TEX10 Gene

Name	testis expressed 10
Description	Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTEX10 has emerged as a multifunctional protein in normal cellular physiology. It is a component of a SENP3‐associated complex with PELP1 and WDR18 that regulates ribosome biogenesis by facilitating the maturation and nucleolar release of the large ribosomal subunit, a process governed by dynamic SUMO conjugation. In embryonic stem cells, TEX10 acts as a key pluripotency factor, being enriched at super‑enhancers in a Sox2‑dependent manner to coordinate histone acetylation and DNA demethylation, thereby maintaining self‑renewal and early embryonic development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, TEX10 functions as an oncogenic driver that promotes stem cell‑like traits, tumor progression, and therapy resistance. In esophageal squamous cell carcinoma, elevated TEX10 expression is linked to enhanced proliferation, epithelial‑mesenchymal transition, and activation of Wnt/β‑catenin signaling. Likewise, in hepatocellular carcinoma, TEX10 sustains cancer stem cell properties and facilitates chemoresistance via STAT3 pathway activation. Furthermore, in urinary bladder carcinoma, high TEX10 levels correlate with increased cell proliferation and metastasis, likely via modulation of XRCC6‑related signaling that also contributes to radiotherapy resistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTEX10 itself is intricately regulated by noncoding RNA networks that further influence tumorigenesis. In pancreatic cancer, a competing endogenous RNA network centered on GATA3‑AS1 and miR‑130b‑15p modulates TEX10 expression, thereby affecting cell growth, invasion, stemness, and Wnt/β‑catenin signaling. Similarly, in liver cancer, the long noncoding RNA RSU1P2 acts by sponging let‑7a to relieve its repression on TEX10, which in turn promotes tumor progression and cancer stem cell‑like properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elisabeth Finkbeiner, Markus Haindl, Stefan Muller "}, {"type": "b", "children": [{"type": "t", "text": "The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.33"}], "href": "https://doi.org/10.1038/emboj.2011.33"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21326211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21326211"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pavlos Fanis, Nynke Gillemans, Ali Aghajanirefah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M112.017194"}], "href": "https://doi.org/10.1074/mcp.M112.017194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22872859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22872859"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junjun Ding, Xin Huang, Ningyi Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2015.04.001"}], "href": "https://doi.org/10.1016/j.stem.2015.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25936917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25936917"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaocong Xiang, Rong Xiong, Chunlei Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7376"}], "href": "https://doi.org/10.3892/or.2019.7376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31638260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31638260"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaocong Xiang, Li Deng, Rong Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2018.1480208"}], "href": "https://doi.org/10.1080/15384101.2018.1480208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30045663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30045663"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sheng Luo, Wenjin Wang, Jingfang Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5975893"}], "href": "https://doi.org/10.1155/2021/5975893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34966825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34966825"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yuhong Liu, Gang Xu, Lin Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA GATA3‑AS1‑miR‑30b‑5p‑Tex10 axis modulates tumorigenesis in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8010"}], "href": "https://doi.org/10.3892/or.2021.8010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33760161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33760161"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jia-Hong Liang, Qiao-Dong Xu, Song-Gang Gu "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2031394"}], "href": "https://doi.org/10.1080/21655979.2022.2031394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35156514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35156514"}]}]}]}
Synonyms	IPI1, BA208F1.2
Proteins	TEX10_HUMAN
NCBI Gene ID	54881
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TEX10 has 7,941 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for TEX10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TEX10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TEX10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TEX10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TEX10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TEX10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TEX10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TEX10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TEX10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TEX10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TEX10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TEX10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TEX10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TEX10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TEX10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TEX10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TEX10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TEX10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TEX10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TEX10 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TEX10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TEX10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TEX10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TEX10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TEX10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TEX10 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TEX10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TEX10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with TEX10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TEX10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DGIdb Drug Targets 2026	interacting drugs for TEX10 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TEX10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TEX10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TEX10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TEX10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TEX10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TEX10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TEX10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TEX10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TEX10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TEX10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TEX10 from the GeneSigDB Published Gene Signatures dataset.