{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe body of the provided abstracts extensively discusses the diverse roles of pulmonary collectins—particularly surfactant proteins A (SP‐A) and D (SP‐D)—in maintaining lung homeostasis and orchestrating innate immune responses. These studies show that SP‐A and SP‐D facilitate the removal of apoptotic cells, enhance microbial clearance, modulate cytokine production, and even influence processes such as parturition and tissue remodeling. In addition, several reports delineate how these collectins bind pathogens or pathogen‐associated molecular patterns, thereby triggering receptor‐mediated phagocytosis and regulating inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther abstracts delve deeper into the regulatory mechanisms by which SP‐A and SP‐D shape pulmonary responses—demonstrating their ability to modulate receptor trafficking, cytokine gene expression, and apoptosis, as well as to influence surfactant lipid uptake and metabolism. These studies document that SP‐A, for example, can inhibit proinflammatory signaling (e.g., TNF‐α and NF‐κB activation), protect against oxidant‐mediated dysfunction, and even interact with specific cellular receptors (such as TLR4 or SP‐R210) to fine‐tune immune cell behavior during infections and injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}, {"type": "fg_fs", "start_ref": "15", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nImportantly, despite the breadth of information on these pulmonary collectins and their multifaceted roles in lung immunity and physiology, none of the provided abstracts address or mention TEX13C. As such, there is no evidence within this collection of studies to define or infer a biological function for TEX13C in the context of pulmonary host defense, inflammation, or surfactant metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "40"}, {"type": "fg_f", "ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R William Vandivier, Carol Anne Ogden, Valerie A Fadok, et al. 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