "https://doi.org/10.3760/cma.j.issn.1009-2587.2019.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31474037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31474037"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Antje D Ebert, Mareike Laussmann, Sabine Wegehingel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2010.01059.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2010.01059.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20230531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20230531"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Giuseppe La Venuta, Sabine Wegehingel, Peter Sehr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.729384"}], "href": "https://doi.org/10.1074/jbc.M116.729384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27382052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27382052"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tereza Vanova, Zaneta Konecna, Zuzana Zbonakova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.2660"}], "href": "https://doi.org/10.1002/stem.2660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28631381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28631381"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Annie Maltais, Christine Filion, Yves Labelle "}, {"type": "b", "children": [{"type": "t", "text": "The AF2 domain of the orphan nuclear receptor TEC is essential for the transcriptional activity of the oncogenic fusion protein EWS/TEC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0304-3835(02)00104-0"}], "href": "https://doi.org/10.1016/s0304-3835(02"}, {"type": "t", "text": "00104-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12049818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12049818"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bobae Lim, Hee Jung Jun, Ah-young Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgs164"}], "href": "https://doi.org/10.1093/carcin/bgs164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22581839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22581839"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "B Zimmermann, F Girard, Z Mészàr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2013.06.004"}], "href": "https://doi.org/10.1016/j.brainres.2013.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23850650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23850650"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chuan Chen, Ge Wang, Zhi-Min Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[The expression of Tec and the level of its phosphorylation in primary hepatic carcinomas]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Gan Zang Bing Za Zhi (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18171525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18171525"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sai-Fung Yeung, Yuan Zhou, Wenjun Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TEC kinase stabilizes PLK4 to promote liver cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.08.038"}], "href": "https://doi.org/10.1016/j.canlet.2021.08.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34637843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34637843"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Sreya Tarafdar, Jerrod A Poe, Thomas E Smithgall "}, {"type": "b", "children": [{"type": "t", "text": "The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.572099"}], "href": "https://doi.org/10.1074/jbc.M114.572099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24722985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24722985"}]}]}]}
Synonyms	PSCTK4
Proteins	TEC_HUMAN
NCBI Gene ID	7006
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TEC has 7,025 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 125 datasets.

Click the + buttons to view associations for TEC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TEC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TEC gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TEC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TEC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TEC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TEC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TEC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TEC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TEC gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TEC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TEC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TEC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TEC gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TEC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TEC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TEC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TEC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TEC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TEC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TEC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TEC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TEC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TEC gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TEC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TEC gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TEC gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TEC gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TEC protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TEC gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TEC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TEC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TEC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TEC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TEC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TEC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TEC gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TEC from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TEC gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with TEC gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TEC gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TEC gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.