{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTEKT4P2, corresponding to the human gene previously identified as pp5644 (GenBank Accession No. AF289559), encodes a 124–amino acid protein that appears to act as a negative regulator of cell proliferation. Functional studies reveal that overexpression of this gene in HeLa cells potently inhibits both cell growth and the formation of colonies. In addition, TEKT4P2 has been shown to physically interact with FASP1, a phosphatidylinositol-four-phosphate adaptor protein, via several independent assays—including yeast two-hybrid screening, glutathione S-transferase pull-down, and co-immunoprecipitation. This physical association, further supported by co-localization in the cytoplasm, suggests that TEKT4P2 may modulate intracellular signaling pathways that contribute to its growth-suppressive effects in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao-Xia Ye, Hong Lu, Yao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-005-5907-6"}], "href": "https://doi.org/10.1007/s11010-005-5907-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15881666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15881666"}]}]}]}