{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTFG is a multifunctional protein pivotal for maintaining the early secretory pathway. It organizes transitional ER and ER exit sites by concentrating COPII‐coated carriers at the ER–Golgi intermediate compartments. Structural studies indicate that TFG oligomerizes into flexible, octameric cup‐like polymers that locally tether vesicles, thereby promoting efficient cargo export including procollagen, and it also interacts with Ca²⁺‐responsive factors such as ALG‐2 to modulate its retention and polymerization at ER exit sites. Moreover, recent findings implicate TFG in the regulation of autophagosome biogenesis through its influence on ULK1 puncta formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in TFG are now recognized as causative for a spectrum of neurodegenerative and neuropathic disorders—including hereditary motor and sensory neuropathy with proximal predominance (HMSN‐P), hereditary spastic paraplegia (HSP), and certain forms of Charcot–Marie–Tooth disease (CMT). Disease‐linked mutations impair TFG’s oligomerization and disrupt its role in ER export, resulting in cytoplasmic aggregation of TFG and mislocalization of other proteins such as TDP‐43, along with fragmentation of the Golgi apparatus and disturbance of ER organization. These molecular defects contribute to altered neuronal proteostasis, aberrant mitochondrial dynamics, and eventually neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the field of oncogenesis and transcriptional regulation, TFG is also implicated via its involvement in fusion gene events. Chimeric fusions—such as TFG–NOR1 and TFG–TEC—have been detected in extraskeletal myxoid chondrosarcomas and thyroid cancers, respectively, leading to aberrant transcriptional activation. In addition, TFG appears to contribute to oncogenic processes by modulating signaling pathways including NF‑κB, through associations with regulatory proteins like SHP‑1, and by engaging in novel fusion events that may have gain‐of‐function roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTFG further modulates immune responses. It has been shown to bind to TRIM68, and in doing so, it negatively regulates RIG‑I–mediated type I interferon production. This function positions TFG as an important negative regulator in innate antiviral signaling, ensuring that interferon responses remain appropriately calibrated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vesicular trafficking and signaling, TFG is important for maintaining cellular protein homeostasis. Overexpression studies reveal that TFG can act as an inhibitory regulator of the ubiquitin–proteasome system (UPS), leading to increased ubiquitination of ER‐resident proteins and induction of ER stress. In parallel, recent reports highlight a role for TFG in the early DNA damage response by preserving the stability of FANCD2‐V2 and in regulating mitochondrial integrity, thereby linking disruptions in TFG function to metabolic impairment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinical studies underscore the genetic and phenotypic heterogeneity associated with TFG mutations. Domain‐specific alterations affect TFG oligomerization and complex formation, correlating with a spectrum of inherited neuropathies—from predominantly motor and sensory forms (HMSN‐P and CMT) to spastic paraplegias with additional features such as optic atrophy. Such genotype–phenotype correlations implicate defective ER morphology, impaired protein export, and even mitochondrial fragmentation in the pathogenesis of these disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}, {"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging roles of TFG in other cellular contexts are also being recognized. In sebocytes, TFG promotes lipid synthesis by upregulating key lipogenic regulators, linking intracellular trafficking processes to metabolic outputs. Furthermore, rare TFG–MET rearrangements in congenital mesenchymal tumors point toward a broader involvement of TFG in modulating oncogenic kinase signaling and cellular differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adam Johnson, Nilakshee Bhattacharya, Michael Hanna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201489032"}], "href": "https://doi.org/10.15252/embj.201489032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25586378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25586378"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Janine McCaughey, Victoria J Miller, Nicola L Stevenson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.04.062"}], "href": "https://doi.org/10.1016/j.celrep.2016.04.062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27184855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27184855"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takashi Kanadome, Hideki Shibata, Keiko Kuwata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.13949"}], "href": "https://doi.org/10.1111/febs.13949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27813252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27813252"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "So-Ra Choi, Yul-Lye Hwang, Soo Jung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tropomyosin-receptor kinase fused gene (TFG) regulates lipid production in human sebocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-43209-3"}], "href": "https://doi.org/10.1038/s41598-019-43209-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31036933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31036933"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marianna Carinci, Beatrice Testa, Matteo Bordi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG binds LC3C to regulate ULK1 localization and autophagosome formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2019103563"}], "href": "https://doi.org/10.15252/embj.2019103563"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33932238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33932238"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hiroyuki Ishiura, Wataru Sako, Mari Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2012.07.014"}], "href": "https://doi.org/10.1016/j.ajhg.2012.07.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22883144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22883144"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Christian Beetz, Adam Johnson, Amber L Schuh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1217197110"}], "href": "https://doi.org/10.1073/pnas.1217197110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23479643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23479643"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pei-Chien Tsai, Yen-Hua Huang, Yuh-Cherng Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000000758"}], "href": "https://doi.org/10.1212/WNL.0000000000000758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25098539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25098539"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Afagh Alavi, Hosein Shamshiri, Shahriar Nafissi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HMSN-P caused by p.Pro285Leu mutation in TFG is not confined to patients with Far East ancestry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2014.11.021"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2014.11.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25725944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25725944"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Liena E O Elsayed, Inaam N Mohammed, Ahlam A A Hamed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hereditary spastic paraplegias: identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2016.108"}], "href": "https://doi.org/10.1038/ejhg.2016.108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27601211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27601211"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Erin L Slosarek, Amber L Schuh, Iryna Pustova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.07.081"}], "href": "https://doi.org/10.1016/j.celrep.2018.07.081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30157421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30157421"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marzieh Khani, Hanieh Taheri, Hosein Shamshiri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Continuum of phenotypes in hereditary motor and sensory neuropathy with proximal predominance and Charcot-Marie-Tooth patients with TFG mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61184"}], "href": "https://doi.org/10.1002/ajmg.a.61184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31111683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31111683"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ling Xu, Yaru Wang, Wenqing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TFG"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " mutation causes autosomal-dominant spastic paraplegia and defects in autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg-2023-109485"}], "href": "https://doi.org/10.1136/jmg-2023-109485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37890998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37890998"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Cheng-Tsung Hsiao, Tzu-Yun Tsai, Ting-Yi Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a novel TFG variant causing autosomal recessive pure hereditary spastic paraplegia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Transl Neurol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/acn3.52113"}], "href": "https://doi.org/10.1002/acn3.52113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38837630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38837630"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Masanori Hisaoka, Tsuyoshi Ishida, Tetsuo Imamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20044"}], "href": "https://doi.org/10.1002/gcc.20044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15188455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15188455"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Claudia Miranda, Emanuela Roccato, Giovanna Raho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.20644"}], "href": "https://doi.org/10.1002/jcp.20644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16547966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16547966"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Andrew Chase, Thomas Ernst, Andreas Fiebig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2009.011536"}], "href": "https://doi.org/10.3324/haematol.2009.011536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19797732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19797732"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Li Shijie, Pan Zhen, Qin Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ctm2.377"}], "href": "https://doi.org/10.1002/ctm2.377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34185412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34185412"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Takuya Miyabayashi, Tatsuhiro Ochiai, Naoki Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel homozygous mutation of the TFG gene in a patient with early onset spastic paraplegia and later onset sensorimotor polyneuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-018-0538-4"}], "href": "https://doi.org/10.1038/s10038-018-0538-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30467354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30467354"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Dallah Yoo, Wonjae Lee, Seung-Jae Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel TFG Mutation in a Korean Family with α-Synucleinopathy and Amyotrophic Lateral Sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mov Disord (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mds.28857"}], "href": "https://doi.org/10.1002/mds.28857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34779525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34779525"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Na-Rae Lee, Han-Bo Shin, Hye-In Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused gene (TFG) protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.06.061"}], "href": "https://doi.org/10.1016/j.bbrc.2013.06.061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23810392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23810392"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Takuya Yagi, Daisuke Ito, Norihiro Suzuki "}, {"type": "b", "children": [{"type": "t", "text": "Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin-proteasome system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2014.02.011"}], "href": "https://doi.org/10.1016/j.nbd.2014.02.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24613659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24613659"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "A Catania, R Battini, T Pippucci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "R106C TFG variant causes infantile neuroaxonal dystrophy \"plus\" syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-018-0552-x"}], "href": "https://doi.org/10.1007/s10048-018-0552-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29971521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29971521"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Chi Ma, Kanani Hokutan, Yihang Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103782"}], "href": "https://doi.org/10.18632/aging.103782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33099537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33099537"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Mehdi Khorrami, Mohammad Amin Tabatabaiefar, Erfan Khorram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homozygous TFG gene variants expanding the mutational and clinical spectrum of hereditary spastic paraplegia 57 and a review of literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-021-00919-9"}], "href": "https://doi.org/10.1038/s10038-021-00919-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33767317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33767317"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Xihui Chen, Fangfang Liu, Kun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "CNS Neurosci Ther (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cns.13943"}], "href": "https://doi.org/10.1111/cns.13943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35986567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35986567"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Michael Michal, Nasir Ud Din, Marián Švajdler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFG::MET-rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low-grade triphasic morphology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.23111"}], "href": "https://doi.org/10.1002/gcc.23111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36464850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36464850"}]}]}]}