Name | thrombospondin 4 |
Description | The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTHBS4 plays an important role in the nervous system where it is expressed by neurons and accumulates in synapse‐rich regions such as the neuromuscular junction. Functional studies have shown that THBS4 promotes neurite outgrowth and appears to enhance presynaptic excitatory input—features that may contribute to neuropathic pain states as well as to the unique synaptic organization and cognitive capabilities observed in the human brain."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its neural functions, THBS4 serves as a critical extracellular matrix scaffold that influences musculoskeletal development. Distinctive Ca²⁺‐binding properties govern its structural interactions and stability, and experimental models demonstrate that THBS4 is essential for proper muscle attachment and ECM assembly at myotendinous junctions. Its interactions with other matrix components support collagen fibrillogenesis, modulate cartilage remodeling (as seen in osteoarthritis) and contribute to bone formation during endochondral ossification, while altered THBS4 expression has also been implicated in tendinopathy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant expression and dysregulation of THBS4 are emerging as common features in various human cancers. Studies have documented its overexpression in diffuse‐type gastric adenocarcinomas, as well as in colorectal, breast, prostate, hepatocellular, and bladder cancers. In these diverse tumor settings, THBS4 appears to promote disease progression by enhancing cell migration, invasion, and epithelial–mesenchymal transition, in part through interactions with integrins and activation of signaling cascades such as FAK/PI3K/AKT and MAPK. In some cancers, noncoding RNAs modulate THBS4 levels and its downstream oncogenic effects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond development and cancer, THBS4 has been implicated in cardiovascular and inflammatory processes. A number of genetic and clinical studies suggest that variants in the THBS4 locus may modulate susceptibility to coronary heart disease, myocardial infarction, and peripheral arterial disease. Although the mechanistic underpinnings remain to be fully elucidated, THBS4 is thought to influence vascular inflammation, endothelial signaling and angiogenic responses that contribute to these disease states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTHBS4 also contributes to tissue repair and remodeling. In cutaneous models, THBS4 is a downstream effector of TGF‐β signaling that fosters hypertrophic scar formation and enhances keratinocyte migration, thereby accelerating wound closure. These activities underscore the protein’s multifaceted role in regenerative responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, a distinct C‐terminal fragment of THBS4 has been shown to stimulate erythroid cell proliferation, suggesting that THBS4 may also participate in hematopoietic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S Arber, P Caroni "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (1995)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.131.4.1083"}], "href": "https://doi.org/10.1083/jcb.131.4.1083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "7490284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/7490284"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mario Cáceres, Carolyn Suwyn, Marcelia Maddox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased cortical expression of two synaptogenic thrombospondins in human brain evolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cereb Cortex (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cercor/bhl140"}], "href": "https://doi.org/10.1093/cercor/bhl140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17182969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17182969"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Doo-Sik Kim, Kang-Wu Li, Amin Boroujerdi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.6494-11.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.6494-11.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22745497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22745497"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Olga Stenina-Adognravi, Edward F Plow "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 in tissue remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2017.11.006"}], "href": "https://doi.org/10.1016/j.matbio.2017.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29138119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29138119"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tina M Misenheimer, Deane F Mosher "}, {"type": "b", "children": [{"type": "t", "text": "Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M504696200"}], "href": "https://doi.org/10.1074/jbc.M504696200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16246837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16246837"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Arul Subramanian, Thomas F Schilling "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.02372"}], "href": "https://doi.org/10.7554/eLife.02372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24941943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24941943"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Heng'an Ge, Amrit Shrestha, Centao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 148a-3p promotes Thrombospondin-4 expression and enhances angiogenesis during tendinopathy development by inhibiting Krüppel-like factor 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.05.167"}], "href": "https://doi.org/10.1016/j.bbrc.2018.05.167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29807011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29807011"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jan M Gebauer, Anna Köhler, Helen Dietmar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-35447-8"}], "href": "https://doi.org/10.1038/s41598-018-35447-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30464261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30464261"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kathrin Maly, Inna Schaible, Jana Riegger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20020447"}], "href": "https://doi.org/10.3390/ijms20020447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30669608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30669608"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "E Andrés Sastre, K Maly, M Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2021.115999"}], "href": "https://doi.org/10.1016/j.bone.2021.115999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33971315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33971315"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Remco van Doorn, Willem H Zoutman, Remco Dijkman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2005.11.353"}], "href": "https://doi.org/10.1200/JCO.2005.11.353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15897551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15897551"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sonia A Greco, June Chia, Kelly J Inglis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-10-494"}], "href": "https://doi.org/10.1186/1471-2407-10-494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20846368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20846368"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Susann Förster, Stephan Gretschel, Thomas Jöns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2011.99"}], "href": "https://doi.org/10.1038/modpathol.2011.99"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21701537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21701537"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Amy E McCart Reed, Sarah Song, Jamie R Kutasovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virchows Arch (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00428-013-1468-3"}], "href": "https://doi.org/10.1007/s00428-013-1468-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23942617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23942617"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiandong Lin, Don Hu, Gang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations of THBS2 and THBS4 polymorphisms to gastric cancer in a Southeast Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergen.2016.04.003"}], "href": "https://doi.org/10.1016/j.cancergen.2016.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27160021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27160021"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jinliang Liu, Gong Cheng, Haiwei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal regulation of long noncoding RNAs THBS4‑003 and THBS4 control migration and invasion in prostate cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.5443"}], "href": "https://doi.org/10.3892/mmr.2016.5443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27357608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27357608"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Fang Su, Jun Zhao, Shukui Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of Thrombospondin 4 correlates with loss of miR-142 and contributes to migration and vascular invasion of advanced hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15054"}], "href": "https://doi.org/10.18632/oncotarget.15054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28177895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28177895"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiangbo Chen, Yisen Huang, Yubin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THBS4 predicts poor outcomes and promotes proliferation and metastasis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13105-019-00665-9"}], "href": "https://doi.org/10.1007/s13105-019-00665-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30746617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30746617"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hongfen Wu, Guangcong Zhang, Zhi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 expression as a prognostic marker in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.02.049"}], "href": "https://doi.org/10.1016/j.gene.2019.02.049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30802535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30802535"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kenji Kuroda, Masakazu Yashiro, Tomohiro Sera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0224727"}], "href": "https://doi.org/10.1371/journal.pone.0224727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31703077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31703077"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yi Hou, Hai Li, Wei Huo "}, {"type": "b", "children": [{"type": "t", "text": "THBS4 silencing regulates the cancer stem cell-like properties in prostate cancer via blocking the PI3K/Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.23989"}], "href": "https://doi.org/10.1002/pros.23989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32421868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32421868"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Dan Guo, Dan Zhang, Mudan Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THBS4 promotes HCC progression by regulating ITGB1 via FAK/PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202000043R"}], "href": "https://doi.org/10.1096/fj.202000043R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32567740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32567740"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Junki Harada, Yasuyoshi Miyata, Kyohei Araki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vivo (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/invivo.12429"}], "href": "https://doi.org/10.21873/invivo.12429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33910854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33910854"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "LingNan He, WeiJun Wang, HuiYing Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Helicobacter pylori"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203334"}], "href": "https://doi.org/10.18632/aging.203334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34390328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34390328"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "S Matthijs Boekholdt, Mieke D Trip, Ron J G Peters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.atv.0000046235.22451.66"}], "href": "https://doi.org/10.1161/01.atv.0000046235.22451.66"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12482844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12482844"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Xiaoyang Zhou, Jianfeng Huang, Jianhong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Sci (Lond) (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CS20030322"}], "href": "https://doi.org/10.1042/CS20030322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14674882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14674882"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "J J McCarthy, A Parker, R Salem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2003.016584"}], "href": "https://doi.org/10.1136/jmg.2003.016584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15121769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15121769"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jennifer Wessel, Eric J Topol, Ming Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am Heart J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ahj.2003.12.013"}], "href": "https://doi.org/10.1016/j.ahj.2003.12.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15131549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15131549"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jianxun Cui, Edward Randell, James Renouf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am Heart J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ahj.2006.06.002"}], "href": "https://doi.org/10.1016/j.ahj.2006.06.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16923428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16923428"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Byung Lae Park, Yoon Jun Kim, Hyun Sub Cheong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emm.2006.82"}], "href": "https://doi.org/10.1038/emm.2006.82"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17202846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17202846"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Wendy W J van de Sande, Ahmed Fahal, Henri Verbrugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.179.5.3065"}], "href": "https://doi.org/10.4049/jimmunol.179.5.3065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17709521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17709521"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "James P Corsetti, Dan Ryan, Arthur J Moss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1160/TH11-03-0206"}], "href": "https://doi.org/10.1160/TH11-03-0206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22011848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22011848"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xiao-Jie Zhang, Chun-Yan Wei, Wen-Bo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between single nucleotide polymorphisms in thrombospondins genes and coronary artery disease: A meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.thromres.2015.04.019"}], "href": "https://doi.org/10.1016/j.thromres.2015.04.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25976449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25976449"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Noura A Abdelmonem, Nancy O Turky, Ingy M Hashad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Thrombospondin-1 (N700S) and Thrombospondin-4 (A387P) Gene Polymorphisms with the Incidence of Acute Myocardial Infarction in Egyptians"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Pharm Biotechnol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1389201019666180115144028"}], "href": "https://doi.org/10.2174/1389201019666180115144028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29336258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29336258"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Bernhard Zierfuss, Clemens Höbaus, Carsten T Herz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Heart Vessels (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00380-019-01453-7"}], "href": "https://doi.org/10.1007/s00380-019-01453-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31227875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31227875"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Wei Qian, Ning Li, Qian Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombospondin-4 critically controls transforming growth factor β1 induced hypertrophic scar formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26877"}], "href": "https://doi.org/10.1002/jcp.26877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30132849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30132849"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Kristina Mäemets-Allas, Mariliis Klaas, Claudia Griselda Cárdenas-León, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.12.052"}], "href": "https://doi.org/10.1016/j.bbrc.2022.12.052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36566568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36566568"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Luis F Congote, Marcos R Difalco, Bernard F Gibbs "}, {"type": "b", "children": [{"type": "t", "text": "The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.09.107"}], "href": "https://doi.org/10.1016/j.bbrc.2004.09.107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15474480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15474480"}]}]}]}
|
Synonyms | TSP4, TSP-4 |
Proteins | TSP4_HUMAN |
NCBI Gene ID | 7060 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
THBS4 has 6,489 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.
Click the + buttons to view associations for THBS4 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of THBS4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of THBS4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of THBS4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of THBS4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of THBS4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of THBS4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of THBS4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of THBS4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of THBS4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of THBS4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with THBS4 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of THBS4 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of THBS4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of THBS4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of THBS4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing THBS4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing THBS4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with THBS4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with THBS4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of THBS4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with THBS4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with THBS4 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with THBS4 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by THBS4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with THBS4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with THBS4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with THBS4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with THBS4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with THBS4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at THBS4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of THBS4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of THBS4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing THBS4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with THBS4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with THBS4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of THBS4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with THBS4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing THBS4 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of THBS4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of THBS4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of THBS4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of THBS4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of THBS4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of THBS4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding THBS4 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving THBS4 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving THBS4 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving THBS4 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing THBS4 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing THBS4 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing THBS4 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by THBS4 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by THBS4 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by THBS4 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of THBS4 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of THBS4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of THBS4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of THBS4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of THBS4 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
GWASdb SNP-Disease Associations | diseases associated with THBS4 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with THBS4 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of THBS4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of THBS4 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of THBS4 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of THBS4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of THBS4 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HuBMAP Azimuth Cell Type Annotations | cell types associated with THBS4 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with THBS4 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for THBS4 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of THBS4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving THBS4 protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of THBS4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of THBS4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with THBS4 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of THBS4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of THBS4 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of THBS4 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of THBS4 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing THBS4 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain THBS4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by THBS4 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of THBS4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by THBS4 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of THBS4 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of THBS4 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of THBS4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of THBS4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving THBS4 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving THBS4 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2014 | pathways involving THBS4 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving THBS4 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of THBS4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of THBS4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at THBS4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of THBS4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of THBS4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of THBS4 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of THBS4 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of THBS4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of THBS4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of THBS4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of THBS4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of THBS4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of THBS4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with THBS4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with THBS4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving THBS4 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving THBS4 protein from the WikiPathways Pathways 2024 dataset. | |